Polyacrylic acid containing lubricious coatings for medical devices with enhanced properties
Embodiments herein relate to polyacrylic acid containing lubricious coatings for medical devices. In an embodiment, a lubricious coated medical device is included having a substrate and a first layer disposed over the substrate. The first layer can include a photoreactive polyvinylpyrrolidone, a non-photoreactive polyvinylpyrrolidone, and a crosslinking compound. A second layer can be disposed over the first layer, the second layer can include a poly(acrylic acid), and a non-photoreactive polyvinylpyrrolidone. The non-photoreactive polyvinylpyrrolidone of the second layer forms a complex with the poly(acrylic acid) of the second layer. The non-photoreactive polyvinylpyrrolidone of the second layer has a concentration existing as a gradient through a thickness of the second layer with a lower concentration at an outer surface of the second layer than at an inner surface of the second layer. Other embodiments are also included herein.
1. A lubricious coated medical device comprising:
a substrate; and
a first layer, wherein the first layer is disposed over the substrate, the first layer comprising
a photoreactive polyvinylpyrrolidone;
a first non-photoreactive polyvinylpyrrolidone;
a second non-photoreactive polyvinylpyrrolidone; and
a crosslinking compound;
a second layer, wherein the second layer is disposed over the first layer, the second layer comprising
a poly(acrylic acid); and
a third non-photoreactive polyvinylpyrrolidone.
2. The lubricious coated medical device of claim 1 , wherein the first layer has a thickness of 100 to 4000 nm.
3. The lubricious coated medical device of claim 1 , wherein the second layer has a thickness of less than 100 nm.
4. The lubricious coated medical device of claim 1 , further comprising a third layer;
wherein the third layer includes the same components as the first layer; and
wherein the third layer is disposed between the first layer and the second layer.
5. The lubricious coated medical device of claim 1 , further comprising a fourth layer;
wherein the fourth layer includes the same components as the second layer; and
wherein the fourth layer is disposed over the second layer.
6. The lubricious coated medical device of claim 1 , the crosslinking compound comprising bis(4-benzoylpheny) phosphate of a salt thereof.
7. The lubricious coated medical device of claim 1 , the crosslinking compound comprising sodium bis(4-benzoylpheny) phosphate.
8. The lubricious coated medical device of claim 1 , wherein the second layer is disposed directly on the first layer.
9. The lubricious coated medical device of claim 1 , the photoreactive polyvinylpyrrolidone comprising poly[vinyl pyrrolidone-co-N-(3-(4-benzoylbenzamideo) propyl) methacrylamide].
10. The lubricious coated medical device of claim 1 , wherein the lubricious coated medical device is a lubricious coated coronary or peripheral vasculature medical device.
11. The lubricious coated medical device of claim 1 , wherein the first non-photoreactive polyvinylpyrrolidone has an average molecular weight of 1000 kDa to 4000 kDa.
12. The lubricious coated medical device of claim 1 , wherein the second non-photoreactive polyvinylpyrrolidone has an average molecular weight of 30 to 70 kDa.
13. The lubricious coated medical device of claim 1 , wherein the third non-photoreactive polyvinylpyrrolidone has an average molecular weight of 3 kDa to 8 kDa.
14. A lubricious coated medical device comprising:
a substrate; and
a first layer, wherein the first layer is disposed over the substrate, the first layer comprising
a photoreactive polyvinylpyrrolidone;
a first non-photoreactive polyvinylpyrrolidone;
a second non-photoreactive polyvinylpyrrolidone;
a third non-photoreactive polyvinylpyrrolidone; and
a crosslinking compound;
a second layer, wherein the second layer is disposed over the first layer, the second layer comprising
a poly(acrylic acid);
a second photoreactive polyvinylpyrrolidone;
a fourth non-photoreactive polyvinylpyrrolidone;
a fifth non-photoreactive polyvinylpyrrolidone; and
a second cross-linking compound.
15. The lubricious coated medical device of claim 14 , wherein the first layer has a thickness of 100 to 4000 nm.
16. The lubricious coated medical device of claim 14 , wherein the second layer has a thickness of less than 100 nm.
17. The lubricious coated medical device of claim 14 , further comprising a third layer;
wherein the third layer includes the same components as the first layer; and
wherein the third layer is disposed between the first layer and the second layer.
18. The lubricious coated medical device of claim 14 , further comprising a fourth layer;
wherein the fourth layer includes the same components as the second layer; and
wherein the fourth layer is disposed over the second layer.
19. The lubricious coated medical device of claim 14 , the crosslinking compound comprising bis(4-benzoylpheny) phosphate of a salt thereof.
20. The lubricious coated medical device of claim 14 , the photoreactive polyvinylpyrrolidone comprising poly[vinyl pyrrolidone-co-N-(3-(4-benzoylbenzamideo) propyl) methacrylamide].