Granted Patent B2

US 12,310,914 · App. 18/502,131 · Granted May 27, 2025

Inventors: Meredith McGee (Cary, NC); Nathan Crosby (Cleveland, OH); John Chae (Strongsville, OH); Joseph W. Boggs (Chapel Hill, NC)

Assignee: SPR THERAPEUTICS, INC.

A61H23/006A61H23/004A61H39/08A61H2203/03

Abstract

Claims (24)

1. A method comprising:

percutaneously implanting a flexible, open-coiled helical lead in a tissue of a body;

permitting fibrotic ingrowth or encapsulation of the flexible, open-coiled helical lead to the body to permit connection of the flexible, open-coiled helical lead to a neural receptor;

after fibrotic ingrowth or encapsulation, allowing transference of energy from movement of the flexible, open-coiled helical lead relative to the tissue without electrical stimulation; and

causing mechanical generation of an action potential in at least one of Type Ia and Type Ib target afferent nerve fibers while avoiding generation of action potentials in non-target Type III and IV nerve fibers, wherein the at least one of Type Ia and Type Ib target afferent nerve fibers are located outside a central nervous system of the body.

2. The method according to claim 1 , wherein the at least one of Type Ia and Type Ib target afferent nerve fibers are located between the neural receptor and the central nervous system.

3. The method according to claim 1 , wherein the at least one of Type Ia and Type Ib target afferent nerve fibers innervate the neural receptor.

4. The method according to claim 1 , wherein the neural receptor is a proprioceptor.

5. The method according to claim 1 , wherein the at least one of Type Ia and Type Ib target afferent nerve fibers are in neural communication with the neural receptor and are activated at a location that is between the neural receptor and the central nervous system.

6. The method according to claim 5 , wherein the neural receptor is a proprioceptor.

7. The method according to claim 1 , wherein the non-target Type III and Type IV nerve fibers include efferent nerve fibers.

8. The method according to claim 1 , wherein the at least one of Type Ia and Type Ib target afferent nerve fibers are located outside the neural receptor.

9. A method comprising:

percutaneously implanting a flexible, open-coiled helical lead in a tissue of a body;

allowing mechanical connection of the flexible, open-coiled helical lead to a neural receptor in the tissue of the body; and

after mechanical connection of the flexible, open-coiled helical lead, mechanically generating an action potential in at least one of Type Ia and Type Ib target afferent nerve fibers located between the neural receptor and a central nervous system and, innervate a proprioceptor, while avoiding generation of action potentials in non-target efferent nerve fibers, wherein the at least one of Type Ia and Type Ib target afferent nerve fibers are located outside the central nervous system of the body, and wherein mechanically generating the action potential occurs through the flexible, open-coiled helical lead transferring energy from movement of the flexible, open-coiled helical lead relative to the tissue and without electrical stimulation to reduce a perception of pain.

10. The method according to claim 9 , wherein mechanically generating the action potential comprises stretching of the tissue and activation of nerve endings or the proprioceptor connected to afferent fibers proximate to the tissue.

11. A method of relieving pain comprising:

positioning a stimulation device having an open coil, helical lead in a human tissue proximate to neural receptors of target Type I afferent nerve fibers;

allowing mechanical connection of the open coil, helical lead to a tissue connected to a neural receptor;

allowing transfer of energy from movement of the stimulation device relative to the human tissue, generating an action potential in the target Type I afferent nerve fibers; and

wherein generating the action potential does not require electrical stimulation and does not generate action potentials in non-target Type III and/or Type IV afferent nerve fibers.

12. The method of claim 11 , wherein the mechanical connection of the stimulation device to the tissue connected to the neural receptor comprises allowing fibrotic ingrowth and/or encapsulation of the open coil, helical lead with the human tissue.

13. The method of claim 12 , wherein a proximal section of the open coil, helical lead is positioned outside of the human tissue and is covered by a bandage.

Assignments (3)

Continuity (4)

References Cited (319)