High-Potency Vitamin C Topical Formulations
Topical formulations of L-ascorbic acid dissolved in a combination of a urea agent and a non-aqueous skin-compatible solvent are provided. The formulations are storage stable for an extended period of time without significant degradation of the L-ascorbic acid in the composition, are have desirable physical properties. The topical formulations can include high concentrations of the L-ascorbic acid. Topical compositions of this disclosure find use in treating or preventing a variety of cosmetic and/or dermatological conditions as well as to reduce the appearance of chronological and/or environmentally-caused skin aging.
1 . A storage stable topical composition comprising:
a. 5% to 28% by weight ascorbic acid;
b. 5% to 20% by weight of a urea agent; and
c. less than 10% by weight in total of one or more optional additional components;
d dissolved in a non-aqueous skin-compatible solvent comprising polyol, C (1-6) alkanediol, glycol ether, dimethyl ether, or a combination thereof; wherein the ascorbic acid is dissolved at a concentration (AA) that is above its maximum concentration in the solvent alone (X), and the urea is dissolved at a concentration that is at least (AA-X)*1.25.
2 . (canceled)
3 . (canceled)
4 . The composition of claim 1 , wherein the composition demonstrates less than 100 mol % degradation of the ascorbic acid after storage for 12 months at 25° C.±2° C. in a multi-use container.
5 . The composition of claim 1 , wherein the urea agent is urea, hydroxyethyl urea, or a mixture of urea and hydroxyethyl urea.
6 . The composition of claim 1 , wherein the urea agent is hydroxyethyl urea or a mixture of urea and hydroxyethyl urea.
7 . (canceled)
8 . The composition of claim 1 , wherein the solvent is selected from 1,3 propanediol, 1,2 propanediol, 1,3 butanediol, 1,5 pentanediol, 1,2 hexanediol, 1,6 hexanediol, glycerol, diglycerol, ethoxydiglycol, dimethyl isosorbide, and a mixture of 1,3 propanediol and 1,2 hexanediol.
9 . (canceled)
10 . (canceled)
11 . The composition of claim 1 , wherein the one or more optional additional components are selected from tocopherols, tocotrienols, ferulic acid, azelaic acid, hydroxy acids, panthenol, pinus pinaster bark extract, emulsifying agent, hyaluronic acid complex, madecassoside, acetyl zingerone, bakuchiol, and bis-ethylhexylhydroxydimethoxybenzylmalonate.
12 . (canceled)
13 . The composition of claim 1 , wherein the composition comprises about 10% to about 20% by weight of ascorbic acid.
14 . (canceled)
15 . (canceled)
16 . (canceled)
17 . The composition of claim 1 , wherein the composition comprises about 25% by weight of ascorbic acid.
18 . The composition of claim 1 , wherein the ratio of ascorbic acid to urea agent is:
a. 1.8 to 2.2;
b. 2 to 1;
c. 1.0 to 1.3;
d. 1.25 to 1; or
e. 1 to 1.
19 . (canceled)
20 . The composition of claim 13 , wherein the optional additional component comprises acetyl zingerone.
21 . (canceled)
22 . (canceled)
23 . (canceled)
24 . The composition of claim 13 , wherein the optional additional component comprises ferulic acid.
25 . (canceled)
26 . (canceled)
27 . (canceled)
28 . (canceled)
29 . The composition of claim 11 , wherein the optional additional component comprises 3% to 10% by weight of azelaic acid.
30 . (canceled)
31 . (canceled)
32 . (canceled)
33 . The composition of claim 1 , wherein the one or more optional additional components comprises 2% or less by weight of pinus pinaster bark extract.
34 . (canceled)
35 . (canceled)
36 . The composition of claim 1 , wherein the one or more optional additional components comprises madecassoside.
37 . (canceled)
38 . (canceled)
39 . The composition of claim 11 , wherein the optional additional component comprises a hydroxy acid selected from glycolic acid, lactic acid, mandelic acid, salicylic acid, capryloyl salicylic acid, salicyloyl phytosphingosine, gluconolactone, lactobionic acid, maltobionic acid, and combinations thereof.
40 . (canceled)
41 . (canceled)
42 . The composition of claim 39 , wherein the composition comprises 3% or less by weight of the hydroxy acid.
43 . (canceled)
44 . (canceled)
45 . (canceled)
46 . The composition of claim 45 , wherein the optional additional component comprises 10% or less by weight of panthenol.
47 . (canceled)
48 . (canceled)
49 . (canceled)
50 . (canceled)
51 . (canceled)
52 . An emulsion composition, comprising:
the composition according to claim 1 ;
an oil component; and
an optional emulsifying agent.
53 . The emulsion composition of claim 52 , wherein the oil component is silicone-based.
54 . The emulsion composition of claim 52 , wherein the emulsion composition comprises an emulsifying agent selected from polysorbates, laureth-4, potassium cetyl sulfate and silicone and silicone-elastomer-based emulsifiers and emulsifying blends.
55 . (canceled)
56 . (canceled)
57 . (canceled)
58 . (canceled)
59 . (canceled)
60 . (canceled)
61 . (canceled)
62 . (canceled)
63 . (canceled)
64 . (canceled)
65 . (canceled)
66 . (canceled)
67 . (canceled)
68 . (canceled)
69 . (canceled)