IP Library Granted Patent US 12,521,553
Granted Patent B2
US 12,521,553 · App. 18/418,432 · Granted Jan 13, 2026

Systems and methods related to the treatment of back pain

Inventors: Amorn Wongsarnpigoon (Chapel Hill, NC); Maria E. Bennett (Beachwood, OH); Joseph W. Boggs (Carrboro, NC); John Chae (Strongsville, OH); Michael F. Saulino (Havertown, PA)
Assignee: SPR THERAPEUTICS, INC.
A61N1/36021A61N1/0558A61N1/36071
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,521,553
App. No.
18/418,432
Granted
Jan 13, 2026
Kind
B2
Abstract

The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least one muscle in a back of the animal body for pain relief.

Claims (45)

1 . A method comprising:

percutaneously inserting a lead comprising a single electrode within a patient;

delivering electrical stimulation to a medial branch of a dorsal ramus nerve that innervates a multifidus muscle of the patient; and

applying an intensity of electrical stimulation through the single electrode to activate motor axons of the multifidus muscle causing muscle contraction of the multifidus muscle without activation of painful sensory axons, which relieves back pain of the patient, wherein relief of the back pain results in functional improvement of the patient.

2 . The method of claim 1 , wherein the application of the intensity of electrical stimulation is performed by an external electrical stimulation device.

3 . The method of claim 1 , wherein the application of the intensity of electrical stimulation is performed by an implanted electrical stimulation device.

4 . The method of claim 1 , wherein the application of the intensity of electrical stimulation is performed by an electrical stimulation device and the electrical stimulation device is configured to apply a first set of electrical stimulation parameters.

5 . The method of claim 4 , wherein the electrical stimulation device is configured to apply a second set of electrical stimulation parameters, wherein the second set of electrical stimulation parameters are different from the first set of electrical stimulation parameters.

6 . The method of claim 5 , wherein the first and second set of electrical stimulation parameters are selected from a group consisting of:

frequency, pulse duration, amplitude, duty cycle, pattern of stimulus pulses, polarity, number of phases, and waveform shape.

7 . The method of claim 1 , further comprising:

applying a first set of electrical stimulation parameters;

comparing a second area of muscle activation caused by the electrical stimulation with an area of pain; and

applying a second set of electrical stimulation parameters.

8 . The method of claim 1 , further comprising:

inserting a second lead comprising an electrode;

applying a second electrical stimulation through the electrode; and

comparing a location of muscle activation caused by the second electrical stimulation with a location of pain.

9 . The method of claim 1 , further comprising:

turning on a channel of the single electrode;

applying electrical stimulation through the single electrode; and

comparing a location of muscle activation caused by the electrical stimulation with a location of pain.

10 . The method of claim 8 , further comprising:

turning off a channel of the single electrode;

applying an electrical stimulation through the single electrode; and

re-comparing a second location of muscle activation caused by the electrical stimulation with the location of pain.

11 . A method comprising:

percutaneously inserting a lead comprising an electrode within a patient;

delivering electrical stimulation to a medial branch of a dorsal ramus nerve that innervates a paraspinal muscle; and

applying an intensity of electrical stimulation through the electrode to activate motor axons of the paraspinal muscle causing muscle contraction of the paraspinal muscle without activation of painful sensory axons, which relieves back pain of the patient, wherein relief of the back pain results in functional improvement of the patient.

12 . The method of claim 11 , wherein the application of the intensity of electrical stimulation is performed by an external electrical stimulation device.

13 . The method of claim 11 , wherein the application of the intensity of electrical stimulation is performed by an implanted electrical stimulation device.

14 . The method of claim 11 , wherein the application of the intensity of electrical stimulation is performed by an electrical stimulation device and the electrical stimulation device is configured to apply a first set of electrical stimulation parameters.

15 . The method of claim 14 , wherein the lead comprises a second electrode.

16 . The method of claim 15 , wherein the electrical stimulation device is configured to apply a second set of electrical stimulation parameters through the second electrode, wherein the second set of electrical stimulation parameters are different from the first set of electrical stimulation parameters.

17 . The method of claim 16 , wherein the first and second set of electrical stimulation parameters are selected from a group consisting of:

frequency, pulse duration, amplitude, duty cycle, pattern of stimulus pulses, polarity, number of phases, and waveform shape.

18 . A method comprising:

percutaneously inserting a lead comprising an electrode within a patient;

delivering electrical stimulation via an external electrical stimulation device to a medial branch of a dorsal ramus nerve that innervates a paraspinal muscle; and

applying an intensity of electrical stimulation through the electrode to activate motor axons of the paraspinal muscle causing muscle contraction of the paraspinal muscle without activation of painful sensory axons which relieves back pain of the patient, wherein relief of the back pain results in functional improvement of the patient.

19 . The method of claim 18 , wherein the electrical stimulation comprises a pulse frequency of between 1 Hz to 100 Hz.

20 . The method of claim 19 , wherein the electrical stimulation comprises a cathodic amplitude of 0.1 mA to 40 mA.

21 . The method of claim 20 , wherein the electrical stimulation comprises a pulse duration of 1 μsec to 500 μsec.

22 . The method of claim 21 , wherein the pulse frequency, cathodic amplitude and pulse duration are adjustable.

Assignments (3)
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jan 30, 2024
From: SPR THERAPEUTICS, INC.
To: SLR INVESTMENT CORP., AS AGENT
Reel/Frame 066381/0075 →
SECURITY INTEREST Recorded Jan 30, 2024
From: SPR THERAPEUTICS, INC.
To: GEMINO HEALTHCARE FINANCE, LLC
Reel/Frame 066412/0400 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 22, 2024
From: WONGSARNPIGOON, AMORN; BENNETT, MARIA E.; BOGGS, JOSEPH W.; CHAE, JOHN; SAULINO, MICHAEL F.
To: SPR THERAPEUTICS, INC.
Reel/Frame 066193/0001 →
Continuity (4)
Continuation 16819301 · Mar 16, 2020
Continuation 13843002 · Mar 15, 2013
Provisional Application 61611560 · Mar 15, 2012
Related Publication 20240245910A1 · Jul 25, 2024
References Cited (38)
US 6671557B1 · Gliner · 2003 [cited by applicant]
US 6845271B2 · Fang et al. · 2005 [cited by applicant]
US 7337005B2 · Kim et al. · 2008 [cited by applicant]
US 7761166B2 · Giftakis et al. · 2010 [cited by applicant]
US 7792591B2 · Rooney et al. · 2010 [cited by applicant]
US 8249713B2 · Fang et al. · 2012 [cited by applicant]
US 8463383B2 · Sakai et al. · 2013 [cited by applicant]
US 8626302B2 · Bennett et al. · 2014 [cited by applicant]
US 8700177B2 · Strother et al. · 2014 [cited by applicant]
US 8954153B2 · Boggs · 2015 [cited by applicant]
US 10625075B2 · Wongsarnpigoon · 2020 [cited by examiner]
US 11878164B2 · Wongsarnpigoon · 2024 [cited by examiner]
US 20020077572A1 · Fang et al. · 2002 [cited by applicant]
US 20050240243A1 · Barolat et al. · 2005 [cited by applicant]
US 20060052826A1 · Kim et al. · 2006 [cited by applicant]
US 20070027501A1 · Jensen et al. · 2007 [cited by applicant]
US 20080188906A1 · Barolat et al. · 2008 [cited by applicant]
US 20080228241A1 · Sachs · 2008 [cited by applicant]
US 20080294229A1 · Friedman et al. · 2008 [cited by applicant]
US 20100036454A1 · Bennett et al. · 2010 [cited by applicant]
US 20100152808A1 · Boggs · 2010 [cited by applicant]
US 20100152809A1 · Boggs · 2010 [cited by applicant]
US 20100241195A1 · Meadows et al. · 2010 [cited by applicant]
US 20110021943A1 · Lacour et al. · 2011 [cited by applicant]
US 20110224665A1 · Crosby et al. · 2011 [cited by applicant]
US 20120016439A1 · Alataris et al. · 2012 [cited by applicant]
US 20120290055A1 · Boggs · 2012 [cited by applicant]
US 20120310301A1 · Bennett et al. · 2012 [cited by applicant]
US 20120310302A1 · Bennett et al. · 2012 [cited by applicant]
US 20120310314A1 · Bennett et al. · 2012 [cited by applicant]
US 20130096641A1 · Strother et al. · 2013 [cited by applicant]
US 20130197615A1 · Rundle et al. · 2013 [cited by applicant]
US 20130238066A1 · Boggs et al. · 2013 [cited by applicant]
US 20130296966A1 · Wongsarnpigoon et al. · 2013 [cited by applicant]
Examination Report No. 1 in AU2019236590, dated Oct. 10, 2020, 5 pages. [cited by applicant]
Extended European Search Report in EP13760774.3, mailed Jan. 5, 2016, 11 pages. [cited by applicant]
Extended Search Report in EP20210229.9, mailed Dec. 15, 2020, 11 pages. [cited by applicant]
International Search Report and Written Opinion in PCT/US2013/032627, mailed Jun. 4, 2013, 14 pages. [cited by applicant]