IP Library › Granted Patent US 12,310,981
Granted Patent B2
US 12,310,981 · App. 18/555,982 · Granted May 27, 2025

Use of chondroitin sulfate for relieving ocular pain

Inventors: Richard L. Lindstrom (Wayzata, MN); Kamran Hosseini (Pleasanton, CA); Lyle Bowman (Pleasanton, CA)
Assignee: SURFACE OPHTHALMICS, INC.
A61K31/737A61K9/0048
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Quick Facts
Patent No.
US 12,310,981
App. No.
18/555,982
Granted
May 27, 2025
Kind
B2
Abstract

Chondroitin sulfate-based pharmaceutical formulations useful for the treatment of ocular pain or discomfort, such as occurring from ocular surgery, dry eye disease, ocular surgery induced dry eye disease, contact lens induced ocular surface dry eye disease, preservative induced ocular surface disease, conjunctivitis, corneal abrasion, burns, blepharitis, and stye.

Claims (10)

1. A method of treating ocular pain or discomfort after ocular surgery, the method comprising: topically administering eye drops to an eye of a subject that has undergone ocular surgery, a therapeutically effective amount of a composition consisting essentially of 0.1% to 1.0% wt/wt chondroitin sulfate and a lubricant in a pharmaceutically acceptable carrier.

2. The method of claim 1 , wherein the ocular surgery is cataract surgery.

3. The method of claim 1 , wherein the composition is administered over at least 7 days, optionally for 14 days or more.

4. The method of claim 1 , wherein the lubricant comprises Dextran-70 and glycerol.

5. A method of treating ocular pain or discomfort after ocular surgery, the method comprising: topically administering eye drops to an eye of a subject that has undergone ocular surgery, a composition comprising 0.1% to 1.0% wt/wt chondroitin sulfate in a pharmaceutically acceptable carrier.

6. The method of claim 5 , wherein the composition is free of corticosteroids.

7. The method of claim 5 , wherein the composition is administered for at least 7 days.

8. The method of claim 5 , wherein the composition further comprises a lubricant in the pharmaceutically acceptable carrier.

9. The method of claim 8 , wherein the lubricant comprises Dextran-70 and glycerol.

10. The method of claim 5 , wherein the ocular surgery is cataract surgery.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 10, 2024
From: LINDSTROM, RICHARD L.; HOSSEINI, KAMRAN; BOWMAN, LYLE
To: SURFACE OPHTHALMICS, INC.
Reel/Frame 067674/0822 →
Continuity (2)
Provisional Application 63186747 · May 10, 2021
Related Publication 20240207305A1 · Jun 27, 2024
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