COMPOSITION OF TANNIC ACID AND VITAMIN D AND METHODS OF USE
Compositions, kits, and methods that can be used to improve elastin concentration are described herein. For example, pharmaceutical compositions described herein comprise a therapeutically effective amount of a first agent and a therapeutically effective amount of a second agent, wherein the first agent is tannic acid, ellagic acid, or combinations thereof, and the second agent is vitamin D, hyaluronic acid, ferulic acid, or combinations thereof.
1 . A topical composition comprising:
a) a first agent that blocks elastin production; and
b) a second agent that promotes elastin production,
wherein the second agent neutralizes blocking of elastin production by the first agent.
2 . (canceled)
3 . The composition of claim 1 , wherein the first agent is a moisturizing agent selected from the group consisting of hyaluronic acid and its pharmaceutically acceptable salts, ferulic acid, and a vitamin D compound.
4 . The composition of claim 3 , wherein the moisturizing agent is at least two moisturizing agents selected from the group consisting of hyaluronic acid and its pharmaceutically acceptable salts, ferulic acid, and a vitamin D compound.
5 - 8 . (canceled)
9 . The composition of claim 3 , wherein the vitamin D compound is vitamin D3.
10 . (canceled)
11 . The composition of claim 1 , wherein the second agent is a polyphenol selected from the group consisting of tannic acid and ellagic acid.
12 . (canceled)
13 . The composition of claim 3 , wherein the second agent is a polyphenol selected from the group consisting of ellagic acid and tannic acid.
14 - 33 . (canceled)
34 . The composition of claim 1 , further comprising an elastin-derived peptide selected from the group consisting of IGVAPG (SEQ ID NO: 1), VGVAPG (SEQ ID NO: 2), and VGVTAG (SEQ ID NO: 3).
35 . The composition of claim 3 , wherein the elastin-derived peptide is selected from the group consisting of IGVAPG (SEQ ID NO: 1), VGVAPG (SEQ ID NO: 2), and VGVTAG (SEQ ID NO: 3).
36 . The composition of claim 11 , wherein the elastin-derived peptide is selected from the group consisting of IGVAPG (SEQ ID NO: 1), VGVAPG (SEQ ID NO: 2) and VGVTAG (SEQ ID NO: 3).
37 . The composition of claim 13 , wherein the elastin-derived peptide is selected from the group consisting of IGVAPG (SEQ ID NO: 1), VGVAPG (SEQ ID NO: 2), VGVTAG (SEQ ID NO: 3).
38 - 41 . (canceled)
42 . A method of enhancing elastin formation comprising the step of: administering to a subject in need thereof a therapeutically-effective amount of a topical composition according to claim 1 .
43 . (canceled)
44 . The method of claim 42 , wherein the first agent is a moisturizing agent selected from the group consisting of hyaluronic acid and its pharmaceutically acceptable salts, ferulic acid, and a vitamin D compound.
45 - 49 . (canceled)
50 . The method of claim 44 , wherein the vitamin D is vitamin D3.
51 . (canceled)
52 . The method of claim 44 , wherein second agent is a polyphenol selected from the group consisting of ellagic acid and tannic acid.
53 - 83 . (canceled)
84 . The method of claim 44 , wherein administering the topical composition according to claim 1 enhances collagen formation by at least 25% as compared to a control.
85 - 89 . (canceled)