DEVICES AND METHODS FOR A VARIABLY LOCKING SYRINGE ASSEMBLY
The present invention disclosed exemplary variably lockable syringe assemblies, methods of making and using the same. Such syringe assemblies can be used in multiple medical, surgical, veterinary and research applications. A syringe assembly disclosed herein may dispense a dose of a composition one or more times by locking and unlocking the plunger.
1 . A syringe assembly comprising:
a) a barrel comprising a barrel key located within the barrel lumen at a proximal end of the barrel;
b) a plunger comprising at least one teeth section structure and at least one flat section structure;
wherein the plunger is lockable along the lumen of the barrel between the distal end of the lumen and the proximal end of the lumen by positioning the barrel key between two teeth or between a tooth and an edge; and
wherein the plunger is unlockable by moving a flat section of the plunger to face or be adjacent to the barrel key.
2 . The syringe assembly of claim 1 , wherein the teeth section structure comprises multiple teeth.
3 . The syringe assembly of claim 1 , wherein the teeth section structure comprises an edge structure.
4 . The syringe assembly of claim 1 , wherein the teeth section structure comprises multiple teeth and at least one edge structure.
5 . The syringe assembly of claim 1 , wherein the teeth section structure comprises multiple teeth and a proximal edge structure and a distal edge structure.
6 . The syringe assembly of claim 1 , wherein the plunger comprises two teeth section structures.
7 . The syringe assembly of claim 1 , wherein the barrel comprises indicia.
8 . The syringe assembly of claim 1 , wherein the barrel further comprises a distal inlet/outlet port.
9 . The syringe assembly of claim 8 , wherein an article is attached to the distal inlet/outlet port.
10 . The syringe assembly of claim 9 , wherein the article is a catheter, tubing, a needle or a medical device.
11 . A method of inflating a catheter balloon, comprising
a) attaching a syringe assembly comprising i) a barrel comprising a fluid composition, having a proximal end and a distal end, comprising a barrel key located within the barrel lumen at a proximal end of the barrel, and an inlet/outlet port at the distal end; and ii) a plunger comprising at least one teeth section structure and at least one flat section structure; wherein the plunger is lockable along the lumen of the barrel between the distal end of the lumen and the proximal end of the lumen by positioning the barrel key between two teeth or between a tooth and an edge; and wherein the plunger is unlockable by moving a flat section of the plunger to face or be adjacent to the barrel key; to a port in fluid connection with a balloon lumen;
b) moving the plunger in a distal direction within the barrel lumen to move at least a portion of the fluid through and out the inlet/outlet port and into a balloon lumen; and optionally,
c) locking the plunger at a desired position within the barrel lumen by rotating the plunger so that the barrel key is positioned between two teeth or between a tooth and an edge.
12 . The method of claim 11 , wherein the port in fluid connection with the balloon lumen is connected to a catheter comprising the balloon.
13 . The method of claim 11 , wherein the port in fluid connection with the balloon lumen is connected to a medical device.
14 . The method of claim 11 , further comprising deflating the balloon by unlocking the plunger wherein the plunger is rotated so that the flat section structure is facing the barrel key.
15 . The method of claim 14 , further comprising moving the plunger in a proximal direction to reduce the volume of the inflated balloon.
16 . The method of claim 11 , wherein the fluid is air or a liquid.
17 . The method of claim 11 , wherein the teeth section structure of the syringe assembly comprises multiple teeth and at least one edge structure.
18 . The method of claim 11 , wherein the teeth section structure of the syringe assembly comprises multiple teeth and a proximal edge structure and a distal edge structure.
19 . The method of claim 11 , wherein the plunger of the syringe assembly comprises two teeth section structures.
20 . A method for injecting a composition into a subject comprising, a) attaching a syringe assembly comprising i) a barrel containing a composition, having a proximal end and a distal end, and comprising a barrel key located within the barrel lumen at a proximal end of the barrel, and an inlet/outlet port at the distal end; and ii) a plunger comprising at least one teeth section structure and at least one flat section structure; wherein the plunger is lockable along the lumen of the barrel between the distal end of the lumen and the proximal end of the lumen by positioning the barrel key between two teeth or between a tooth and an edge; and wherein the plunger is unlockable by moving a flat section of the plunger to face or be adjacent to the barrel key; to a needle useful for injection;
a) inserting the needle into a subject at a target site;
b) moving the plunger a desired distance in a distal direction within the barrel lumen to move at least a portion of the composition through and out the inlet/outlet port, through the needle and into the target site to inject a desired amount of the composition;
c) locking the plunger at the desired distance position within the barrel lumen by rotating the plunger so that the barrel key is positioned between two teeth or between a tooth and an edge;
d) withdrawing the needle from the target site, and optionally, repeating steps a) to d) at a second target site.