USE OF DEXPRAMIPEXOLE FOR THE TREATMENT OF MODERATE TO SEVERE ASTHMA
Disclosed herein are methods of treating moderate to severe asthma of the eosinophilic phenotype in a human subject in need thereof with a daily dose of about 75 mg to about 300 mg of dexpramipexole or pharmaceutical acceptable salt thereof, and treating severe asthma of the eosinophilic phenotype in a human subject in need thereof with a daily dose of about 150 mg to about 300 mg of dexpramipexole or pharmaceutical acceptable salt thereof.
1 - 72 . (canceled)
73 . A method of improving forced vital capacity (FVC) in a human subject in need thereof comprising orally administering to the subject from about 75 mg to about 300 mg of dexpramipexole or a pharmaceutically acceptable salt thereof.
74 . The method of claim 73 , wherein the FVC is increased by about 2% to about 8% after administration.
75 . The method of claim 73 , wherein the FVC is increased by about 8% to about 12% after administration.
76 . The method of claim 73 , wherein the volume of FVC is increased by about 20 ml to about 200 ml after administration.
77 . The method of claim 73 , wherein the volume of FVC is increased by about 200 ml to about 450 ml after administration.
78 . The method of claim 73 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered once daily.
79 . The method of claim 73 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered twice per day.
80 . The method of claim 73 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 75 mg/day.
81 . The method of claim 73 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 150 mg/day.
82 . The method of claim 73 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 300 mg/day.
83 . The method of claim 80 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 37.5 mg twice per day.
84 . The method of claim 81 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 75 mg twice per day.
85 . The method of claim 82 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 150 mg twice per day.
86 . A method of reducing the amount of mucus plugs in the airways of a human subject in need thereof comprising orally administering to the subject from about 75 mg to about 300 mg of dexpramipexole or a pharmaceutically acceptable salt thereof.
87 . The method of claim 86 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered once daily.
88 . The method of claim 86 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered twice per day.
89 . The method of claim 86 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 75 mg/day.
90 . The method of claim 86 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 150 mg/day.
91 . The method of claim 86 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 300 mg/day.
92 . The method of claim 89 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 37.5 mg twice per day.
93 . The method of claim 90 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 75 mg twice per day.
94 . The method of claim 91 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 150 mg twice per day.
95 . A method of improving a score on St. George's Respiratory Questionnaire (SGRQ) in a human subject in need thereof comprising orally administering to the subject from about 75 mg to about 300 mg of dexpramipexole or a pharmaceutically acceptable salt thereof.
96 . The method of claim 95 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered once daily.
97 . The method of claim 95 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered twice per day.
98 . The method of claim 95 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 75 mg/day.
99 . The method of claim 95 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 150 mg/day.
100 . The method of claim 95 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a daily dose of about 300 mg/day.
101 . The method of claim 99 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 75 mg twice per day.
102 . The method of claim 100 , wherein dexpramipexole or a pharmaceutically acceptable salt thereof is administered at a dose of about 150 mg twice per day.