IP Library › Granted Patent US 12,254,627
Granted Patent B2
US 12,254,627 · App. 18/541,153 · Granted Mar 18, 2025

Image analysis

Inventor: Yijun Huang (Fitchburg, WI)
Assignee: MERIT CRO, Inc.
G06T7/0012A61B3/1005A61B3/102A61B3/14A61B5/0035A61B5/0037A61B5/0066A61B5/14555A61B5/7246A61B8/085G01B9/0203G01B9/02091G01B11/00G06T7/30G06T7/62A61B2090/364A61B2090/3735A61F2009/00851A61N5/1017G06T2207/10101G06T2207/20104G06T2207/30041G06T2207/30096G06T2211/456
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Quick Facts
Patent No.
US 12,254,627
App. No.
18/541,153
Granted
Mar 18, 2025
Kind
B2
Abstract

Provided herein is technology relating to analysis of images and particularly, but not exclusively, to methods and systems for determining the area and/or volume of a region of interest using optical coherence tomography data. Some embodiments provide for determining the area and/or volume of a lesion in retinal tissue using three-dimensional optical coherence tomography data and a two-dimensional optical coherence tomography fundus image.

Claims (32)

1. A method for determining the area and/or volume of a lesion in the eye of a patient using optical coherence tomography (OCT), the method comprising:

scanning the eye of the patient with an OCT apparatus to acquire three-dimensional OCT data comprising at least a first segment and a second segment comprising the region of interest;

acquiring two-dimensional image data comprising the region of interest;

providing a boundary around the region of interest in the two-dimensional image data, the boundary enclosing an area A;

calculating the volume v within the boundary and between the first segment and the second segment;

calculating the average thickness t between the first segment and the second segment along the boundary;

calculating the volume of the region of interest V=v−(t×A); and

via a computer processor correlating the two-dimensional and three-dimensional data to quantify the lesion in the eye of the patient.

2. The method of claim 1 wherein the boundary is a circle, ellipse, polygon, or irregular shape.

3. The method of claim 1 further comprising determining a greatest linear distance across the region of interest in the two-dimensional image data.

4. The method of claim 1 wherein the boundary is a continuous boundary or a discontinuous boundary comprising one or more points, dots, straight line segments, or curved line segments marking the edges of the region of interest.

5. The method of claim 1 wherein the three-dimensional OCT data is a three-dimensional OCT image.

6. The method of claim 1 wherein the two-dimensional image data is OCT fundus data, a two-dimensional image produced by integrating three-dimensional OCT data, a cross-sectional slice of three-dimensional OCT data, or a photograph.

7. The method of claim 1 wherein the area A is calculated by interpolating between a plurality of points indicating the boundary of the region of interest.

8. The method of claim 1 wherein a user draws the boundary around the region of interest or draws a plurality of points indicating the boundary around the region of interest.

9. The method of claim 1 wherein a user draws the boundary around the region of interest or draws a plurality of points indicating the boundary around the region of interest using a computer input device.

10. The method of claim 1 wherein a user draws the boundary around the region of interest or draws a plurality of points indicating the boundary around the region of interest using a mouse, touchscreen, trackball, joystick, trackpad, stylus, or light pen.

11. The method of claim 1 wherein automated image processing draws the boundary around the region of interest.

12. The method of claim 1 wherein the boundary is provided on normal biological tissue.

13. The method of claim 1 wherein the lesion is a retinal lesion.

14. The method of claim 1 wherein the lesion is a central neovascularization lesion complex.

15. A method of treating a subject having an eye lesion, the method comprising:

a) acquiring an area and/or a volume of the eye lesion according to the method of claim 1 ;

b) administering a treatment to the subject based on the area and/or the volume of the tissue abnormality.

16. The method of claim 15 wherein the patient has macular degeneration and the region of interest is a central neovascularization lesion complex.

17. The method of claim 15 wherein the treatment comprises administering to the subject an agent targeting vascular endothelial growth factor and/or an agent targeting platelet derived growth factor.

18. A method of identifying that a treatment of a subject having an eye lesion is successful, the method comprising:

a) calculating a first area and/or a first volume of the eye lesion according to the method of claim 1 ;

b) administering a treatment to the subject;

c) calculating a second area and/or a second volume of the eye lesion according to the method of claim 1 ; and

d) identifying the treatment of the patient as effective when the second area and/or the second volume of the eye lesion is less than the first area and/or the first volume of the eye lesion.

19. The method of claim 18 wherein the patient has macular degeneration and the region of interest is a central neovascularization lesion complex.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 17, 2025
From: MERIT CRO, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 069916/0072 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2023
From: HUANG, YIJUN
To: EYEKOR, LLC
Reel/Frame 065968/0068 →
CHANGE OF NAME Recorded Dec 28, 2023
From: EYEKOR, LLC
To: MERIT CRO, INC.
Reel/Frame 065968/0136 →
Continuity (6)
Continuation 17582538 · Jan 24, 2022
Continuation 16519061 · Jul 23, 2019
Continuation 15072046 · Mar 16, 2016
Provisional Application 62269601 · Dec 18, 2015
Provisional Application 62138485 · Mar 26, 2015
Related Publication 20240193771A1 · Jun 13, 2024
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