Methods and devices for endovascular ablation of a splanchnic nerve
Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
1. A method of ablating a greater splanchnic nerve, comprising:
inserting a catheter into a vascular lumen of a subject;
guiding the catheter towards a location proximate to the greater splanchnic nerve at a location adjacent a T9, T10, or T11 vertebra while in one or both of an azygos vein or an intercostal vein;
piercing vascular tissue of the one or both of the azygos vein or the intercostal vein with a needle assembly extending outwards from the catheter, wherein the needle assembly comprises one or more electrodes; and
delivering energy to the greater splanchnic nerve with the one or more electrodes to ablate the greater splanchnic nerve when the catheter is in the location adjacent a T9, T10, or T11 vertebra while in the one or both of the azygos vein or the intercostal vein.
2. The method of claim 1 , further comprising:
delivering stimulation energy to the greater splanchnic nerve prior to piercing the vascular tissue of the subject; and
measuring a physiological response to the stimulation energy, thereby indicating whether the location of the catheter is in sufficient proximity to the greater splanchnic nerve.
3. The method of claim 1 , further comprising using a radiographic marker of the catheter to orient the catheter within the vascular lumen of the subject such that it is in a direction that aligns the needle assembly with the greater splanchnic nerve.
4. The method of claim 1 , further comprising,
delivering confirmatory stimulation energy following ablation of the greater splanchnic nerve; and
measuring a physiological response, or a change in physiological response, corresponding to the confirmatory stimulation energy, thereby confirming an interrupted nerve activity of the greater splanchnic nerve.
5. The method of claim 1 , wherein guiding the catheter towards the location proximate to the greater splanchnic nerve comprises guiding the catheter to the azygos vein.
6. The method of claim 1 , wherein guiding the catheter towards the location proximate to the greater splanchnic nerve comprises guiding the catheter to the intercostal vein.
7. A method of ablating a greater splanchnic nerve, comprising:
delivering an ablation catheter to one or both of an azygos vein or an intercostal vein at a location adjacent a T9, T10, or T11 vertebra;
deploying a telescoping needle assembly outward from an exit port of the ablation catheter and puncturing through the azygos vein or the intercostal vein with the telescoping needle assembly, the needle assembly comprising one or more electrodes; and
delivering energy from the one or more electrodes to ablate the greater splanchnic nerve when the ablation catheter is in the location adjacent a T9, T10, or T11 vertebra.
8. The method of claim 7 wherein the deploying step deploys the telescoping needle assembly into a straight configuration outside of the exit port.
9. The method of claim 7 , wherein the needle assembly comprise a first member with a sharped distal end, wherein puncturing through the azygos vein or the intercostal vein comprises puncturing through the azygos vein or the intercostal vein using the first member.
10. The method of claim 9 , wherein the needle assembly further comprises a second member in a telescoping relationship with the first member, wherein the deploying step comprises extending the second member outward from the first member, and wherein the one or more electrodes are carried by the second member.
11. The method of claim 7 , wherein the needle assembly comprise a first member and a second member with a sharped distal end, wherein puncturing through the azygos vein or the intercostal vein comprises puncturing through the azygos vein or the intercostal vein using the second member, and wherein the deploying step comprises extending the second member from within the first member.
12. The method of claim 7 , further comprising:
delivering stimulation energy to the greater splanchnic nerve prior to puncturing through the azygos vein or the intercostal vein; and
measuring a physiological response to the stimulation energy, thereby indicating whether a location of the one or more electrodes is in sufficient proximity to the greater splanchnic nerve.
13. The method of claim 7 , further comprising using a radiographic marker of the catheter to orient the ablation catheter within one or both of the azygos vein or the intercostal vein such that it is in a direction that aligns the needle assembly with the greater splanchnic nerve.
14. The method of claim 7 , further comprising,
delivering confirmatory stimulation energy following ablation of the greater splanchnic nerve; and
measuring a physiological response, or a change in physiological response, corresponding to the confirmatory stimulation energy, thereby confirming an interrupted nerve activity of the greater splanchnic nerve.
15. The method of claim 7 , wherein the delivering step comprises delivering the ablation catheter to the intercostal vein.
16. A method of ablating a greater splanchnic nerve, comprising:
delivering an ablation catheter to one or both of an azygos vein or an intercostal vein at a location adjacent a T9, T10, or T11 vertebra;
deploying a telescoping needle assembly outward from an exit port of the ablation catheter and puncturing through the azygos vein or the intercostal vein with the telescoping needle assembly, the telescoping needle assembly comprising first and second telescoping members, the deploying step causing the second member to extend from the first member, the second member carrying one or more electrodes thereon; and
delivering energy from the one or more electrodes to ablate the greater splanchnic nerve when the ablation catheter is in the location adjacent a T9, T10, or T11 vertebra.
17. The method of claim 16 , wherein the first member has a sharped distal end, and wherein the puncturing step comprises puncturing through the azygos vein or the intercostal vein using the first member.
18. The method of claim 16 , wherein the first member has a blunt distal end.
19. The method of claim 16 , wherein the deploying step deploys the first and second members in straight configurations outside of the exit port.
20. The method of claim 16 , further comprising:
delivering stimulation energy to the greater splanchnic nerve prior to puncturing through the azygos vein or the intercostal vein; and
measuring a physiological response to the stimulation energy, thereby indicating whether the ablation catheter location is in sufficient proximity to the greater splanchnic nerve to ablate the greater splanchnic nerve during the energy delivering step.
21. The method of claim 16 , further comprising using a radiographic marker of the catheter to orient the ablation catheter within one or both of the azygos vein or the intercostal vein such that it is in a direction that aligns the needle assembly with the greater splanchnic nerve.
22. The method of claim 16 , further comprising,
delivering confirmatory stimulation energy following ablation of the greater splanchnic nerve; and
measuring a physiological response, or a change in physiological response, corresponding to the confirmatory stimulation energy, thereby confirming an interrupted nerve activity of the greater splanchnic nerve.
23. The method of claim 16 , wherein the delivering step comprises delivering the ablation catheter to the intercostal vein.