Auto-injector
According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).
1. An auto-injector comprising:
a housing having a sidewall that extends to a closed distal end of the housing;
a syringe retainer defining an opening for a syringe, the syringe retainer configured to move relative to the housing from a distal position to a proximal position such that the syringe moves proximally relative to the housing when the syringe is in the syringe retainer;
a compression spring disposed within the housing such that a distal end of the compression spring is engaged to the closed distal end of the housing, the auto-injector configured such that when the compression spring is released the syringe retainer moves from the distal position to the proximal position;
a needle shroud configured to move relative to the housing from (i) a first position in which a proximal end of the needle shroud extends from a proximal end of the housing by a first distance to (ii) a second position in which the proximal end of the needle shroud extends from the proximal end of the housing by a second distance that is less than the first distance; and
a second member having (i) a first portion configured to extend into an opening of the sidewall of the housing, and (ii) a second portion that extends outward of the sidewall of the housing when the first portion extends into the opening of the sidewall of the housing,
wherein the auto-injector is configured such that the needle shroud moves from the first position to the second position before the syringe retainer moves from the distal position to the proximal position.
2. The auto-injector of claim 1 , comprising a plunger rod and a first member releasably engaged to the plunger rod, the plunger rod and the first member configured to move together relative to the housing and relative to one another.
3. The auto-injector of claim 2 , wherein the first member comprises a deflectable inward protrusion releasably engaged to an outward protrusion of the plunger rod.
4. The auto-injector of claim 3 , wherein axial movement between the first member and the plunger rod is coupled when the deflectable inward protrusion is engaged to the plunger rod.
5. The auto-injector of claim 3 , wherein axial movement between the first member and the plunger rod is allowed after the deflectable inward protrusion has deflected out of engagement with the outward protrusion of the plunger rod, the outward protrusion having an outer diameter that is larger than an inner diameter of a sidewall of the syringe, and the syringe comprising a stopper configured to be in slidable contact with the sidewall of the syringe.
6. The auto-injector of claim 2 , wherein the compression spring is disposed around a distal portion the first member.
7. The auto-injector of claim 6 , wherein a proximal end of the distal portion of the first member has a flange in which a proximal end of the compression spring is engaged.
8. The auto-injector of claim 7 , wherein the distal portion of the first member is cylindrical.
9. The auto-injector of claim 2 , wherein a distal end of the first member has a surface that is parallel to and axially offset from the closed distal end of the housing.
10. The auto-injector of claim 2 , wherein the compression spring is between the first member and the housing.
11. The auto-injector of claim 1 , wherein the syringe retainer is configured such that a proximal side of a distal flange of the syringe is axially spaced apart from a distal end of a sidewall of the syringe retainer when the syringe is in the syringe retainer, an inner diameter of the sidewall of the syringe retainer being substantially equal to an outer diameter of a sidewall of the syringe.
12. The auto-injector of claim 1 , wherein the syringe retainer is configured such that a proximal portion of the syringe engages an inwardly angled protrusion located at a proximal end of the syringe retainer to limit proximal movement of the syringe relative to the syringe retainer when the syringe is in the syringe retainer.
13. The auto-injector of claim 1 , wherein the auto-injector comprises the syringe and is configured to dispense a medicament from the syringe.
14. The auto-injector of claim 1 , wherein the needle shroud is configured to move to a third position in which the proximal end of the needle shroud extends from the proximal end of the housing by a third distance that is greater than the first distance and the second distance.
15. The auto-injector of claim 14 , wherein movement of the needle shroud into the second position is limited when the needle shroud is in the third position.
16. The auto-injector of claim 15 , wherein the movement of the needle shroud into the second position is limited when the needle shroud is in the third position by an outward protrusion of the needle shroud.
17. The auto-injector of claim 16 , wherein the auto-injector is configured such that the outward protrusion of the needle shroud engages and slides proximally beyond a surface of the auto-injector when the needle shroud moves from the second position to the third position.
18. The auto-injector of claim 1 , wherein the auto-injector is configured to limit proximal movement of a plunger rod of the auto-injector when the first portion of the second member extends into the opening of the sidewall of the housing.
19. The auto-injector of claim 18 , wherein the second member is configured to be moved by a user from an inward position in which the first portion extends into the opening of the sidewall of the housing and an outward position in which the first portion has moved outward relative to the inward position.
20. An auto-injector comprising:
a housing having a sidewall that extends to a closed distal end of the housing;
a syringe retainer defining an opening for a syringe, the syringe retainer configured to move relative to the housing from a distal position to a proximal position during a first portion of an injection sequence;
a compression spring disposed within the housing such that a distal end of the compression spring is engaged to the closed distal end of the housing, the auto-injector configured such that when the compression spring is released the syringe retainer moves from the distal position to the proximal position;
a plunger rod configured to displace a stopper of the syringe to dispense a medicament of the syringe during a second portion of the injection sequence;
a needle shroud configured to move relative to the housing from (i) a first position in which a proximal end of the needle shroud extends from a proximal end of the housing by a first distance to (ii) a second position in which the proximal end of the needle shroud extends from the proximal end of the housing by a second distance that is less than the first distance; and
a second member having (i) a first portion configured to extend into an opening of the sidewall of the housing, and (ii) a second portion that extends outward of the sidewall of the housing when the first portion extends into the opening of the sidewall of the housing,
wherein the auto-injector is configured such that the needle shroud moves from the first position to the second position before the syringe retainer moves from the distal position to the proximal position.
21. The auto-injector of claim 20 , wherein the plunger rod comprises an outward protrusion for pushing the plunger rod in a proximal direction relative to the housing during the second portion of the injection sequence, the outward protrusion having an outer diameter that is larger than an inner diameter of a sidewall of the syringe, and the stopper is configured to be in slidable contact with the sidewall of the syringe.
22. The auto-injector of claim 20 , comprising a first member releasably engaged to the plunger rod and configured to move axially relative to the housing.
23. The auto-injector of claim 22 , wherein the first member comprises a deflectable inward protrusion releasably engaged to an outward protrusion of the plunger rod.
24. The auto-injector of claim 23 , wherein (i) axial movement between the first member and the plunger rod is coupled when the deflectable inward protrusion is engaged to the plunger rod and (ii) axial movement between the first member and the plunger rod is allowed after the deflectable inward protrusion has deflected out of engagement with the outward protrusion of the plunger rod.
25. The auto-injector of claim 22 , wherein the compression spring is disposed around a cylindrical distal portion the first member.
26. The auto-injector of claim 25 , wherein a proximal end of the cylindrical distal portion of the first member has a flange that extends outward of the cylindrical distal portion, a proximal end of the compression spring being engaged to the flange.
27. The auto-injector of claim 22 , wherein a distal end of the first member has surface that is parallel to and axially offset from the closed distal end of the housing.
28. The auto-injector of claim 22 , wherein the compression spring is between the first member and the housing.
29. The auto-injector of claim 20 , wherein the syringe retainer is configured such that a proximal side of a distal flange of the syringe is axially spaced apart from a sidewall of the syringe retainer when the syringe is in the syringe retainer.
30. The auto-injector of claim 29 , wherein the syringe retainer is configured such that a proximal portion of the syringe engages an inwardly angled protrusion located at a proximal end of the syringe retainer to limit proximal movement of the syringe relative to the syringe retainer when the syringe is in the syringe retainer.