Method and apparatus for calibration of gas and liquid concentration sensors without the need for known calibration standards
A device and method for calibrating a NO delivery device using NO and NO 2 measurements, without using a known standard.
1 . A system comprising:
a device configured to deliver a gas flow comprising a predetermined amount of NO to a patient,
an NO sensor configured to measure the predetermined amount of NO;
a compartment having a volume of 0.5 to 1 liter that is in fluid communication with the device and configured to receive a portion of the gas flow from the device; and wherein the compartment comprises an oxygen-containing gas;
a sampling module that receives the portion of the gas flow from the compartment over a predetermined time and is configured to measure an amount of NO in the portion of the gas flow;
an analyzing module configured to determine the amount of NO in the portion of the gas and compare it to the predetermined amount of NO; and
a control module configured to adjust the NO sensor if the determined amount of NO is different from the predetermined amount of NO, wherein when the determined amount of NO is 20% greater than or 20% lower than the predetermined amount of NO, the control module adjusts the NO sensor.
2 . The system of claim 1 , wherein the sampling module comprises at least one NO 2 sensor and/or at least one O 2 sensor.
3 . The system of claim 2 , wherein when a sum of the NO and NO 2 sensor normalized output is not constant, the control module indicates failure in the NO and/or NO 2 sensor.
4 . The system of claim 1 , wherein the amount of NO in the compartment reacts with oxygen-containing gas to form NO 2 .
5 . The system of claim 4 , wherein the analyzing module measures a decrease in NO concentration and/or increase in NO 2 concentration.
6 . The system of claim 5 , wherein a slope of the decrease in NO concentration is substantially equal to a slope of the increase in NO 2 concentration.
7 . A method comprising:
providing a gas flow comprising a predetermined amount of NO;
diverting a portion of the gas flow to a compartment having a volume of 0.5 to 1 liter and comprising a predetermined amount of an oxygen-containing gas;
continuously sampling the portion of the gas flow from the compartment over a predetermine time to analyze an amount of NO in the portion of the gas with an NO sensor;
comparing the amount of NO with the predetermined amount of NO; and
adjusting the NO sensor if the predetermined amount of NO is 20% greater than or 20% lower than the amount of NO.
8 . The method of claim 7 , further comprising a step of analyzing an amount of NO 2 with a NO 2 sensor, wherein NO 2 is formed by reacting NO with the oxygen-containing gas.
9 . The method of claim 8 , further comprising varying the predetermined amount of the oxygen-containing gas and analyzing the amount of NO 2 as a function of the varied predetermined amount of oxygen-containing gas.
10 . The method of claim 8 , wherein a linear regression (r) of a slope of an increase in NO 2 concentration and/or a decrease in NO concentration is less than <99, the method comprises determining that the NO sensor and/or NO 2 sensors are damaged.
11 . The method of claim 8 , wherein when a sum of the NO and NO 2 sensor normalized output is not constant, the control module indicates failure in the NO and/or NO 2 sensor.
12 . The method of claim 7 , further comprising varying the predetermined amount of the oxygen-containing gas and analyzing the amount of NO as a function of the varied predetermined amount of oxygen-containing gas.