METHODS OF USING COMPOSITIONS COMPRISING AN ICELAND MOSS EXTRACT
Provided are methods of reducing pain or itch, the method comprising administering to a patient in need thereof a therapeutically effective dose of a composition comprising a non-polar extract of Iceland moss.
1 . A method of reducing pain or itch, the method comprising administering to a patient in need thereof a composition comprising a therapeutically effective dose of non-polar extract of Iceland moss.
2 . The method of claim 1 , wherein the non-polar extract was extracted with one or more solvents selected from the group consisting of C 1 -C 8 alkanes, C 1 -C 8 cycloalkanes, C 1 -C 8 alkyl ethers, petroleum ethers, C 1 -C 8 ketones, methylene chloride, ethyl acetate, xylene, toluene, chloroform, vegetable oil, mineral oil, and combinations thereof.
3 . The method of claim 1 , wherein the pain is TRPA1 or TrKA receptor-mediated pain and/or itch.
4 . The method of claim 1 , wherein the composition is administered enterally, applied to a surface of skin of the patient, or is administered to the eye of the patient.
5 . The method of claim 1 , wherein the pain or itch is associated with digestive health, ocular itch, osteoarthritis, allergy, or atopic dermatitis.
6 . The method of claim 1 , wherein the composition further comprises a dermatologically acceptable carrier selected from the group consisting of surfactants, chelating agents, emollients, humectants, conditioners, preservatives, opacifiers, fragrances, and combinations of two or more thereof.
7 . The method of claim 1 , wherein the composition is administered in the form of a solution, suspension, lotion, cream, serum, gel, stick, spray, ointment, liquid wash, soap bar, shampoo, hair conditioner, paste, foam, powder, mousse, shaving cream, hydrogel, or film-forming product.
8 . The method of claim 1 , wherein the non-polar extract is present in the composition at a concentration of about 0.00001 to about 2 wt. % by weight of the total composition.
9 . A composition comprising a therapeutically effective dose of non-polar extract of Iceland moss for use in reducing pain or itch to a patient in need thereof
wherein the non-polar extract is present in the composition at a concentration of about 0.001 to about 0.005 wt. % by weight of the total composition; and
the non-polar extract was extracted with dichloromethane.
10 . (canceled)
11 . (canceled)
12 . (canceled)
13 . (canceled)
14 . The composition of claim 9 , wherein the composition further comprises a dermatologically acceptable carrier selected from the group consisting of surfactants, chelating agents, emollients, humectants, conditioners, preservatives, opacifiers, fragrances, and combinations of two or more thereof.
15 . The composition of claim 9 , wherein the composition is administered in the form of a solution, suspension, lotion, cream, serum, gel, stick, spray, ointment, liquid wash, soap bar, shampoo, hair conditioner, paste, foam, powder, mousse, shaving cream, hydrogel, or film-forming product.
16 . The method of claim 2 , wherein the non-polar extract was extracted with dichloromethane.
17 . The method of claim 8 , wherein the non-polar extract is present in the composition at a concentration of about 0.001 to about 0.005 wt. % by weight of the total composition.