Neural stimulation for reduced artefact
A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.
1. An implantable device for delivering a neural stimulus, the device comprising:
an array of electrodes; and
a processor configured to:
cause a first electrode of the array to deliver a first stimulus component of the neural stimulus and a third electrode of the array to deliver a third stimulus component of the neural stimulus simultaneously with the first stimulus component, the first stimulus component and the third stimulus component being of a first polarity, and
cause a second electrode of the array in between the first electrode and the third electrode to deliver a second stimulus component of the neural stimulus simultaneously with the first stimulus component and the third stimulus component, the second stimulus component being of a second polarity opposite the first polarity,
wherein the first, second, and third stimulus components are charge balanced, and
wherein the first stimulus component delivers a first charge which is unequal to a third charge delivered by the third stimulus component, the second stimulus component delivers a second charge, and the first charge and the third charge are selected so as to give rise to reduced artefact.
2. The implantable device of claim 1 , further comprising:
measurement circuitry configured to obtain a recording of a response to the neural stimulus at at least one sense electrode of the array;
wherein the processor is further configured to detect a neural response in the recording with a vector detector; and
wherein the first charge and the third charge of the neural stimulus have values that cause an artefact vector produced by the vector detector to be non-parallel to an evoked neural response vector produced by the vector detector.
3. The implantable device of claim 2 , wherein the inequality between the first charge and the third charge causes the artefact vector to be substantially orthogonal to the evoked neural response vector.
4. The implantable device of claim 2 , wherein a correlation delay of the vector detector and a stimulus duty ratio of the first charge to the second charge of the neural stimulus have values which cause the artefact vector to be non-parallel to the evoked neural response vector.
5. The implantable device of claim 4 , wherein the processor is further configured to adaptively adjust the stimulus duty ratio and/or the correlation delay in order to seek out a zero at the at least one sense electrode in a contribution of artefact to the recording of the response.
6. The implantable device of claim 5 , wherein the adjusting comprises adjusting the correlation delay so as to desirably align the evoked neural response vector.
7. The implantable device of claim 4 , wherein the processor is further configured to adaptively adjust the stimulus duty ratio in order to seek out a zero at the sense electrode in a contribution of artefact to the recording of the response.
8. The implantable device of claim 1 , wherein the first charge is between 0.6 times the second charge and 0.9 times the second charge.
9. The implantable device of claim 8 , wherein the first charge is 0.75 times the second charge.
10. The implantable device of claim 1 , wherein the first stimulus component, second stimulus component and third stimulus component are delivered in a first stimulus phase of the neural stimulus, and wherein the processor is further configured to deliver a second stimulus phase of the neural stimulus after the first stimulus phase of the neural stimulus, by:
delivering a fourth stimulus component of the neural stimulus at the first electrode and a sixth stimulus component of the neural stimulus at the third electrode simultaneously with the fourth stimulus component, the fourth stimulus component and the sixth stimulus component being of the second polarity; and
delivering a fifth stimulus component of the neural stimulus simultaneously with the fourth stimulus component and the sixth stimulus component at the second electrode, the fifth stimulus component being of the first polarity.
11. The implantable device of claim 10 , wherein the processor is further configured to:
deliver a third stimulus phase of the neural stimulus after the second stimulus phase of the neural stimulus, by:
delivering a seventh stimulus component of the neural stimulus at the first electrode and a ninth stimulus component of the neural stimulus at the third electrode simultaneously with the seventh stimulus component, the seventh stimulus component and the ninth stimulus component being of the first polarity; and
delivering an eighth stimulus component of the neural stimulus simultaneously with the seventh stimulus component and the ninth stimulus component at the second electrode, the eighth stimulus component being of the second polarity.
12. A method of delivering a neural stimulus, the method comprising:
delivering a first stimulus component of the neural stimulus at a first electrode of an array of electrodes and a third stimulus component of the neural stimulus at a third electrode of the array simultaneously with the first stimulus component, the first stimulus component and the third stimulus component being of a first polarity; and
delivering a second stimulus component of the neural stimulus at a second electrode of the array in between the first electrode and the third electrode simultaneously with the first stimulus component and the third stimulus component, the second stimulus component being of a second polarity opposite the first polarity;
wherein the first, second, and third stimulus components are charge balanced; and
wherein the first stimulus component delivers a first charge which is unequal to a third charge delivered by the third stimulus component, the second stimulus component delivers a second charge, and the first charge and the third charge are selected so as to give rise to reduced artefact.
13. The method of claim 12 , further comprising:
obtaining a recording of a response to the neural stimulus at at least one sense electrode of the array; and
detecting a neural response in the recording with a vector detector,
wherein the first charge and the third charge of the neural stimulus have values that cause an artefact vector produced by the vector detector to be non-parallel to an evoked neural response vector produced by the vector detector.
14. The method of claim 13 , wherein the inequality between the first charge and the third charge causes the artefact vector to be substantially orthogonal to the evoked neural response vector.
15. The method of claim 13 , wherein a correlation delay of the vector detector and a stimulus duty ratio of the first charge to the second charge of the neural stimulus have values which cause the artefact vector to be non-parallel to the evoked neural response vector.
16. The method of claim 15 , further comprising adaptively adjusting the stimulus duty ratio and/or the correlation delay in order to seek out a zero at the at least one sense electrode in a contribution of artefact to the recording of the response.
17. The method of claim 16 , wherein the adjusting comprises adjusting the correlation delay so as to desirably align the evoked neural response vector.
18. The method of claim 15 , further comprising adaptively adjusting the stimulus duty ratio in order to seek out a zero at the sense electrode in a contribution of artefact to the recording of the neural response.
19. The method of claim 12 , wherein the first charge is between 0.6 times the second charge and 0 . 9 times the second charge.
20. The method of claim 19 , wherein the first charge is 0.75 times the second charge.
21. The method of claim 12 , wherein the first stimulus component, second stimulus component and third stimulus component are delivered in a first stimulus phase of the neural stimulus, the method further comprising:
delivering a second stimulus phase of the neural stimulus after the first stimulus phase of the neural stimulus, by:
delivering a fourth stimulus component of the neural stimulus at the first electrode and a sixth stimulus component of the neural stimulus at the third electrode simultaneously with the fourth stimulus component, the fourth stimulus component and the sixth stimulus component being of the second polarity; and
delivering a fifth stimulus component of the neural stimulus simultaneously with the fourth stimulus component and the sixth stimulus component at the second electrode, the fifth stimulus component being of the first polarity.
22. The method of claim 21 , further comprising:
delivering a third stimulus phase of the neural stimulus after the second stimulus phase of the neural stimulus, by:
delivering a seventh stimulus component of the neural stimulus at the first electrode and a ninth stimulus component of the neural stimulus at the third electrode simultaneously with the seventh stimulus component, the seventh stimulus component and the ninth stimulus component being of the first polarity; and
delivering an eighth stimulus component of the neural stimulus simultaneously with the seventh stimulus component and the ninth stimulus component at the second electrode, the eighth stimulus component being of the second polarity.
23. A non-transitory computer readable medium for delivering a neural stimulus, comprising instructions which, when executed by one or more processors, causes performance of the following:
delivering a first stimulus component of the neural stimulus at a first electrode of an array of electrodes and a third stimulus component of the neural stimulus at a third electrode of the array simultaneously with the first stimulus component, the first stimulus component and the third stimulus component being of a first polarity; and
delivering a second stimulus component of the neural stimulus at a second electrode of the array in between the first electrode and the third electrode simultaneously with the first stimulus component and the third stimulus component, the second stimulus component being of a second polarity opposite the first polarity,
wherein the first, second, and third stimulus components are charge balanced; and
wherein the first stimulus component delivers a first charge which is unequal to a third charge delivered by the third stimulus component, the second stimulus component delivers a second charge, and the first charge and the third charge are selected so as to give rise to reduced artefact.