IP Library › Granted Patent US 12,383,469
Granted Patent B2
US 12,383,469 · App. 18/416,815 · Granted Aug 12, 2025

Pressure-regulating vial adaptors

Inventor: Thomas F. Fangrow (Mission Viejo, CA)
Assignee: ICU Medical, Inc.
A61J1/2096A61J1/201A61J1/2048A61J1/2075A61J1/2082A61J1/2086B65B3/003A61J1/10Y10T29/49826
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Quick Facts
Patent No.
US 12,383,469
App. No.
18/416,815
Granted
Aug 12, 2025
Kind
B2
Abstract

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

Claims (43)

1. A pressure-regulating vial adapter comprising:

a housing configured to couple with a vial having a septum, the housing comprising a piercing member that is configured to be inserted through the septum of the vial in a distal direction, the piercing member having a distal tip;

a rigid enclosure comprising an internal space; and

a reservoir comprising a first flexible side and a second flexible side, the reservoir configured to inflate in the distal direction from a deflated state to an inflated state in response to regulating fluid being received between the first and second flexible sides, the reservoir substantially centered with respect to an axial center of the pressure-regulating vial adaptor;

wherein, in the deflated state and with the housing coupled with the vial, the entirety of the reservoir is positioned in the internal space of the rigid enclosure and outside of the vial; and

wherein, during inflation from the deflated state to the inflated state, a portion of the reservoir expands out of the rigid enclosure, such that some of the reservoir is in the rigid enclosure and some of the reservoir is not in the rigid enclosure.

2. The pressure-regulating vial adapter of claim 1 , wherein the reservoir is annular.

3. The pressure-regulating vial adapter of claim 1 , wherein the reservoir comprises a bag.

4. The pressure-regulating vial adapter of claim 1 , wherein, in response to regulating fluid being withdrawn from between the first and second flexible sides, the reservoir crumples.

5. The pressure-regulating vial adapter of claim 1 , wherein the first flexible side is made of a first sheet of material and the second flexible side is made of a second sheet of material, the first and second sheets connected at a peripheral edge.

6. The pressure-regulating vial adapter of claim 1 , wherein the reservoir comprises an annular ring.

7. The pressure-regulating vial adapter of claim 6 , wherein the annular ring is rigid.

8. The pressure-regulating vial adapter of claim 1 , wherein the reservoir comprises a peripheral portion connecting the first flexible side and the second flexible side.

9. The pressure-regulating vial adapter of claim 8 , wherein the peripheral portion is rigid.

10. The pressure-regulating vial adapter of claim 9 , wherein the peripheral portion is annular.

11. The pressure-regulating vial adapter of claim 1 , wherein the first flexible side and the second flexible side are configured to unfold to increase the volume of the reservoir and to crumple to decrease the volume of the reservoir.

12. The pressure-regulating vial adapter of claim 1 , wherein, during inflation from the deflated state to the inflated state, a bottommost end of the reservoir expands toward the vial.

13. The pressure-regulating vial adapter of claim 1 , wherein, in the deflated state and with the housing coupled with the vial, a bottom of the reservoir is above a top of the vial.

14. The pressure-regulating vial adapter of claim 1 , wherein the piercing member comprises a regulating channel configured to convey the regulating fluid and an access channel configured to convey a medicinal liquid.

15. A pressure-regulating vial adapter comprising:

a housing configured to couple with a vial having a septum, the housing comprising a piercing member that is configured to be inserted through the septum of the vial in a distal direction, the piercing member having a distal tip;

a rigid enclosure comprising an internal space; and

an annular reservoir comprising a first flexible side and a second flexible side, the reservoir configured to inflate in the distal direction from a deflated state to an inflated state in response to regulating fluid being received between the first and second flexible sides;

wherein, in the deflated state and with the housing coupled with the vial, the entirety of the reservoir is positioned in the internal space of the rigid enclosure and outside of the vial; and

wherein, during inflation from the deflated state to the inflated state, a portion of the reservoir expands out of the rigid enclosure, such that some of the reservoir is in the rigid enclosure and some of the reservoir is not in the rigid enclosure.

16. The pressure-regulating vial adapter of claim 15 , wherein, in response to regulating fluid being withdrawn from between the first and second flexible sides, the reservoir crumples.

17. The pressure-regulating vial adapter of claim 15 , wherein the first flexible side is made of a first sheet of material and the second flexible side is made of a second sheet of material, the first and second sheets connected at a peripheral edge.

18. The pressure-regulating vial adapter of claim 15 , wherein the first flexible side and the second flexible side are configured to unfold to increase the volume of the reservoir and to crumple to decrease the volume of the reservoir.

19. The pressure-regulating vial adapter of claim 15 , wherein, during inflation from the deflated state to the inflated state, a bottom end of the reservoir expands toward the vial.

20. The pressure-regulating vial adapter of claim 15 , wherein the reservoir is substantially centered with respect to an axial center of the pressure-regulating vial adaptor.

21. The pressure-regulating vial adapter of claim 15 , wherein, in the deflated state and with the housing coupled with the vial, a bottom of the reservoir is above a top of the vial.

22. The pressure-regulating vial adapter of claim 15 , wherein the piercing member comprises a regulating channel configured to convey the regulating fluid and an access channel configured to convey a medicinal liquid.

23. A pressure-regulating vial adapter comprising:

a housing configured to couple with a vial having a septum, the housing comprising a piercing member that is configured to be inserted through the septum of the vial in a distal direction, the piercing member having a distal tip;

a rigid enclosure comprising an internal space; and

a reservoir comprising a first flexible side made of a first sheet of material and a second flexible side made of a second sheet of material, the first and second sheets connected at a peripheral edge, the reservoir configured to inflate in the distal direction from a deflated state to an inflated state in response to regulating fluid being received between the first and second flexible sides;

wherein, in the deflated state and with the housing coupled with the vial, the entirety of the reservoir is positioned in the internal space of the rigid enclosure and outside of the vial; and

wherein, during inflation from the deflated state to the inflated state, a portion of the reservoir expands out of the rigid enclosure, such that some of the reservoir is in the rigid enclosure and some of the reservoir is not in the rigid enclosure.

24. The pressure-regulating vial adapter of claim 23 , wherein the first flexible side and the second flexible side are configured to unfold to increase the volume of the reservoir and to crumple to decrease the volume of the reservoir.

25. The pressure-regulating vial adapter of claim 23 , wherein, during inflation from the deflated state to the inflated state, a bottom end of the reservoir expands toward the vial.

26. The pressure-regulating vial adapter of claim 23 , wherein the reservoir is substantially centered with respect to an axial center of the pressure-regulating vial adaptor.

27. The pressure-regulating vial adapter of claim 23 , wherein, in the deflated state and with the housing coupled with the vial, a bottom of the reservoir is above a top of the vial.

28. The pressure-regulating vial adapter of claim 23 , wherein the piercing member comprises a regulating channel configured to convey the regulating fluid and an access channel configured to convey a medicinal liquid.

Assignments (1)
SECURITY INTEREST Recorded Oct 31, 2025
From: ICU MEDICAL, INC.; EXCELSIOR MEDICAL CORPORATION; TANGENT MEDICAL TECHNOLOGIES, INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 073428/0588 →
Continuity (10)
Continuation 18308500 · Apr 27, 2023
Continuation 17445705 · Aug 23, 2021
Continuation 16872754 · May 12, 2020
Continuation 15932248 · Feb 16, 2018
Continuation 14789806 · Jul 1, 2015
Continuation 14179475 · Feb 12, 2014
Continuation PCTUS2012051226 · Aug 16, 2012
Provisional Application 61614250 · Mar 22, 2012
Provisional Application 61525126 · Aug 18, 2011
Related Publication 20240156685A1 · May 16, 2024
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