HYDROGEL IMPLANTS FOR LOWERING INTRAOCULAR PRESSURE
Provided herein are sustained release biodegradable ocular hydrogel implants which are useful for lowering ocular pressure and for treating related conditions.
1 . A sustained release biodegradable intracameral hydrogel implant comprising travoprost and a polymer network.
2 . The hydrogel implant of claim 1 , wherein the polymer network comprises a plurality of polyethylene glycol (PEG) units.
3 - 24 . (canceled)
25 . A method of treating ocular hypertension in a subject in need thereof comprising administering the hydrogel implant of any one of claims 1 to 2 to the eye of a subject.
26 . A method of treating glaucoma in a subject in need thereof comprising administering the hydrogel implant of any one of claims 1 to 2 to the eye of a subject.
27 . The method of claim 26 , wherein the glaucoma is open angle glaucoma.
28 . The method of claim 27 , wherein essentially no endothelial damage occurs following administration of a disclosed implant.