IP Library Granted Patent US 12,465,414
Granted Patent B2
US 12,465,414 · App. 18/404,033 · Granted Nov 11, 2025

Tissue ablation systems and method

Inventors: Akos Toth (Cupertino, CA); Csaba Truckai (Saratoga, CA)
Assignee: HERMES INNOVATIONS LLC
A61B18/042A61B18/1206A61B18/1492A61B2018/00577A61B2018/00589A61B2018/00702A61B2018/00791A61B2018/00875A61B2018/122
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Quick Facts
Patent No.
US 12,465,414
App. No.
18/404,033
Granted
Nov 11, 2025
Kind
B2
Abstract

Tissue is treated using a radiofrequency power supply connected to an applicator having a chamber filled with an electrically non-conductive gas surrounded by a thin dielectric wall. A radiofrequency voltage is applied at a level sufficient to ionize the gas into a plasma and to capacitively couple the ionized plasma with the tissue to deliver radiofrequency current to ablate or otherwise treat the tissue.

Claims (31)

1 . A method of applying energy to tissue, said method comprising:

engaging a dielectric wall against the tissue, the dielectric wall defining a chamber therein;

delivering an electrically non-conductive gas into the chamber;

applying a voltage between a first electrode and a second electrode to initiate ionization of the gas into a plasma completely contained within the chamber and separated from the tissue by the dielectric wall; and

capacitively coupling the plasma across the dielectric wall and into the tissue.

2 . The method of claim 1 , wherein the first electrode is positioned within the chamber.

3 . The method of claim 2 , wherein the second electrode is posited exterior of the chamber.

4 . The method of claim 1 , wherein the step of delivering the electrically non-conductive gas into the chamber includes providing a continuous flow of the gas into the chamber.

5 . The method of claim 4 , wherein the gas is provided at a flow rate of 5 ml/sec. to 30 ml/sec.

6 . The method of claim 1 , wherein the voltage is at least 100 volts.

7 . The method of claim 1 , wherein the dielectric wall is formed of a conformable silicone.

8 . The method of claim 1 , wherein the dielectric wall has a thickness in a range of 0.004 inches to 0.03 inches.

9 . The method of claim 1 , wherein a frame is provided within the chamber.

10 . The method of claim 9 , further comprising:

expanding the frame to open the dielectric wall.

11 . The method of claim 1 , further comprising:

ablating the tissue.

12 . The method of claim 11 , wherein the tissue is ablated to a depth of 1 mm to 5 mm.

13 . The method of claim 1 , wherein the dielectric wall is coupled to an elongate shaft.

14 . The method of claim 13 , wherein the gas flows through the elongate shaft into the chamber.

15 . The method of claim 1 , wherein the gas is argon.

16 . A method of applying energy to tissue, said method comprising:

engaging a dielectric wall against the tissue, the dielectric wall defining a chamber therein;

delivering an electrically non-conductive gas into the chamber;

passing a radiofrequency energy between a first electrode within the chamber and a second electrode exterior of the chamber to initiate ionization of the gas into a plasma completely contained within the chamber and separated from the tissue by the dielectric wall; and

ablating the tissue with the radiofrequency energy.

17 . The method of claim 16 , wherein the tissue is ablated to a depth of 1 mm to 5 mm.

18 . The method of claim 16 , wherein the step of delivering the electrically non-conductive gas into the chamber includes providing a continuous flow of the gas into the chamber.

19 . The method of claim 16 , wherein a frame is provided within the chamber.

20 . The method of claim 19 , further comprising:

expanding the frame to open the dielectric wall.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 12, 2026
From: MINERVA SURGICAL, INC.
To: AXORA MEDICAL, INC.
Reel/Frame 075561/0141 →