4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid as an antimicrobial compound

1. An 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound having the formula I:

2. A pharmaceutically acceptable composition comprising a therapeutically effective amount of the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 1 and a pharmaceutically acceptable carrier.

3. A method of treating a microbial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 1 .

4. The method of treating the microbial infection of claim 3 , wherein the microbial infection is caused by one or more bacteria or fungi.

5. The method of treating the microbial infection of claim 4 , wherein the microbial infection is caused by one or more gram positive bacteria, one or more gram negative bacteria, one or more fungi, or a combination thereof.

6. The method of treating the microbial infection of claim 5 , wherein the one or more gram positive bacteria are Bacillus cereus, Staphylococcus aureus , or a combination thereof.

7. The method of treating the microbial infection of claim 5 , wherein the one or more gram negative bacteria are Pseudomonas aeruginosa, Escherichia coli , or a combination thereof.

8. The method of treating the microbial infection of claim 5 , wherein the one or more fungi are Aspergillus flavus, Chrysosporium keratinophilum , or a combination thereof.

9. A method of making the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 1 , the method comprising:

mixing 1,2-bis(4-chlorophenyl)ethane-1,2-dione, 4-chlorobenzaldehyde, 4-aminobenzoic acid, and ammonium acetate in pyridinium ionic liquid to obtain a solution;

irradiating the solution followed by cooling to room temperature to obtain a formed precipitate;

purifying the formed precipitate by filtering and recrystallization using ethanol; and

obtaining the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound.

10. The method of making the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 9 , wherein the irradiating step takes place in a sonicator for about 21 minutes.

11. The method of making the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 9 , wherein the irradiating step is conducted at about 50° C.

12. The method of making 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 9 , wherein the purifying step comprises collecting the formed precipitate by filtration and washing the formed precipitate with distilled water.

13. The method of making the 4-(2,4,5-tris(4-chlorophenyl)-1H-imidazol-1-yl)benzoic acid compound of claim 9 , wherein the 1,2-bis(4-chlorophenyl)ethane-1,2-dione, the 4-chlorobenzaldehyde, the 4-aminobenzoic acid, and the ammonium acetate are added in about a 1:1:1:1 molar ratio.