System and method for assessing and monitoring the hemodynamic condition of a patient

1. A method for monitoring of a physiological condition of a patient, the method comprising:

at a computing system, receiving a physiological signal stream;

at the computing system, determining a set of labels associated with the physiological signal stream, comprising:

when a first low data quality criterion of a set of criteria is met by a portion of the physiological signal stream, assigning a first label to the portion of the physiological signal stream;

determining a set of features based on a set of waveforms of the physiological signal stream, wherein the set of features are not determined based on waveforms associated with the portion of the physiological signal stream associated with the first label;

determining a risk classification of the patient based on the set of features; and

in response to determining the risk classification, automatically initiating administration of a drug delivery to the patient at a therapeutic delivery system.

2. The method of claim 1 , wherein the set of features comprises a set of consolidated waveform peaks.

3. The method of claim 2 , wherein the set of consolidated waveform peaks correspond to hemodynamic instability and can comprise at least one of: P, Q, R, S peaks (ECG), peaks in a pulse oximeter signal, an arterial blood pressure (ABP) waveform, an intracranial waveform, or an electroencephalogram (EEG) signal waveform.

4. The method of claim 2 , wherein the set of consolidated waveform peaks are determined through a wavelet transform peak detection process.

5. The method of claim 2 , wherein the set of consolidated waveform peaks are determined through a taut string detection process.

6. The method of claim 1 , wherein the set of features comprise at least one of: a heart rate variability metric, or a morphology metric.

7. The method of claim 1 , further comprising, when no portion of the physiological signal stream meets a criterion of the set of criteria: assigning one of a second and third label to the physiological signal stream based on a set of physiological stability values.

8. The method of claim 1 , wherein the first low data quality criterion comprises a missing data criterion.

9. The method of claim 1 , wherein the first low data quality criterion comprises a noisy data criterion.

10. The method of claim 1 , wherein the set of features comprises a set of patient specific waveform features.

11. The method of claim 10 , wherein the patient specific waveform features comprise at least one of: a set of waveform outliers, a set of waveform shapes, or a set of waveform amplitudes.

12. The method of claim 10 , further comprising:

checking the physiological signal stream for a second low data quality criterion;

when the second low data quality criterion is met by a portion of the physiological signal stream, assigning a second label to the physiological signal stream.

13. A method for monitoring a physiological condition of a patient, the method comprising:

at a computing system, processing a physiological signal stream comprising a set of waveforms, wherein processing the physiological signal stream comprises:

checking the physiological signal stream for portions of the physiological signal stream that satisfy any of a set of criteria associated with data quality;

when the set of criteria are not satisfied:

determining a set of features based on the set of waveforms, wherein the set of features are not determined based on waveforms associated with the portions of the physiological signal stream that satisfy any of the set of criteria;

determining a set of physiological stability values based on the set of features;

determining a risk classification of the patient based on the set of physiological stability values; and

in response to determining the risk classification, automatically initiating administration of a therapeutic treatment to the patient at a therapeutic delivery system.

14. The method of claim 13 , further comprising determining a set of qualitative signal quality labels for the physiological signal stream, wherein when any of the set of data criteria are satisfied, a corresponding label of the set of qualitative signal quality labels indicates a low data quality of a portion of the physiological signal stream.

15. The method of claim 13 , wherein the therapeutic delivery system comprises a therapeutic delivery mechanism and a processor, wherein the processor is configured to control administration of the therapeutic treatment to the patient based on the risk classification.

16. The method of claim 13 , wherein the set of features are determined based on individual signals within the set of waveforms and averaged signals within the set of waveforms.

17. The method of claim 13 , wherein processing the physiological signal stream is performed for consecutive windows of data within the physiological signal stream, further comprising, if set of criteria are satisfied for a window, terminating processing of the window.

18. The method of claim 13 , further comprising, when at least one of the set of criteria is satisfied, assigning a low data quality label to the physiological signal stream.

19. The method of claim 13 , wherein the physiological signal stream comprises an electrocardiogram (ECG) signal stream.

20. The method of claim 13 , wherein the risk classification is associated with at least one of: a potential cardiac event, a predicted time until hemodynamic instability, or a patient deterioration event.