VIRAL FILTRATION MEDIA, ARTICLES, AND METHODS
Viral filtration media, an article comprising the viral filtration media, and a method of filtering a virus-containing sample using the viral filtration media, wherein the viral filtration media comprises: a porous substrate comprising a surface having a polymer grafted thereto, wherein the grafted polymer comprises interpolymerized monomers comprising: a (meth)acrylic acid monomer: and, optionally, a poly (alkylene oxide) monomer.
1 . Viral filtration media comprising:
a porous substrate comprising a surface having a polymer grafted thereto, wherein the grafted polymer comprises interpolymerized monomers comprising:
a (meth)acrylic acid monomer; and
a poly(alkylene oxide) monomer optionally including a hydrocarbon chain.
2 . The filtration media of claim 1 wherein the (meth)acrylic acid monomer is methacrylic acid.
3 . The filtration media of claim 1 wherein the poly(alkylene oxide) monomer has the formula:
wherein:
Z is a polymerizable ethylenically unsaturated group;
Q is a divalent linking group;
R 1 is H or an alkyl group;
R 2 is H or an alkyl group; and
m is 2 to 100.
4 . The filtration media of claim 3 wherein Z is selected from the group consisting of:
wherein:
R 3 is H or CH 3 ; and
r is 1-10.
5 . The filtration media of claim 3 where Q is selected from the group consisting of: —O—,
—NR 3 —, —C(O)O—, and —C(O)NR 3 —, wherein R 3 is H or CH 3 .
6 . The filtration media of claim 3 wherein R 2 is an alkyl group.
7 . The filtration media of claim 3 wherein m is 2 to 50.
8 . The filtration media of claim 1 wherein the poly(alkylene oxide) monomer is present in an amount of 2 wt-% to 75 wt-%, based on the total weight of the interpolymerized monomers.
9 . The filtration media of claim 1 wherein the porous substrate is a porous polymeric nonwoven substrate.
10 . An article comprising the viral filtration media of claim 1 .
11 . A method of filtering a virus-containing sample, the method comprising:
providing a viral filtration media comprising:
a porous substrate comprising a surface having a polymer grafted thereto,
wherein the grafted polymer comprises interpolymerized monomers comprising:
a (meth)acrylic acid monomer;
providing a virus-containing sample comprising a target virus; and
contacting the viral filtration media with the virus-containing sample under conditions effective to separate at least a portion of the target virus from other material in the virus-containing sample.
12 . The method of claim 11 wherein the interpolymerized monomers comprise: a (meth)acrylic acid monomer; and a poly(alkylene oxide) monomer optionally including a hydrocarbon chain.
13 . The method of claim 11 wherein contacting comprises allowing a moving virus-containing sample to impinge upon an upstream surface of the filtration media for a time sufficient to effect separation of at least a portion of the target virus from other material in the virus-containing sample.
14 . The method of claim 13 wherein contacting comprises allowing a moving virus-containing sample to impinge upon an upstream surface of the filtration media for a time sufficient to effect binding of at least a portion of the target virus in the virus-containing sample to the filtration media.
15 . The method of claim 13 wherein contacting comprises allowing a moving virus-containing sample to impinge upon an upstream surface of the filtration media for a time sufficient to effect binding of at least a portion of other material in the virus-containing sample to the filtration media.
16 . The method of claim 13 wherein contacting comprises allowing a moving virus-containing sample to impinge upon an upstream surface of the filtration media for a time sufficient to effect separation of at least a portion of the target virus from another virus in the virus-containing sample.