OPHTHALMIC SOLUTIONS
An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.
1 . An ophthalmically compatible solution, comprising:
(a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof;
(b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol;
(c) sodium chloride, potassium chloride or any combination thereof; and
(d) one or more buffers;
wherein the ophthalmically compatible solution is preservative-free.
2 . The ophthalmically compatible solution of claim 1 , comprising:
about 0.01 to about 0.2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; and
about 0.05 to about 0.5 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol.
3 . The ophthalmically compatible solution of claim 1 , comprising:
about 0.01 to about 5 wt. %, based on the total weight of the ophthalmically compatible solution, of the sodium chloride, potassium chloride or any combination thereof; and
about 0.1 to about 10% (w/w) of the one or more buffers.
4 . The ophthalmically compatible solution of claim 1 , wherein the one or more buffers comprise boric acid or a salt thereof.
5 . The ophthalmically compatible solution of claim 1 , comprising:
(a) about 0.01 to about 0.2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof;
(b) about 0.05 to about 0.5 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; and
(c) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of the sodium chloride, potassium chloride or any combination thereof.
6 . The ophthalmically compatible solution of claim 1 , further comprising one or more lubricants.
7 . The ophthalmically compatible solution of claim 6 , wherein the one or more lubricants comprise glycerol.
8 . The ophthalmically compatible solution according to claim 1 , further comprising about 0.01 to about 5 wt. %, based on the total weight of the ophthalmically compatible solution, of one or more lubricants.
9 . The ophthalmically compatible solution of claim 1 , in the form of eye drops.
10 . The ophthalmically compatible solution of claim 1 , which does not contain a surfactant.
11 . A method for reducing, ameliorating, treating, or controlling a condition of dry eye, the method comprising:
administering to an affected eye of a patient an ophthalmically compatible solution comprising (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers; wherein the ophthalmically compatible solution is preservative-free.
12 . The method of claim 11 , wherein the ophthalmically compatible solution comprises:
(a) about 0.01 to about 0.2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof;
(b) about 0.08 to about 0.4 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; and
(c) about 0.01 to about 0.08 wt. %, based on the total weight of the ophthalmically compatible solution, of the sodium chloride, potassium chloride or any combination thereof.
13 . The method of claim 11 , wherein the ophthalmically compatible solution further comprises about 0.01 to about 5 wt. %, based on the total weight of the ophthalmically compatible solution, of one or more lubricants.
14 . The method of claim 11 , wherein the ophthalmically compatible solution is in the form of eye drops.
15 . A method of rewetting a cornea, the method comprising:
administering the ophthalmically compatible solution according to claim 1 to a cornea.
16 . The method of claim 15 , wherein the ophthalmically compatible solution comprises:
(a) about 0.01 to about 0.2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof;
(b) about 0.08 to about 0.4 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; and
(c) about 0.01 to about 0.08 wt. %, based on the total weight of the ophthalmically compatible solution, of the sodium chloride, potassium chloride or any combination thereof.
17 . The method of claim 15 , wherein the ophthalmically compatible solution further comprises about 0.01 to about 5 wt. %, based on the total weight of the ophthalmically compatible solution, of one or more lubricants.
18 . The method of claim 15 , wherein the ophthalmically compatible solution is in the form of eye drops.
19 . A system useful as an artificial tear or for rewetting or lubricating a cornea, the system comprising a drop dispenser capable of holding between about 1 and about 30 ml of the ophthalmically compatible solution of claim 1 .
20 . An ophthalmically compatible solution, consisting essentially of:
(a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof;
(b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol;
(c) sodium chloride, potassium chloride or any combination thereof; and
(d) one or more buffers;
wherein the ophthalmically compatible solution is preservative-free.