Slit lamp microscope capable of imaging goblet cells
View Patent ↗A slit lamp microscope may include first and second arms rotatably provided on a main shaft; a microscope provided on the first arm and used to observe a subject's eyeball; a light source unit provided on the second arm and irradiating light including near-ultraviolet and visible light regions, including light with a wavelength of 405 nm, to the eyeball of a subject; a third arm rotatably provided on the main shaft; a camera provided on the main shaft and imaging the eyeball of the subject; an excitation filter that transmits only light with a wavelength of 405 nm that induces a fluorescence reaction in stained goblet cells among the light irradiated from the light source unit to the eyeball of the subject; and a light receiving filter that transmits only the light fluorescently reacted in the goblet cells among the light received by the camera.
1 . A slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells, comprising:
a stand placed on an installation surface;
a face holder placed over the stand and on which a subject's head rests;
a support base placed over the stand to be movable in a horizontal direction;
a main shaft placed over the support base and having a rotation axis in a vertical direction;
a first arm, a second arm, and a third arm, wherein each of the first arm, the second arm, and the third arm is independently and rotatably coupled to the main shaft in a coaxial arrangement about the rotation axis;
a microscope coupled to the first arm and used to observe a subject's eyeball;
a light source unit coupled to the second arm and configured to irradiate light including near-ultraviolet and visible light regions, including light with a wavelength of 405 nm, to the eyeball of a subject;
a camera coupled to the third arm and configured to capture an image of the eyeball of the subject;
the third arm comprising a mount head;
a filter boom portion extending from the mount head toward a front direction of the camera;
a filter post extending upward from the filter boom portion to a front side of the lens of the camera;
an excitation filter configured to transmit only light with a wavelength of 405 nm that induces a fluorescence reaction in stained conjunctival goblet cells among the light irradiated from the light source unit to the eyeball of the subject; and
a light receiving filter mounted on the filter post and configured to transmit only the light fluorescently reacted in the goblet cells.
2 . The slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells of claim 1 , further comprising a mount coupled to an end of the third arm, wherein the camera is detachably mounted on the mount.
3 . The slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells of claim 2 , wherein the mount head is configured to adjust an angle of the mount.
4 . The slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells of claim 1 , further comprising:
a light receiving filter mounting frame disposed at an end of the filter post and on which the light receiving filter is detachably mounted.
5 . The slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells of claim 1 , further comprising an excitation filter mounting portion coupled to the second arm,
wherein the light source unit is a white lamp, and
wherein the excitation filter is mounted on the excitation filter mounting portion and disposed over a light emission surface of the light source unit.
6 . The slit lamp microscope configured for capturing fluorescence images of conjunctival goblet cells of claim 1 ,
wherein the second arm is coupled to the main shaft higher than the first arm, and the third arm is coupled to the main shaft higher than the second arm.