RAMAN SPECTROSCOPY METHOD FOR BLOOD GLUCOSE MEASUREMENT
Blood glucose level measurement includes a light source configured to irradiate light to a subject; a monochrome part configured to separate wavelength components of the light that is reflected and scattered from the subject; a light receiver configured to receive the light transmitted via the monochrome part and to generate electrical signals based on the received light; and a processor configured to extract information on the blood glucose level of the subject based on a frequency shift of the light due to the Raman effect.
1 . A method comprising:
irradiating light to a subject;
separating wavelength components of the light that is reflected and scattered from the subject;
generating electrical signals based on light, in which wavelength components are separated, wherein the electrical signals are representative of a Raman spectrum of the light that is reflected and scattered from the subject; and
analyzing the electrical signals to extract information on a glucose level of the subject based on the Raman spectrum,
wherein the glucose level in an interstitial fluid is measured based on ratios of areas of (a) a peak at about 1450 cm −1 , (b) a peak at about 1660 cm −1 , and (c) a peak at about 1125 cm −1 in the Raman spectrum.
2 . The method of claim 1 , wherein, for (a) the peak at about 1450 cm −1 , the area is obtained in a range between about 1415 cm −1 and about 1480 cm −1 , which corresponds to proteins.
3 . The method of claim 1 , wherein, for (b) the peak at about 1660 cm −1 , the area is obtained in a range between about 1630 cm −1 to about 1685 cm −1 , which corresponds to fats.
4 . The method of claim 1 , wherein, for (c) the peak at about 1125 cm −1 , the area is obtained by summing areas in three ranges (c-i) between about 1089 cm −1 and about 1160 cm −1 , (c-ii) between about 1115 cm −1 and about 1140 cm −1 , and (c-iii) between about 1120 cm −1 and about 1130 cm −1 , which correspond to glucose.
5 . The method of claim 1 , wherein the light is irradiated in a near-infrared (NIR) range or in a mid-infrared (MIR) range.
6 . The apparatus of claim 1 , wherein the electrical signals are generated using a charge coupled device (CCD).