Treatment Regimen
The present invention relates to a novel treatment method for the treatment of an infection caused by Neisseria gonorrhoeae , comprising administering gepotidacin or a pharmaceutically acceptable salt thereof to a human in need thereof, in accordance with a treatment regimen as defined herein.
1 . A method for treating an infection caused by Neisseria gonorrhoeae in a human in need thereof, comprising administering gepotidacin or a pharmaceutically acceptable salt thereof to said human, wherein the gepotidacin or a pharmaceutically acceptable salt thereof is administered in two doses of 3 g each within one day.
2 . A method as claimed in claim 1 , wherein the gepotidacin or a pharmaceutically acceptable salt thereof is administered at an interval of 6-12 hours.
3 . A method as claimed in claim 1 , wherein the gepotidacin or a pharmaceutically acceptable salt thereof is administered at an interval of 10-12 hours.
4 . A method as claimed in claim 1 , wherein the gepotidacin is gepotidacin free base.
5 . A method as claimed in claim 1 , wherein the gepotidacin is gepotidacin methanesulphonate.
6 . A method as claimed in claim 1 , wherein the human is aged 12, 13, 14, 15, 16 or 17 years old.
7 . A method as claimed in claim 1 , wherein the human is aged 18 years or above.
8 . A method as claimed in claim 1 , wherein the human is male.
9 . A method as claimed in claim 1 , wherein the human is female.
10 . A method as claimed in claim 1 , wherein the infection caused by Neisseria gonorrhoeae is a urogenital infection.
11 . A method as claimed in claim 10 , wherein the infection caused by Neisseria gonorrhoeae is a urethral or cervical infection.
12 . A method as claimed in claim 11 , wherein the urogenital infection caused by Neisseria gonorrhoeae is an uncomplicated urethral or cervical infection.
13 . A method as claimed in claim 1 , wherein the infection caused by Neisseria gonorrhoeae is a rectal infection.
14 . A method as claimed in claim 1 , wherein the infection caused by Neisseria gonorrhoeae is a pharyngeal infection.
15 . A method as claimed in claim 1 , wherein the human has failed at least one prior line of treatment of the infection.
16 . A method as claimed in claim 1 , wherein an isolate of the Neisseria gonorrhoeae is resistant to an antibacterial agent selected from the group consisting of: ciprofloxacin, azithromycin, tetracycline, penicillin, ceftriaxone, cefixime, gentamicin and spectinomycin.
17 . A method as claimed in claim 1 , wherein the gepotidacin or a pharmaceutically acceptable salt thereof is administered orally.