IP Library › Granted Patent US 12,357,599
Granted Patent B2
US 12,357,599 · App. 18/488,342 · Granted Jul 15, 2025

Prodrugs of treprostinil

Inventors: Hitesh Batra (Herndon, VA); Liang Guo (Vienna, VA); Patrick Poisson (Chapel Hill, NC); Sri Harsha Tummala (Owings Mills, MD); Elizabeth Ann Harris (Lagrangeville, NY)
Assignees: United Therapeutics Corporation; MannKind Corporation
A61K31/192A61K47/545
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Quick Facts
Patent No.
US 12,357,599
App. No.
18/488,342
Granted
Jul 15, 2025
Kind
B2
Abstract

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Claims (7)

1. A compound of (4a) or (4b):

wherein R 1 is a carboxylic acid protecting group, R 2 is H or a hydroxyl protecting group, R 3 is H or a hydroxyl protecting group, and R 5 is a polymeric carrier.

2. The compound of claim 1 , wherein R 1 is a silyl carboxylic acid protecting group or a substituted or unsubstituted benzyl carboxylic acid protecting group.

3. The compound of claim 1 , wherein R 1 is a silyl carboxylic acid protecting group selected from trimethylsilyl, triethylsilyl, tri-iso-propylsilyloxymethyl, triisopropyl silyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, and phenyldimethylsilyl.

4. The compound of claim 3 , wherein R 1 is trimethylsilyl.

5. The compound of claim 1 , wherein R 1 is a substituted or unsubstituted benzyl carboxylic acid protecting group.

6. The compound of claim 5 , wherein R 1 is a benzyl group.

Assignments (1)
PATENT SECURITY AGREEMENT Recorded Aug 12, 2025
From: MANNKIND CORPORATION
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 072444/0525 →