Granted Patent B2

US 12,564,440 · App. 18/353,867 · Granted Mar 3, 2026

Inventors: Roman Turovskiy (San Francisco, CA); David R. Kirkland (Hayward, CA); David J. Danitz (San Jose, CA); David Moosavi (Hayward, CA); Rodel Quintos (Cupertino, CA); Ryan C. Bradway (Murrieta, CA); Andy E. Denison (Temecula, CA); Dylan R. Montgomery (Murrieta, CA); Peter J. D'Aquanni (Murrieta, CA)

Assignee: Pulse Biosciences, Inc.

A61B18/1492A61B2017/00154A61B2018/00267A61B2018/00577A61B2018/00839A61B2018/1467

Abstract

Claims (41)

1 . An apparatus for delivering pulsed electric fields, the apparatus comprising:

an elongate body;

a plurality of arms configured to extend from the elongate body at an angle in a deployed state;

a first electrode extending between and connected to the plurality of arms and forming a first treatment electrode;

a second electrode extending between and connected to the plurality of arms and forming a second treatment electrode that is radially outward of the first treatment electrode in the deployed state; and

one or more mapping and/or sensing electrodes on the plurality of arms.

2 . The apparatus of claim 1 , wherein the one or more mapping and/or sensing electrodes comprises mapping and/or sensing electrodes on an extension region of each arm of the plurality of arms that is radially outward from the second treatment electrode in the deployed state.

3 . The apparatus of claim 2 , wherein the one or more mapping and/or sensing electrodes comprises one or more mapping and/or sensing electrodes on an intermediate region of each arm of the plurality of arms that is between the first treatment electrode and the second treatment electrode.

4 . The apparatus of claim 1 , wherein the arms of the plurality of arms are configured to extend from the elongate body in the deployed state at an angle of between 20 and 90 degrees relative to the elongate body.

5 . The apparatus of claim 1 , wherein the arms of the plurality of arms are configured to transition from a delivery state, wherein each arm of the plurality of arms at least partially within the elongate body or within a delivery sheath, into a deployed state wherein each arm of the plurality of arms extends at an angle from the elongate body.

6 . The apparatus of claim 1 , further comprising a spacer in a distal end region of the elongate body to maintain a spacing of each arm of the plurality of arms within the distal end region of the elongate body.

7 . The apparatus of claim 1 , wherein the first electrode comprises a first plurality of lengths of wire forming arcs extending between the plurality of arms; further wherein the second electrode comprises a second plurality of lengths of wire forming arcs extending between the plurality of arms.

8 . The apparatus of claim 1 , wherein the first electrode comprises a first loop forming the first treatment electrode and the second electrode comprises a second loop forming the second treatment electrode.

9 . The apparatus of claim 1 , further comprising a central electrode configured to extend distally from a distal end of the elongate body.

10 . The apparatus of claim 9 , wherein the central electrode comprises 1) a mapping and/or sensing electrode, and/or 2) a central treatment electrode configured to operate at a different polarity than at least one of the first or second treatment electrodes.

11 . The apparatus of claim 1 , further comprising an electromagnetic sensor coupled to one or more arms of the plurality of arms.

12 . The apparatus of claim 1 , further comprising a third electrode extending between and connected to the plurality of arms and forming a third treatment electrode that is radially outward of the first treatment electrode and the second treatment electrode in the deployed state.

13 . The apparatus of claim 1 , wherein the first electrode and the second electrode are each formed of a wire having a diameter of less than 0.2 mm.

14 . The apparatus of claim 1 , wherein the first treatment electrode comprises an anode and the second treatment electrode comprises a cathode, wherein the apparatus is configured to deliver a pulse energy between the first treatment electrode and the second treatment electrode.

15 . The apparatus of claim 1 , wherein the first and the second treatment electrodes are configured to deliver microsecond, nanosecond or picosecond electric pulses.

16 . The apparatus of claim 1 , wherein the first treatment electrode and the second treatment electrode have a different size circumference.

17 . The apparatus of claim 1 , wherein at least some arms of the plurality of arms comprise hollow insulated members within or through which at least a portion of the first treatment electrode or the second treatment electrode and/or electrical connectors extend.

18 . The apparatus of claim 1 , wherein at least one electrode is configured as both a treatment electrode and as a mapping/sensing electrode.

19 . An apparatus for delivering pulsed electric fields, the apparatus comprising:

an elongate body;

a first plurality of arms configured to extend from the elongate body at an angle in a deployed state;

a second plurality of arms configured to extend from the elongate body at an angle in the deployed state;

a first electrode extending between and connected to the first plurality of arms and forming a first treatment electrode;

a second electrode extending between and connected to the second plurality of arms and forming a second treatment electrode that is separated from the first treatment electrode along a longitudinal axis of the elongate body; and

one or more mapping and/or sensing electrodes.

20 . The apparatus of claim 19 , further comprising a plurality of struts extending between the first treatment electrode and the second treatment electrode substantially parallel to a distal end region of the elongate body, wherein the second treatment electrode is axially separated from the first treatment electrode by the plurality of struts.

21 . The apparatus of claim 20 , wherein at least one of the one or more mapping and/or sensing electrodes is on the struts of the plurality of struts.

22 . The apparatus of claim 20 , wherein the struts of the plurality of struts are coupled to at least one of the first plurality of arms and/or the second plurality of arms.

23 . The apparatus of claim 20 , wherein the substantially parallel to the distal end region of the elongate body comprises up to plus/minus 10 degrees from the longitudinal axis of the distal end region of the elongate body.

24 . The apparatus of claim 19 , wherein the one or more mapping and/or sensing electrodes comprises a plurality of mapping and/or sensing electrodes and at least some of the plurality of mapping and/or sensing electrodes are on the first plurality of arms.

25 . The apparatus of claim 19 , wherein the first plurality of arms is rotationally offset from the second plurality of arms.

26 . The apparatus of claim 19 , wherein the arms of the first plurality of arms and/or the second plurality of arms are configured to extend from the elongate body in the deployed state at an angle of between 20 and 90 degrees relative to the elongate body.

27 . The apparatus of claim 19 , wherein the arms of the first and second plurality of arms are configured to transition from a delivery state wherein each arm of the first and second plurality of arms at least partially within a delivery sheath or within the elongate body into a deployed state wherein each arm of the first and second plurality of arms extends at an angle from the elongate body.

28 . The apparatus of claim 19 , further comprising a central electrode configured to extend distally from a distal end of the elongate body, wherein the central electrode comprises a mapping and/or sensing electrode.

29 . The apparatus of claim 19 , further comprising a central electrode configured to extend distally from a distal end of the elongate body, wherein the central electrode comprises a treatment electrode and wherein the apparatus further configured to apply bipolar energy between either: 1) the center electrode and the first treatment electrode, 2) the center electrode and the second treatment electrode, or 3) the first treatment electrode and the second treatment electrode.

30 . The apparatus of claim 19 , wherein the one or more mapping and/or sensing electrodes is also configured for use as a treatment electrode.

Assignments (2)

Continuity (5)

References Cited (226)