Granted Patent
B2
US 12,281,298 · App. 18/395,288 · Granted Apr 22, 2025
System for automated preparation of a regenerative epidermal suspension and related methods of use
Inventors:
Niraj Kumar Doshi (Valencia, CA); Jugal Kapadia (Valencia, CA); Matthew Krywcun (Laguna Niguel, CA); David Allen Fencil (Valencia, CA); David Melbye (Valencia, CA); Katie Bush (Marblehead, MA); Carl Swindle (San Clemente, CA); Paul Faucher (San Diego, CA); Matthew Richard Johnson (San Diego, CA); Adam Livingston (San Diego, CA); Michael MacCollum (San Diego, CA); Evan Misuraca (San Diego, CA); Kyle Stewart (San Diego, CA); Mikhail Tikh (San Diego, CA); Austin Wolf (San Diego, CA)
Assignee:
AVITA Medical Americas, LLC
C12M41/48B01L3/50255C12M3/02C12M3/08C12M21/08C12M23/12C12M23/38C12M23/42C12M23/50C12M25/04C12M27/10C12M33/00C12M33/14C12M41/18G01N1/286B01L2300/042G01N2001/2866
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Abstract
One or more systems for automated preparation of a regenerative epidermal suspension comprises a base unit, a cartridge assembly containing a cup, and a tissue disaggregator. The system may also include related tools. The system executes one or more sequences wherein a first motor actuates the pestle against a tissue sample that is disposed along a screen within the cup while the tissue sample is in contact with, in sequence, an enzyme solution, a first buffer solution, and then a second buffer solution. To transition between fluidic contact stages or steps, the tissue disaggregator engages with and lifts the cup into a raised position within a processing area of the cartridge while a base plate motor rotates the appropriate well into alignment under the cup for each processing step. Once the sequence is complete, a user may draw up a regenerative epidermal suspension through an opening in the cartridge top cover.
Claims (25)
1. A system for automated preparation of a regenerative epidermal suspension, comprising:
a base unit comprising a tissue processing area;
a cartridge configured to be received in the tissue processing area, comprising:
a cover comprising a raised processing opening configured to receive a cup, and
a well plate situated under the cover and configured to rotate relative to the cover;
a cup configured to be lowered and raised into a well of the well plate;
a tissue disaggregator configured to mechanically separate tissue when a tissue sample is positioned within the cup; and
a processor configured to rotate the well plate.
2. The system of claim 1 , further comprising a heating element disposed within the base unit.
3. The system of claim 2 , wherein the heating element is configured to produce heat sufficient to improve enzyme efficiency of an enzyme positioned within the well plate.
4. The system of claim 1 , wherein the tissue disaggregator comprises a pestle.
5. The system of claim 1 , wherein the base unit comprises a tissue disaggregator shaft.
6. The system of claim 5 , wherein the disaggregator shaft is configured to be attached to the tissue disaggregator.
7. The system of claim 1 , wherein the cup comprises a screen disposed within the cup.
8. The system of claim 7 , wherein the screen is transversely oriented within the cup.
9. The system of claim 7 , wherein the opening comprises a raised portion and is configured to receive the cup.
10. The system of claim 1 , wherein the well plate comprises a well and the well plate is configured to rotate to align the well with the opening.
11. The system of claim 9 , wherein the well plate comprises a plurality of wells and the well plate is configured to rotate to align each of the wells with the opening.
12. The system of claim 11 , wherein the well plate comprises a buffer well configured to receive a buffer and an enzyme well configured to receive an enzyme.
13. The system of claim 12 , wherein the well plate is configured to rotate to position the enzyme well under the opening when enzyme is to be used to disaggregate a tissue.
14. The system of claim 12 , wherein the well plate is configured to rotate to position the buffer well under the opening when buffer is to be applied to the tissue.
15. The system of claim 1 , wherein the processor is configured to operate the tissue disaggregator and raise and lower the cup.
16. The system of claim 7 , wherein the cartridge comprises the cup.
17. The system of claim 7 , wherein a solution in a well may pass through the screen and contact the tissue sample.
18. The system of claim 1 , wherein the at least one well is configured to retain 1 mL to 500 mL of a solution.
Assignments (4)
RELEASE OF SECURITY INTEREST
Recorded Jan 14, 2026
From: ORCO IV LLC
To: AVITA MEDICAL AMERICAS, LLC
Reel/Frame 073473/0540 →
SECURITY INTEREST
Recorded Jan 13, 2026
From: AVITA MEDICAL, INC.; AVITA MEDICAL AMERICAS, LLC
To: PERCEPTIVE CREDIT HOLDINGS V, LP
Reel/Frame 073458/0492 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 7, 2024
From: DOSHI, NIRAJ KUMAR; KAPADIA, JUGAL; KRYWCUN, MATTHEW; FENCIL, DAVID; MELBYE, DAVID; BUSH, KATIE; SWINDLE, CARL; FAUCHER, PAUL; JOHNSON, MATTHEW RICHARD; LIVINGSTON, ADAM; MACCOLLUM, MICHAEL; MISURACA, EVAN; STEWART, KYLE; TIKH, MIKHAIL; WOLF, AUSTIN
To: AVITA MEDICAL AMERICAS, LLC
Reel/Frame 069325/0977 →
SECURITY INTEREST
Recorded Apr 1, 2024
From: AVITA MEDICAL AMERICAS, LLC
To: ORCO IV LLC
Reel/Frame 066960/0144 →
Continuity (3)
Provisional Application
63533586
· Aug 18, 2023
Provisional Application
63435446
· Dec 27, 2022
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· 2024
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