IP Library › Granted Patent US 12,310,890
Granted Patent B2
US 12,310,890 · App. 18/387,612 · Granted May 27, 2025

Punctal plug and bioadhesives

Inventors: Noah Silverberg (Santa Barbara, CA); Mark Silverberg (Santa Barbara, CA)
Assignee: Ocular Therapeutix, Inc.
A61F9/00772A61L31/04A61L31/148A61K9/0048A61L2430/16
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Quick Facts
Patent No.
US 12,310,890
App. No.
18/387,612
Granted
May 27, 2025
Kind
B2
Abstract

The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and/or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

Claims (4)

1. A method of treating an ophthalmological condition comprising:

(i) inserting a temporary lacrimal insert comprising a non-steroidal anti-inflammatory agent, a punctal plug portion and an intracanalicular portion into a punctum of an eye; wherein the punctal plug portion is configured to keep the intracanalicular portion from migrating into the lacrimal sac and wherein the intracanalicular portion is configured to prevent the punctal plug portion from extruding from the punctum; wherein the intracanalicular portion molds to a shape of a canaliculus; wherein the lacrimal insert comprises a biodegradable polymer; and wherein the time required for the lacrimal insert to adhere to tissue in the punctum sufficiently to stabilize the lacrimal insert in place is about 15 seconds to about 5 minutes; wherein the biodegradable polymer is not collagen or synthetic collagen; wherein the biodegradable polymer is selected from polyethylene glycol; polyethylenes; polyglycolides; polyhydroxyalkanoates; or any combination thereof; and wherein the lacrimal insert further comprises polyethylene glycol based hydrogel sealant disposed on a body surface oriented to contact the tissue of the punctum of a subject; and

(ii) occluding the punctum with the inserted lacrimal insert.

2. The method of claim 1 , wherein the non-steroidal anti-inflammatory agent is cyclosporine.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2024
From: VOOM LLC
To: OCULAR THERAPEUTIX, INC.
Reel/Frame 068365/0608 →
Continuity (4)
Continuation 17896434 · Aug 26, 2022
Continuation 15766647
Provisional Application 62239006 · Oct 8, 2015
Related Publication 20240148553A1 · May 9, 2024
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