IP Library Granted Patent US 12,226,373
Granted Patent B2
US 12,226,373 · App. 18/458,727 · Granted Feb 18, 2025

Treatment of fragile X syndrome with cannabidiol

Inventors: Marcel Bonn-Miller (Lexington, NC); Nancy Tich (Saint Paul, MN); Donna Gutterman (Raleigh, NC); John Messenheimer (Moncure, NC); Terri Sebree (Gladwyne, PA)
Assignee: Harmony Biosciences Management, inc.
A61K31/05A61K9/0014A61K9/06A61K36/185A61P25/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,226,373
App. No.
18/458,727
Granted
Feb 18, 2025
Kind
B2
Abstract

The present technology relates to a method of treating one or more behavioral symptoms of Fragile X Syndrome in a subject by transdermally administering an effective amount of cannabidiol (CBD) to the subject wherein one or more behavioral symptoms of Fragile X Syndrome are treated in the subject.

Claims (8)

1. A method of reducing social avoidance behavior associated with a human suffering from Fragile X Syndrome comprising administering a therapeutically effective amount of synthetic cannabidiol to the human suffering from Fragile X Syndrome to effectively treat the Fragile X Syndrome in the human in need thereof.

2. The method of claim 1 , wherein the cannabidiol is (-)-cannabidiol.

3. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is 250 mg total daily.

4. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is 500 mg total daily.

5. The method of claim 1 , wherein the cannabidiol is formulated as a permeation-enhanced gel.

6. The method of claim 1 , wherein the cannabidiol is administered in a single-daily dose.

7. The method of claim 1 , wherein the cannabidiol is administered in two daily doses.

8. The method of claim 1 , wherein the therapeutically effective amount of cannabidiol is between about 50 mg to 500 mg total daily.

Assignments (3)
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded May 18, 2026
From: HARMONY BIOSCIENCES MANAGEMENT, INC. (F/K/A ZYNERBA PHARMACEUTICALS, INC.)
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 075642/0639 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2024
From: BONN-MILLER, MARCEL; TICH, NANCY; GUTTERMAN, DONNA; MESSENHEIMER, JOHN; SEBREE, TERRI B.
To: ZYNERBA PHARMACEUTICALS, INC.
Reel/Frame 068597/0362 →
CHANGE OF NAME Recorded Sep 16, 2024
From: ZYNERBA PHARMACEUTICALS, INC.
To: HARMONY BIOSCIENCES MANAGEMENT, INC.
Reel/Frame 068963/0047 →