IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.
1 .- 20 . (canceled)
21 . A method of treating a disease state in a patient in need thereof, comprising administering to said patient a composition comprising a human monoclonal antibody that specifically binds IL-17 Receptor A, or an IL-17 Receptor A binding fragment thereof, and inhibits IL-17A from binding and activating said receptor, which antibody comprises a light chain CDR1, CDR2, and CDR3 amino acid sequence of SEQ ID NO:224, SEQ ID NO:225, and SEQ ID NO:226, respectively, and a heavy chain CDR1, CDR2, and CDR3 amino acid sequence of SEQ ID NO:146 SEQ ID NO:147 and SEQ ID NO:148, respectively, and a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative, or adjuvant.
22 . The method of claim 21 , wherein the antibody comprises a light chain variable domain amino acid sequence of SEQ ID NO: 40 and a heavy chain variable domain amino acid sequence of SEQ ID NO: 14.
23 . The method of claim 21 , wherein the disease state is selected from the group consisting of psoriasis, plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, and erythrodermic psoriasis.