SYSTEMS AND METHODS FOR DETECTING A HEALTH CONDITION
Embodiments herein include a method for detecting a health condition of a subject. The method can include obtaining a biological sample from the subject and placing it into a container having a headspace surrounding the biological sample. The method can include contacting a gas from the headspace with a chemical sensor element, the chemical sensor element including one or more discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set. Other embodiments are also included herein.
1 . A method for detecting a health condition of a subject, comprising:
obtaining a biological sample from the subject and placing it into a container having a headspace surrounding the biological sample;
contacting a gas from the headspace with a chemical sensor element, the chemical sensor element comprising one or more graphene components; and
sensing and storing capacitance data of the graphene components reflecting a range of bias voltages to obtain a sample data set.
2 . The method of claim 1 , classifying the sample data set into one or more preestablished classifications.
3 . The method of claim 1 , further comprising identifying a therapy to treat the subject based on the preestablished classification.
4 . The method of claim 1 , wherein the headspace above or around the biological sample includes a volume of a gas.
5 . The method of claim 1 , wherein the container is flushed with an inert gas prior to placing the biological sample into the container.
6 . The method of claim 1 , the container comprising a sample port, wherein the biological sample is placed into the container through the sample port.
7 . The method of claim 1 , wherein the gas from the head space is continuously drawn from the container and contacted with the chemical sensor element.
8 . The method of claim 1 , wherein the biological sample is incubated in the container for a period of time before the gas from the headspace is contacted with a chemical sensor element.
9 . The method of claim 1 , wherein the biological sample is heated to a temperature in the range of 25 degrees C. to 40 degrees C. prior to contacting the headspace with a chemical sensor element.
10 . The method of claim 1 , wherein obtaining a biological sample comprises obtaining one or more of an organ biopsy, blood, urine, bile, sweat, feces, lymph, cerebrospinal fluid, amniotic fluid, pericardial fluid, peritoneal fluid, saliva, synovial fluid, serous fluid, sebum, bone biopsy, muscle biopsy, cheek swab biopsy, or isolated cells.
11 . The method of claim 1 , wherein volatile organic compounds (VOCs) from the biological sample that are present in the gas from the headspace interface with the graphene components to influence sensed capacitance.
12 . The method of claim 1 , wherein sensing and storing capacitance of the graphene components graphene to obtain a sample data set is performed across a range of bias voltages, wherein the range of bias voltages is from −3 V to 3 V.
13 . The method of claim 1 , further storing additional data regarding the subject beyond sensed capacitance as part of the sample data set that is classified, the additional data comprising at least one of:
prior disease states of the subject;
age of the subject;
results of a physical examination;
symptoms experienced by the subject; and
data regarding specific biomarkers of one or more disease states.
14 . A container for detecting a disease state comprising:
a housing adapted to contain a biological sample of a subject, the housing defining a headspace comprising a volume of a gas; and
a chemical sensor element in fluid communication with the headspace, the chemical sensor element comprising one or more graphene components.
15 . The container of claim 14 , further comprising a gas inlet conduit and a gas outlet conduit, the gas outlet conduit configured to be in fluid communication with the chemical sensor element.
16 . The container of claim 14 , further comprising
a chemical sensor chamber, wherein the chemical sensor element is disposed in the chemical sensor chamber; and
a movable sealing member that can move between a first position and a second position;
wherein the chemical sensor element is in selective fluid communication with the headspace;
wherein movement between the first position and the second position exposes the chemical sensor chamber to fluid communication with the headspace.
17 . The container of claim 16 , wherein the movable sealing member is a plunger.
18 . The container of claim 14 , wherein the volume of the gas in the headspace comprises 0.5% to 50% of a total volume of the container.
19 . The container of claim 14 , further comprising a partition that is configured to be opened or closed during use.
20 . A method of treating a subject for a disease state comprising:
obtaining a biological sample from the subject and placing it into a container having a headspace above or around the biological sample;
contacting a gas from the headspace with a chemical sensor element, the chemical sensor element comprising one or more graphene components;
sensing and storing capacitance data of the graphene components reflecting a range of bias voltages to obtain a sample data set,
classifying the sample data set into one or more preestablished disease state classifications, and
identifying a therapy to treat the subject based on the disease state classification.