CONTACT LENS TREATING SOLUTION
A contact lens treating solution includes (a) one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof; and (b) one or more antimicrobial agents comprising one or more polyquaternium polymers.
1 . A contact lens treating solution comprising:
(a) one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof; and
(b) one or more antimicrobial agents comprising one or more polyquaternium polymers.
2 . The contact lens treating solution according to claim 1 , comprising:
(a) about 0.05 to about 2.0 wt. % of the one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof, based on the total weight of the contact lens treating solution; and
(b) about 0.00001 to about 0.0010 wt. % of the one or more antimicrobial agents comprising one or more polyquaternium polymers, based on the total weight of the contact lens treating solution.
3 . The contact lens treating solution according to claim 1 , wherein the one or more polyquaternium polymers comprise from about 30 to about 50,000 quaternary-amine-functional repeating units.
4 . The contact lens treating solution according to claim 1 , wherein the one or more polyquaternium polymers have a weight average molecular weight Mw of about 3,000 to about 5,000,000.
5 . The contact lens treating solution according to claim 1 , wherein the one or more polyquaternium polymers are cationic.
6 . The contact lens treating solution according to claim 1 , wherein the one or more polyquaternium polymers comprise Polyquaternium-1.
7 . The contact lens treating solution according to claim 1 , further comprising one or more surfactants.
8 . The contact lens treating solution according to claim 7 , wherein the one or more surfactants are selected from the group consisting of a poloxamer, a poloxamine and mixtures thereof.
9 . The contact lens treating solution according to claim 8 , wherein the poloxamer is present in the contact lens treating solution in an amount ranging from about 0.001 to about 5.0 wt. %, based on the total weight of the contact lens treating solution, and the poloxamine is present in the contact lens treating solution in an amount ranging from about 0.001 to about 5.0 wt. %, based on the total weight of the contact lens treating solution.
10 . The contact lens treating solution according to claim 1 , further comprising one or more additional antimicrobial agents.
11 . The contact lens treating solution according to claim 10 , wherein the one or more additional antimicrobial agents are selected from the group consisting of a polymeric biguanide or a salt or a free base thereof, a terpene compound, a branched, glycerol monoalkyl ether, a branched, glycerol monoalkyl amine, a branched, glycerol monoalkyl sulphide, a fatty acid monoester, wherein the fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion, an amidoamine compound, and combinations thereof.
12 . The contact lens treating solution according to claim 1 , further comprising one or more comfort agents.
13 . The contact lens treating solution according to claim 12 , wherein the one or more comfort agents are selected from the group consisting of a polyol, an antioxidant and a complex carbohydrate.
14 . contact lens treating solution according to claim 13 , wherein the polyol is one or more of glycerol and erythritol.
15 . The contact lens treating solution according to claim 1 , further comprising one or more polysaccharides.
16 . The contact lens treating solution according to claim 14 , wherein the one or more polysaccharides comprise one or more of hyaluronic acid or a salt thereof, chondroitin sulfate, chitosan, aloe vera, carboxymethylcellulose, hemicellulose, hydroxypropyl methyl cellulose, methylcellulose, and ethylcellulose.
17 . The contact lens treating solution according to claim 1 , further comprising a phosphate buffer.
18 . The contact lens treating solution according to claim 1 , in the form of an eye care or a contact lens care product selected from the group consisting of eye drops, a preserved contact lens solution, a contact lens cleaning solution, and a contact lens multi-purpose solution.
19 . A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in a contact lens treating solution for a time period sufficient to clean and disinfect the contact lens, the contact lens treating solution comprising (a) one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof; and (b) one or more antimicrobial agents comprising one or more polyquaternium polymers.
20 . A method for inhibiting adhesion of bacteria to a surface of a contact lens, the method comprising contacting the surface of the contact lens with a contact lens treating solution comprising (a) one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof; and (b) one or more antimicrobial agents comprising one or more polyquaternium polymers.