IP Library Granted Patent US 12,226,616
Granted Patent B2
US 12,226,616 · App. 18/415,452 · Granted Feb 18, 2025

Auto injector with adaptable air-shot mechanism

Inventors: Per Mølgaard Pedersen (Struer, DK); Flemming Madsen (Aalborg SV, DK); Sven Erik Poulsen (Skive, DK); Steen Jensen (Dragør, DK); Henrik Egesborg (Hellerup, DK)
Assignee: Ascendis Pharma A/S
A61M5/3146A61M5/20A61M5/24A61M5/31511A61M2005/2411A61M2205/215A61M2205/3368A61M2205/6018A61M2205/6054A61M2205/6063A61M2205/6072
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Quick Facts
Patent No.
US 12,226,616
App. No.
18/415,452
Granted
Feb 18, 2025
Kind
B2
Abstract

Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge and a cartridge code feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.

Claims (40)

1. An auto injector for administering a medicament, comprising:

a housing;

a cartridge receiver configured to receive a cartridge assembly comprising a cartridge and a cartridge code feature, wherein the cartridge contains the medicament;

a code sensor configured to read the cartridge code feature;

a drive module coupled to move a plunger rod;

a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod and a processing unit coupled to the code sensor, the drive module and to the resistance sensor;

wherein the processing unit is configured to:

receive the resistance signal and determine the resistance against movement of the plunger rod based on the resistance signal;

receive from the code sensor a code signal indicative of the cartridge code feature; and

control the drive module to move the plunger rod to a first plunger rod position based on the resistance signal, wherein the first plunger rod position is based on the code signal, and wherein the first plunger rod position is selected to expel air from the cartridge.

2. The auto injector according to claim 1 , wherein the resistance sensor is configured to detect the electrical current of a motor of the drive module.

3. The auto injector according to claim 1 , wherein the processing unit is configured to control the drive module to adjust movement of the plunger rod based on the resistance signal.

4. The auto injector according to claim 1 , wherein the processing unit is configured to control the drive module to start, stop or continue movement of the plunger rod based on the resistance signal.

5. The auto injector according to claim 1 , wherein the processing unit is configured to move the plunger rod based on the cartridge code feature.

6. The auto injector according to claim 5 , wherein the cartridge code feature is indicative of the viscosity of the medicament in the cartridge.

7. The auto injector according claim 1 , wherein the code sensor comprises an optical sensor.

8. The auto injector according to claim 1 , wherein the cartridge code feature comprises one or more of a colour, a bar code, an RFID tag, an NFC tag, an identification number, or a QR code.

9. The auto injector according to claim 1 , further comprising a temperature sensor configured to provide a temperature signal indicative of the temperature of the auto injector and/or of the cartridge and/or of the medicament, wherein the processing unit is coupled to the temperature sensor and configured to receive the temperature signal, and wherein the processing unit is configured to control the drive module to move the plunger rod to the first plunger rod position based on the temperature signal.

10. The auto injector according to claim 1 , further comprising an orientation sensor, wherein the processing unit is coupled to the orientation sensor, wherein the processing unit is configured to receive from the orientation sensor an orientation signal indicative of the orientation of the cartridge when received in the cartridge receiver, and wherein the processing unit is configured to control the drive module to move the plunger rod to the first plunger rod position based on the orientation signal.

11. The auto injector according to claim 10 , wherein the orientation sensor comprises an accelerometer.

12. The auto injector according to claim 10 , wherein the processing unit is configured to control the drive module to move the plunger rod to the first plunger rod position if the orientation signal indicates that a tilt between vertical and a longitudinal axis extending along the cartridge is within 45 degrees of vertical and a cartridge outlet of the cartridge is in a vertical position above a cartridge compartment of the cartridge, wherein the cartridge compartment contains the medicament.

13. The auto injector according to claim 1 , wherein the plunger rod is moved to the first plunger rod position with a first plunger rod speed based on the code signal.

14. A cartridge assembly for an auto injector comprising a cartridge and a cartridge code feature, wherein the cartridge contains a medicament, wherein the cartridge code feature is configured to be read by a code sensor of the auto injector for moving a plunger rod of the auto injector to a first plunger rod position based on the cartridge code feature, and wherein the first plunger rod position is selected to expel air from the cartridge.

15. The cartridge assembly according to claim 14 , wherein the cartridge comprises a cartridge compartment containing the medicament, a cartridge outlet, and a first stopper movable inside the cartridge compartment towards the cartridge outlet, wherein the cartridge code feature is indicative of a position of the first stopper wherein air in the cartridge compartment is reduced.

16. The cartridge assembly according to claim 14 , wherein the cartridge code feature is further indicative of the viscosity of the medicament in the cartridge.

17. A system comprising a cartridge assembly and an auto injector, wherein the cartridge assembly comprises a cartridge and a cartridge code feature, wherein the cartridge contains a medicament, and wherein the auto injector comprises:

a housing;

a cartridge receiver configured to receive the cartridge assembly;

a code sensor configured to read the cartridge code feature;

a drive module coupled to move a plunger rod;

a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod and a processing unit coupled to the code sensor, the resistance sensor and the drive module;

wherein the processing unit is configured to:

receive the resistance signal and determine the resistance against movement of the plunger rod based on the resistance signal;

receive from the code sensor a code signal indicative of the cartridge code feature; and

control the drive module to move the plunger rod to a first plunger rod position based on the resistance signal, the first plunger rod position being based on the code signal, and the first plunger rod position being selected to expel air from the cartridge.

18. A method for operating an auto injector comprising a plunger rod, the method comprising:

receiving a cartridge assembly comprising a cartridge and a cartridge code feature, wherein the cartridge contains a medicament;

reading the cartridge code feature;

receiving a resistance signal and determining a resistance against movement of a plunger rod based on the resistance signal; and

moving the plunger rod to a first plunger rod position based on the resistance signal, wherein the first plunger rod position is based on the cartridge code feature, and wherein the first plunger rod position is selected to expel air from the cartridge.

Assignments (3)
CHANGE OF ADDRESS Recorded Apr 7, 2025
From: ASCENDIS PHARMA A/S
To: ASCENDIS PHARMA A/S
Reel/Frame 070750/0806 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2025
From: MEDICOM INNOVATION PARTNER A/S
To: ASCENDIS PHARMA A/S
Reel/Frame 069897/0228 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2025
From: PEDERSEN, PER MOLGAARD; MADSEN, FLEMMING; POULSEN, SVEN ERIK; JENSEN, STEEN; EGESBORG, HENRIK
To: MEDICOM INNOVATION PARTNER A/S
Reel/Frame 070498/0322 →
Priority Claims (1)
EP 15203171 · Dec 30, 2015 · regional
Continuity (3)
Continuation 17816360 · Jul 29, 2022
Continuation 16060606
Related Publication 20240165336A1 · May 23, 2024
References Cited (226)
US 4024864A · Davies · 1977 [cited by applicant]
US 4394863A · Bartner · 1983 [cited by applicant]
US 4677980A · Reilly et al. · 1987 [cited by applicant]
US 5739508A · Uber, III · 1998 [cited by applicant]
US 5808203A · Nolan, Jr. et al. · 1998 [cited by applicant]
US 6368314B1 · Kipfer et al. · 2002 [cited by applicant]
US 9173995B1 · Tucker · 2015 [cited by applicant]
US 10384031B1 · Acker et al. · 2019 [cited by applicant]
US 10835677B2 · Fabricius et al. · 2020 [cited by applicant]
US 11179524B2 · Pedersen et al. · 2021 [cited by applicant]
US 11351305B2 · Pedersen et al. · 2022 [cited by applicant]
US 11406760B2 · Olesen et al. · 2022 [cited by applicant]
US 11517673B2 · Pedersen · 2022 [cited by examiner]
US 11524115B2 · Jacobsen et al. · 2022 [cited by applicant]
US 11607496B2 · Fabricius et al. · 2023 [cited by applicant]
US 11684724B2 · Egesborg et al. · 2023 [cited by applicant]
US 11738147B2 · Olesen et al. · 2023 [cited by applicant]
US 11969581B2 · Pedersen · 2024 [cited by examiner]
US 12005241B2 · Pedersen et al. · 2024 [cited by applicant]
US 20020016573A1 · Munk · 2002 [cited by applicant]
US 20020107477A1 · Kipfer · 2002 [cited by applicant]
US 20030083626A1 · Munk · 2003 [cited by examiner]
US 20030205587A1 · Tribe · 2003 [cited by applicant]
US 20050261634A1 · Karlsson · 2005 [cited by applicant]
US 20060178630A1 · Bostrom et al. · 2006 [cited by applicant]
US 20090036846A1 · Dacquay et al. · 2009 [cited by applicant]
US 20090209883A1 · Higgins et al. · 2009 [cited by applicant]
US 20090299328A1 · Mudd et al. · 2009 [cited by applicant]
US 20100069842A1 · Dos Santos et al. · 2010 [cited by applicant]
US 20100094309A1 · Boukhny et al. · 2010 [cited by applicant]
US 20100211005A1 · Edwards et al. · 2010 [cited by applicant]
US 20110313395A1 · Krulevitch · 2011 [cited by examiner]
US 20120078185A1 · Smith et al. · 2012 [cited by applicant]
US 20120204997A1 · Winn et al. · 2012 [cited by applicant]
US 20120283655A1 · Plumptre et al. · 2012 [cited by applicant]
US 20130079708A1 · Wiimpenny et al. · 2013 [cited by applicant]
US 20130193073A1 · Hogard et al. · 2013 [cited by applicant]
US 20130211326A1 · Dasbach et al. · 2013 [cited by applicant]
US 20130211327A1 · Osman et al. · 2013 [cited by applicant]
US 20130226134A1 · Schabbach et al. · 2013 [cited by applicant]
US 20130245545A1 · Arnold et al. · 2013 [cited by applicant]
US 20130281965A1 · Kamen et al. · 2013 [cited by applicant]
US 20130296807A1 · Lintern et al. · 2013 [cited by applicant]
US 20140012229A1 · Bokelman et al. · 2014 [cited by applicant]
US 20140114277A1 · Eggert · 2014 [cited by examiner]
US 20140142514A1 · Elahi et al. · 2014 [cited by applicant]
US 20140166915A1 · Ishibashi et al. · 2014 [cited by applicant]
US 20140188076A1 · Kamen et al. · 2014 [cited by applicant]
US 20140193788A1 · Groves et al. · 2014 [cited by applicant]
US 20140207106A1 · Bechmann et al. · 2014 [cited by applicant]
US 20140221925A1 · Kondoh et al. · 2014 [cited by applicant]
US 20140358093A1 · Soerensen et al. · 2014 [cited by applicant]
US 20150045729A1 · Denzer et al. · 2015 [cited by applicant]
US 20150051538A1 · Hata et al. · 2015 [cited by applicant]
US 20150088089A1 · Bartlett, II et al. · 2015 [cited by applicant]
US 20150122338A1 · Hunter et al. · 2015 [cited by applicant]
US 20150231334A1 · Buchine et al. · 2015 [cited by applicant]
US 20150306316A1 · Bruggemann · 2015 [cited by applicant]
US 20150320932A1 · Draper et al. · 2015 [cited by applicant]
US 20150359967A1 · Steel et al. · 2015 [cited by applicant]
US 20150367074A1 · Draper et al. · 2015 [cited by applicant]
US 20150367075A1 · Cave · 2015 [cited by applicant]
US 20150374930A1 · Hyde et al. · 2015 [cited by applicant]
US 20170119969A1 · McCullough et al. · 2017 [cited by applicant]
US 20170196702A1 · Agarwal · 2017 [cited by applicant]
US 20180094309A1 · Boukhany · 2018 [cited by applicant]
US 20180236181A1 · Marlin et al. · 2018 [cited by applicant]
US 20190009029A1 · Fabricius et al. · 2019 [cited by applicant]
US 20200384207A1 · Egesborg et al. · 2020 [cited by applicant]
US 20220152310A1 · Pedersen et al. · 2022 [cited by applicant]
US 20220288316A1 · Olesen et al. · 2022 [cited by applicant]
US 20230016657A1 · Pedersen et al. · 2023 [cited by applicant]
US 20230072178A1 · Jacobsen et al. · 2023 [cited by applicant]
US 20230090661A1 · Jensen et al. · 2023 [cited by applicant]
US 20230263961A1 · Egesborg et al. · 2023 [cited by applicant]
US 20230270945A1 · Fabricius et al. · 2023 [cited by applicant]
US 20230338659A1 · Olesen et al. · 2023 [cited by applicant]
US 20240082494A1 · Jensen et al. · 2024 [cited by applicant]
US 20240277944A1 · Pedersen et al. · 2024 [cited by applicant]
CN 101905048 · 2010 [cited by applicant]
CN 102413855 · 2012 [cited by applicant]
CN 102740907 · 2012 [cited by applicant]
CN 103813820 · 2014 [cited by applicant]
CN 105492047 · 2016 [cited by applicant]
EP 2656865 · 2013 [cited by applicant]
EP 2675500 · 2013 [cited by applicant]
EP 2777731 · 2014 [cited by applicant]
EP 2923715 · 2015 [cited by applicant]
GB 2356349 · 2001 [cited by applicant]
GB 2506918 · 2014 [cited by applicant]
JP H11513586 · 1999 [cited by applicant]
JP 2000513973 · 2000 [cited by applicant]
JP 2005503202 · 2005 [cited by applicant]
JP 2005080832 · 2005 [cited by applicant]
JP 2007500531 · 2007 [cited by applicant]
JP 2008531235 · 2008 [cited by applicant]
JP 2009148591 · 2009 [cited by applicant]
JP 2009279438 · 2009 [cited by applicant]
JP 2010506681 · 2010 [cited by applicant]
JP 2010510011 · 2010 [cited by applicant]
JP 2010523181 · 2010 [cited by applicant]
JP 2011507668 · 2011 [cited by applicant]
JP 2011521744 · 2011 [cited by applicant]
JP 2011240159 · 2011 [cited by applicant]
JP 2012505066 · 2012 [cited by applicant]
JP 2012066767 · 2012 [cited by applicant]
JP 2012516737 · 2012 [cited by applicant]
JP 2012519028A · 2012 [cited by applicant]
JP 2013506444 · 2013 [cited by applicant]
JP 2013069305 · 2013 [cited by applicant]
JP 2013075154 · 2013 [cited by applicant]
JP 2013537844 · 2013 [cited by applicant]
JP 2014500746 · 2014 [cited by applicant]
JP 2014502890 · 2014 [cited by applicant]
JP 2014503279 · 2014 [cited by applicant]
JP 2014506159 · 2014 [cited by applicant]
JP 2014507223 · 2014 [cited by applicant]
JP 2014515941 · 2014 [cited by applicant]
JP 2014516700 · 2014 [cited by applicant]
JP 2014516702 · 2014 [cited by applicant]
JP 2014521113 · 2014 [cited by applicant]
JP 20144528787 · 2014 [cited by applicant]
JP 2015521920 · 2015 [cited by applicant]
JP 2015163208 · 2015 [cited by applicant]
JP 2016208611 · 2016 [cited by applicant]
JP 2001513371 · 2021 [cited by applicant]
KR 1020150125701 · 2015 [cited by applicant]
KR B101666755 · 2016 [cited by applicant]
KR 1020170013870 · 2017 [cited by applicant]
PT 3397321 · 2022 [cited by applicant]
RU 2014120469 · 2015 [cited by applicant]
WO WO2002051471 · 2002 [cited by applicant]
WO WO2005102416 · 2005 [cited by applicant]
WO WO2006116997 · 2006 [cited by applicant]
WO WO2008062025 · 2008 [cited by applicant]
WO WO2006059597 · 2008 [cited by applicant]
WO WO2010098927 · 2010 [cited by applicant]
WO WO2010098931 · 2010 [cited by applicant]
WO WO2012112347 · 2012 [cited by applicant]
WO WO2010100883 · 2012 [cited by applicant]
WO WO2012160157 · 2012 [cited by applicant]
WO WO2013065055 · 2013 [cited by applicant]
WO WO2013138830 · 2013 [cited by applicant]
WO WO2014008393 · 2014 [cited by applicant]
WO WO2012066767 · 2014 [cited by applicant]
WO WO2014118106 · 2014 [cited by applicant]
WO WO2014118109 · 2014 [cited by applicant]
WO WO2014118110 · 2014 [cited by applicant]
WO WO2014144096 · 2014 [cited by applicant]
WO WO2014166915 · 2014 [cited by applicant]
WO WO2014168205 · 2014 [cited by applicant]
WO WO2014187812 · 2014 [cited by applicant]
WO WO2014187813 · 2014 [cited by applicant]
WO WO2015006430 · 2015 [cited by applicant]
WO WO2013069305 · 2015 [cited by applicant]
WO WO2015055640 · 2015 [cited by applicant]
WO WO2015055642 · 2015 [cited by applicant]
WO WO2015115326 · 2015 [cited by applicant]
WO WO2015187797 · 2015 [cited by applicant]
WO WO2016005421 · 2016 [cited by applicant]
WO WO2016033507 · 2016 [cited by applicant]
WO WO2016098060 · 2016 [cited by applicant]
WO WO2014091765 · 2017 [cited by applicant]
WO WO2017009724 · 2017 [cited by applicant]
WO WO2017114906 · 2017 [cited by applicant]
WO WO2017114907 · 2017 [cited by applicant]
WO WO2017114908 · 2017 [cited by applicant]
WO WO2017114909 · 2017 [cited by applicant]
WO WO2017114910 · 2017 [cited by applicant]
WO WO2017114911 · 2017 [cited by applicant]
WO WO2017114912 · 2017 [cited by applicant]
WO WO2018215516 · 2018 [cited by applicant]
WO WO2019002534 · 2019 [cited by applicant]
WO WO2020176319 · 2020 [cited by applicant]
WO WO2023052487 · 2023 [cited by applicant]
US 11,957,880 B2, 04/2024, Jensen et al. (withdrawn) [cited by applicant]
English Translation of Office Action dated Jun. 3, 2021, in Corresponding Chinese Application No. 201880043795.0. [cited by applicant]
English Translation of Office Action dated Jul. 9, 2021, in corresponding Russian Application No. 2019140269. [cited by applicant]
English Translation of Office Action dated Jul. 30, 2021, in corresponding Russian Application No. 2020103216. [cited by applicant]
English Translation of Office Action dated Jun. 10, 2021, in corresponding Chinese Application No. 201880033657.4. [cited by applicant]
English translation of Office Action issued in Japanese Application No. 2019-565323, dated Jan. 5, 2022. [cited by applicant]
English translation of Office Action issued in Japanese Application No. 2019-570894, dated Jan. 13, 2022. [cited by applicant]
English translation of Office Action issued in Chinese Application No. 201880033657, dated Feb. 23, 2022. [cited by applicant]
English translation of Office Action issued in Japanese Application No. 2021-116315, dated Sep. 2, 2022. [cited by applicant]
English translation of Office Action issued in Korean Application No. 10-2020-7000564, dated Oct. 17, 2022. [cited by applicant]
European Search Report for EP 15203132.4, dated Jun. 29, 2016. [cited by applicant]
European Search Report for EP 15203137.3, dated Jul. 1, 2016. [cited by applicant]
Partial European Search Report for EP15203168.8, dated Sep. 16, 2016. [cited by applicant]
European Search Report for EP 18733296.0, dated Feb. 1, 2023, in 5 pages. [cited by applicant]
International Search Report for PCT/EP2016/082861, dated Mar. 22, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082861, mailed Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082856, mailed on Mar. 28, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082856, mailed Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082860, mailed on May 3, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082860, mailed on Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082858, mailed Mar. 24, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082858, mailed on Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082855, mailed Mar. 24, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082855, mailed on Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082857, mailed May 12, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082857, mailed on Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2016/082859, mailed on Apr. 10, 2017. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2016/082859, mailed on Jul. 12, 2018. [cited by applicant]
International Search Report for PCT/EP2018/063460, mailed on Mar. 7, 2018. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2018/063460, mailed on Dec. 5, 2019. [cited by applicant]
International Search Report for PCT/EP2018/067532, mailed on Sep. 25, 2018. [cited by applicant]
International Preliminary Report on Patentability for PCT/EP2018/067532, mailed on Jan. 9, 2020. [cited by applicant]
Office Action in Canadian Application No. 3,006,626, dated Dec. 19, 2022, in 5 pages. [cited by applicant]
Office Action in Canadian Application No. 3,006,616, dated Dec. 19, 2022, in 3 pages. [cited by applicant]
Office Action in Canadian Application No. 3,006,638, dated Jan. 17, 2023, in 4 pages. [cited by applicant]
Office Action in Canadian Application No. 3,006,627, dated Dec. 30, 2022, in 5 pages. [cited by applicant]
Office Action in Canadian Application No. 3,006,643, dated Jan. 4, 2023, in 7 pages. [cited by applicant]
Office Action in Canadian Application No. 3,006,622, dated Jan. 4, 2023, in 4 pages. [cited by applicant]
Office Action in New Zealand Application No. 742523, dated Feb. 27, 2023, in 3 pages. [cited by applicant]
Office Action in New Zealand Application No. 742538, dated Mar. 8, 2023, in 9 pages. [cited by applicant]
Office Action in New Zealand Application No. 742526, dated Mar. 13, 2023, in 8 pages. [cited by applicant]
Office Action in Australian Application No. 2018-294519, dated Mar. 10, 2023, in 3 pages. [cited by applicant]
English translation of Office Action issued in Japanese Application No. JP 2022-074131, dated Apr. 28, 2023, in 2 pages. [cited by applicant]
English translation of Office Action issued in Japanese Application No. JP 2021-116315, dated Apr. 25, 2023, in 3 pages. [cited by applicant]
Office Action in New Zealand Application No. 742526, dated Jul. 6, 2023, in 10 pages. [cited by applicant]
Office Action in Canadian Application No. 3,064,056, dated Jul. 11, 2023, in 5 pages. [cited by applicant]
English translation of Office Action issued in Japanese Application No. JP 2023-021789, dated Nov. 7, 2023, in 5 pages. [cited by applicant]
Hearing Notice dispatched on Dec. 29, 2023 in India Patent Application No. 201947041763. [cited by applicant]
Office Action with English translation in Korean application No. 10-2023-7043623, dated Apr. 18, 2024, in 12 pages. [cited by applicant]
Office Action with English translation in Japanese Application No. JP 2023-140873, mailed on Jun. 28, 2024, in 11 pages. [cited by applicant]
Office Action with English translation issued in Japanese application No. 2024-014677, mailed on Sep. 12, 2024, in 5 pages. [cited by applicant]