BIS-RNAI COMPOUNDS FOR CNS DELIVERY

Inventors: Ivan ZLATEV, Christopher S. THEILE, Muthiah MANOHARAN, Scott P. LENTINI, Shigeo MATSUDA, Jayaprakash K. NAIR, Haiyan PENG

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Non Final Action Counted, Not Yet Mailed View Publication ↗

	Code	Description	Pages	PDF
2026-07-31	`ELC.`	Response to Election / Restriction Filed	—	View
2026-07-31	`ELC.`	Response to Election / Restriction Filed	1	View
2026-07-31	`CLM`	Claims	8	View
2026-07-31	`REM`	Applicant Arguments/Remarks Made in an Amendment	5	View
2026-07-31	`N417.PYMT`	Electronic Fee Payment	2	View
2026-07-31	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-07-31	`WFEE`	Fee Worksheet (SB06)	1	View
2026-06-04	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2026-06-04	`FOR`	Foreign Reference	183	View
2026-06-04	`FOR`	Foreign Reference	221	View
2026-06-04	`FOR`	Foreign Reference	406	View
2026-06-04	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-06-04	`CTRS`	Requirement for Restriction/Election	10	View
2025-08-28	`NTC.PUB`	Notice of Publication	1	View
2025-05-22	`APP.FILE.REC`	Filing Receipt	4	View
2025-05-22	`M903`	Notice of Designated Office (DO) / Elected Office (EO) Acceptance Mailed	2	View
2025-05-22	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2025-05-22	`WFEE`	Fee Worksheet (SB06)	1	View
2024-09-25	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	—	View
2024-09-25	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	17	View
2024-09-24	`PEFRSEQ`	Response to Pre-Exam Sequence Notice	—	View
2024-09-24	`PEFRSEQ`	Response to Pre-Exam Sequence Notice	1	View
2024-09-24	`SPEC`	Specification	1	View
2024-09-24	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2024-09-24	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2024-09-24	`LET.`	Miscellaneous Incoming Letter	3	View
2024-09-24	`SEQ.XML`	Sequence Listing (XML File)	1	View
2024-07-24	`PD.AUTH.G`	Acceptance of Permission to Access Application	1	View
2024-07-24	`SREXR.G`	Acceptance of Permission to Access Search Results	1	View
2024-07-24	`371.RQ.M922`	371 (National Stage) Requirements for Sequence Disclosure Notice Form M922	3	View
2024-07-24	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2024-07-24	`WFEE`	Fee Worksheet (SB06)	1	View
2024-07-24	`WELCOME.LET`	Welcome Letter from USPTO Director and Deputy Director	1	View
2024-01-26	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-01-26	`OATH`	Oath or Declaration filed	7	View
2024-01-08	`SPEC`	Specification	—	View
2024-01-08	`A.PE`	Preliminary Amendment	—	View
2024-01-08	`N417.PYMT`	Electronic Fee Payment	2	View
2024-01-08	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2024-01-08	`TRNA`	Transmittal of New Application	4	View
2024-01-08	`PA..`	Power of Attorney	2	View
2024-01-08	`FOR`	Foreign Reference	271	View
2024-01-08	`371P`	Documents submitted with 371 (National Stage) Applications	7	View
2024-01-08	`ADS`	Application Data Sheet	10	View
2024-01-08	`FOR`	Foreign Reference	138	View
2024-01-08	`A.PE`	Preliminary Amendment	1	View
2024-01-08	`SPEC`	Specification	1	View
2024-01-08	`CLM`	Claims	8	View
2024-01-08	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2024-01-08	`N417`	Electronic Filing System Acknowledgment Receipt	6	View
2024-01-08	`371P`	Documents submitted with 371 (National Stage) Applications	402	View
2024-01-08	`DRW.NONBW`	Drawings-other than black and white line drawings	57	View
2024-01-08	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2024-01-08	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2024-01-08	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2024-01-08	`FRPR`	Certified Copy of Foreign Priority Application	226	View
2024-01-08	`P.N.101.CONV`	PCT/RO/101 - Request form for new International Application - Conventional	5	View
2024-01-08	`FRPR`	Certified Copy of Foreign Priority Application	270	View
2024-01-08	`ABST`	Abstract	1	View
2024-01-08	`CLM`	Claims	12	View
2024-01-08	`DRW`	Drawings-only black and white line drawings	57	View
2024-01-08	`ABST`	Abstract	1	View
2024-01-08	`SPEC`	Specification	332	View
2024-01-08	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View

Inventors

Ivan ZLATEV Cambridge, MA

Christopher S. THEILE Cambridge, MA

Muthiah MANOHARAN Cambridge, MA

Scott P. LENTINI Cambridge, MA

Shigeo MATSUDA Cambridge, MA

Jayaprakash K. NAIR Cambridge, MA

Haiyan PENG Cambridge, MA

Attorneys & Agents of Record

SARAH FENDRICK Reg. 66262 Attorney · ALNYLAM PHARMACEUTICALS

HONGLING ZOU Reg. 68459 Attorney · COZEN O'CONNOR

JEFFERY TOWNES Reg. 47142 Agent · LECLAIRRYAN

Classification

USPC 514/44A

C12N15/1137 C12N15/113 C12N2310/14 C12N2310/321 C12N2310/351 C12N2310/532

Prosecution

Examiner: ZAHORIK, AMANDA MARY
Art Unit: 1636
Customer No.: 84717
Docket No.: 29520.1507-US/598482
Confirmation No.: 8018

Publication

Pub. No.: US20250270562A1
Pub. Date: 2025-08-28

BANK OF AMERICA, N.A.

from ALNYLAM PHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC.

SECURITY INTEREST Recorded 2025-10-01

072996/0337 →

ALNYLAM PHARMACEUTICALS, INC.

from PENG, HAIYAN, THEILE, CHRISTOPHER S., ZLATEV, IVAN, LENTINI, SCOTT P., MANOHARAN, MUTHIAH, MATSUDA, SHIGEO, NAIR, JAYAPRAKASH K.

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2024-01-26

066259/0842 →

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Quick Facts

App. No.: 18/577,377
Filed: 2024-01-08
Pub. No.: US20250270562A1
Examiner: ZAHORIK, AMANDA MARY
Art Unit: 1636

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗