LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
1 - 20 . (canceled)
21 . A coating for a medical device comprising:
a non-derivatized polyvinylpyrrolidone;
polyvinylpyrrolidone derivatized with a photoreactive group; and
a cross-linking agent comprising at least two photoreactive groups.
22 . The coating for a medical device of claim 21 , further comprising a polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits.
23 . The coating for a medical device of claim 21 , wherein the polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits further comprises a photoreactive group.
24 . The coating for a medical device of claim 22 , the photoreactive group comprising a benzophenone group.
25 . The coating for a medical device of claim 21 , wherein the polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits comprises N-Acetylated poly [acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido) propyl) methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate.
26 . The coating for a medical device of claim 21 , wherein the underivatized polyvinylpyrrolidone comprises PVP-K90.
27 . The coating for a medical device of claim 21 , the cross-linking agent comprising an anionic group.
28 . The coating for a medical device of claim 21 , the cross-linking agent comprising a phosphate group.
29 . The coating for a medical device of claim 21 , the cross-linking agent comprising sodium bis(4-benzoylphenyl) phosphate.
30 . The coating for a medical device of claim 21 , wherein the polyvinylpyrrolidone derivatized with a photoreactive group is derivatized with a benzophenone group.
31 . The coating for a medical device of claim 21 , wherein the coating releases less than 10,000 particles greater than 10 microns in size when exposed to an aqueous environment.
32 . The coating for a medical device of claim 21 , wherein the coating releases less than 10,000 particles greater than 10 microns in size per square centimeter of coating surface area when exposed to an aqueous environment.
33 . The coating for a medical device of claim 21 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force.
34 . The coating for a medical device of claim 21 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force for at least 10 consecutive testing cycles.
35 . The coating for a medical device of claim 21 , the coating exhibiting a durability of lubricity such there is less than a 30 percent increase in measured friction between the average of cycles 1-5 of testing and cycles 10-15 of testing.
36 . The coating for a medical device of claim 21 , wherein the coating is between about 100 and 3000 nm when dry.
37 . A medical device comprising:
a coating, the coating comprising
a non-derivatized polyvinylpyrrolidone;
polyvinylpyrrolidone derivatized with a photoreactive group; and
a cross-linking agent comprising at least two photoreactive groups.
38 . The medical device of claim 37 , the coating further comprising a polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits.
39 . The medical device of claim 38 , wherein the polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits further comprises a photoreactive group.
40 . The medical device of claim 38 , wherein the polymer comprising polyacrylamide, 2-acrylamido-2-methylpropanesulfonate (AMPS), and polyethyleneglycol subunits comprises N-Acetylated poly [acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido) propyl) methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate.