Methods of increasing magnesium bioavailability and absorption
The present disclosure relates to compositions and methods of increasing magnesium bioavailability and absorption.
1 . A method for increasing magnesium absorption in a livestock animal in need thereof, the method comprising identifying a livestock animal in need of increased magnesium absorption; and
administering a magnesium salt and an ascorbate source to the livestock animal, wherein the molar ratio of the ascorbate source to the magnesium salt is from about 1:1 to about 2:1, and
wherein the absorption of magnesium is increased in the livestock animal as compared to administration of the magnesium salt alone.
2 . The method of claim 1 , wherein the ascorbate source comprises ascorbic acid.
3 . The method of claim 1 , wherein the ascorbate source comprises an ascorbate salt.
4 . The method of claim 1 , wherein the ascorbate source comprises magnesium ascorbate.
5 . The method of claim 1 , wherein the magnesium salt and the ascorbate source are formulated into a single composition.
6 . The method of claim 1 , wherein the magnesium salt and the ascorbate source are administered separately, but within 15 min of each other.
7 . The method of claim 1 , wherein absorption is via the livestock animal's GI tract.
8 . The method of claim 1 , wherein the magnesium salt and the ascorbate source are administered orally.
9 . The method of claim 1 , wherein the molar ratio of the ascorbate source to the magnesium salt is about 1:1.
10 . The method of claim 1 , wherein the absorption of magnesium is increased by at least 55% as compared to administration of the magnesium salt alone.
11 . The method of claim 1 , wherein side effects of magnesium supplementation are reduced as compared to administration of the magnesium salt alone.
12 . A method of treating magnesium deficiency in a livestock animal in need thereof, the method comprising
identifying a livestock animal having a magnesium deficiency; and
administering a pharmaceutical composition comprising magnesium salt and an ascorbate source to the livestock animal,
wherein the molar ratio of the ascorbate source to the magnesium salt in the pharmaceutical composition is from about 1:1 to about 2:1.
13 . The method of claim 12 , wherein the absorption is increased at least 55% as compared to administration of the magnesium salt alone.
14 . The method of claim 12 , wherein the pharmaceutical composition is administered orally.
15 . The method of claim 12 , wherein the pharmaceutical composition is a solid dosage form that is a tablet, a capsule, a powder, or a granule.
16 . The method of claim 12 , wherein the pharmaceutical composition is a liquid.