Anti-BCMA antibody drug conjugate combination treatment for cancer
Disclosed herein is a method of treating cancer, such as multiple myeloma, involving the combination of an anti-BCMA antigen binding protein (e.g., an anti-BCMA antibody) and an immunomodulatory drug (e.g. pomalidomide or lenalidomide). The combinations can also include an anti-inflammatory compound (e.g. dexamethasone).
1. A method of treating relapsed/refractory multiple myeloma in a human subject that has been treated with at least one prior cancer treatment, the method comprising administering to the human subject:
1.9 mg/kg, 2.5 mg/kg, or 3.4 mg/kg of an anti-BCMA antibody-drug conjugate on day 1 of a 28-day cycle; wherein the anti-BCMA antibody drug conjugate comprises an antibody comprising the heavy chain amino acid sequence set forth in SEQ ID NO: 9 and the light chain amino acid sequence set forth in SEQ ID NO: 10, and wherein the antibody is conjugated to MMAF;
4 mg of pomalidomide on days 1-21 of the 28-day cycle; and 20 mg or 40 mg of dexamethasone on days 1, 8, 15, and 22 of the 28-day cycle.
2. The method of claim 1 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of the 28-day cycle.
3. The method of claim 1 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of the 28-day cycle.
4. The method of claim 1 , wherein the human subject has been treated with at least two prior cancer treatments.
5. The method of claim 4 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of the 28-day cycle.
6. The method of claim 4 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of the 28-day cycle.
7. A method of treating relapsed/refractory multiple myeloma in a human subject, the method comprising administering to the human subject:
1.9 mg/kg, 2.5 mg/kg, or 3.4 mg/kg of an anti-BCMA antibody-drug conjugate; wherein the anti-BCMA antibody drug conjugate comprises an antibody comprising a heavy chain variable region (VH) sequence as set forth in SEQ ID NO: 7 and a light chain variable region (VL) sequence as set forth in SEQ ID NO: 8, and wherein the antibody is conjugated to MMAF;
4 mg of pomalidomide; and
20 mg or 40 mg of dexamethasone.
8. The method of claim 7 , wherein the anti-BCMA antibody drug conjugate comprises an antibody comprising the heavy chain amino acid sequence set forth in SEQ ID NO: 9 and the light chain amino acid sequence set forth in SEQ ID NO: 10.
9. The method of claim 7 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject.
10. The method of claim 7 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject.
11. The method of claim 8 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject.
12. The method of claim 8 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject.
13. The method of claim 11 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of a 28-day cycle.
14. The method of claim 12 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of a 28-day cycle.
15. The method of claim 13 , wherein 4 mg of pomalidomide is administered to the human subject on days 1-21 of the 28-day cycle.
16. The method of claim 14 , wherein 4 mg of pomalidomide is administered to the human subject on days 1-21 of the 28-day cycle.
17. The method of claim 15 , wherein 20 mg or 40 mg of dexamethasone is administered to the human subject on days 1, 8, 15, and 22 of the 28-day cycle.
18. The method of claim 16 , wherein 20 mg or 40 mg of dexamethasone is administered to the human subject on days 1, 8, 15, and 22 of the 28-day cycle.
19. The method of claim 9 , wherein 1.9 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 of a 28-day cycle; 4 mg of pomalidomide is administered to the human subject on days 1-21 of the 28-day cycle; and 20 mg or 40 mg of dexamethasone is administered to the human subject on days 1, 8, 15, and 22 of the 28-day cycle.
20. The method of claim 10 , wherein 2.5 mg/kg of the anti-BCMA antibody-drug conjugate is administered to the human subject on day 1 a 28-day cycle: 4 mg of pomalidomide is administered to the human subject on days 1-21 of the 28-day cycle; and 20 mg or 40 mg of dexamethasone is administered to the human subject on days 1, 8, 15, and 22 of the 28-day cycle.