IP Library Granted Patent US 12,345,363
Granted Patent B2
US 12,345,363 · App. 18/588,971 · Granted Jul 1, 2025

Multiport disconnect couplings

Inventors: Sandor Kovacs (Middletown, DE); David Baranson (Encinitas, CA)
Assignee: Singular Genomics Systems, Inc.
F16L39/00B01L2200/027F16L37/56F16L2201/40
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Quick Facts
Patent No.
US 12,345,363
App. No.
18/588,971
Granted
Jul 1, 2025
Kind
B2
Abstract

A connector assembly is configured to fluidly and removably connect a first set of microtubes to a second set of microtubes of a microfluidic device. The connector assembly provides multiple points of contact to the microtubes to provide a secure connection between the connector assembly and the microtubes. A single gasket provides a securely aligned connection between microtubes.

Claims (32)

1. A multiport coupling device of a microfluidic device, comprising:

a first connector that includes at least two bores;

a second connector that includes at least two bores, wherein the second connector couples to the first connector;

a gasket seated in the first connector, wherein the gasket defines a connection location configured to receive at least a first microtube and a second microtube and wherein the connection location of the gasket provides a seal between the first microtube and the second microtube and wherein the gasket is positioned between the first connector and the second connector when the first connector couples to the second connector;

a first set of threads configured to retain the first microtube within the multiport coupling device; and

a second set of threads configured to retain the second microtube within the multiport coupling device.

2. The multiport coupling device of claim 1 , wherein the gasket is the sole gasket of the multiport coupling device.

3. The multiport coupling device of claim 1 , wherein the at least two bores of the first connector co-axially align with the at least two bores of the second connector when the first connector couples to the second connector.

4. The multiport coupling device of claim 3 , wherein the gasket includes at least two bores that co-axially align with the at least two bores of the first connector and the at least two bores of the second connector when the first connector couples to the second connector.

5. The multiport coupling device of claim 1 , further comprising one or more alignment pins that are configured to mate and align the first connector and second connector in a proper orientation.

6. The multiport coupling device of claim 1 , wherein the first connector couples to the second connector in a male-female relationship.

7. The multiport coupling device of claim 1 , wherein the first connector includes a male member that inserts into the second connector.

8. The multiport coupling device of claim 1 , wherein the first connector includes a notch that is sized and shaped to receive a complementary key of the second connector.

9. The multiport coupling device of claim 1 , further comprising the first microtube and the second microtube.

10. The multiport coupling device of claim 1 , wherein the first connector attaches to a first set of microtubes that includes the first microtube and a second set of microtubes that includes the second microtube.

11. The multiport coupling device of claim 1 , wherein the first set of threads are on a first cap co-axially coupled to the first connector and wherein the first set of threads are configured to extend along a length of the first microtube.

12. The multiport coupling device of claim 1 , wherein the first cap defines an annular opening that receives at least a portion of the first connector.

13. A microfluidic device, comprising:

two or more inlet microtubes;

two or more outlet microtubes;

a multiport coupling device configured to connect the two or more inlet microtubes to the two or more outlet microtubes at a connection location, the multiport connector comprising:

a first connector that includes a plurality of bores in which the two or more inlet microtubes are seated;

a second connector that includes a plurality of bores in which the two or more outlet microtubes are seated, wherein the second connector couples to the first connector;

a gasket seated in the first connector, wherein the connection location is positioned entirely within the gasket, wherein the gasket is positioned between the first connector and the second connector when the first connector couples to the second connector;

a first set of threads of the plurality of bores of the first connector, the first set of threads configured to retain the two or more inlet microtubes within the first connector; and

a second set of threads of the plurality of bores of the second connector, the second set of threads configured to retain the two or more outlet microtubes within the second connector.

14. The microfluidic device of claim 13 , wherein the gasket is the sole gasket of the multiport coupling device.

15. The microfluidic device of claim 13 , further comprising one or more alignment pins that are configured to mate and align the first connector and second connector in a proper orientation.

16. The microfluidic device of claim 13 , wherein the first connector couples to the second connector in a male-female relationship.

17. The microfluidic device of claim 16 , wherein the first connector includes a male member that inserts into the second connector.

18. The microfluidic device of claim 13 , wherein the first set of threads are on a first cap co-axially coupled to the first connector and wherein the first set of threads are configured to extend along a length of the first microtube.

19. The microfluidic device of claim 13 , wherein the first cap defines an annular opening that receives at least a portion of the first connector.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 18, 2025
From: KOVACS, SANDOR; BARANSON, DAVID
To: SINGULAR GENOMICS SYSTEMS, INC.
Reel/Frame 070549/0803 →
SECURITY INTEREST Recorded Mar 7, 2025
From: SINGULAR GENOMICS SYSTEMS, INC.
To: FIRST-CITIZENS BANK & TRUST COMPANY
Reel/Frame 070440/0465 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2024
From: KOVACS, SANDOR; BARANSON, DAVID
To: SINGULAR GENOMICS SYSTEMS, INC.
Reel/Frame 067469/0314 →
Continuity (4)
Continuation 17682508 · Feb 28, 2022
Continuation PCTUS2021058660 · Nov 9, 2021
Provisional Application 63114895 · Nov 17, 2020
Related Publication 20240200705A1 · Jun 20, 2024
References Cited (24)
US 2438679A · Parker · 1948 [cited by applicant]
US 3469863A · Riester et al. · 1969 [cited by applicant]
US 3503634A · Cadiou · 1970 [cited by applicant]
US 3960393A · Hosokawa et al. · 1976 [cited by applicant]
US 4630847A · Blenkush · 1986 [cited by applicant]
US 4754993A · Kraynick · 1988 [cited by applicant]
US 4995646A · Johnston · 1991 [cited by examiner]
US 5236227A · Adams et al. · 1993 [cited by applicant]
US 5478119A · Dye · 1995 [cited by applicant]
US 6209928B1 · Benett et al. · 2001 [cited by applicant]
US 6585296B1 · Picha · 2003 [cited by examiner]
US 7311882B1 · Renzi · 2007 [cited by applicant]
US 8039817B2 · Feng et al. · 2011 [cited by applicant]
US 8241573B2 · Banerjee et al. · 2012 [cited by applicant]
US 8622437B2 · Dourdeville · 2014 [cited by examiner]
US 20040238447A1 · Cheong · 2004 [cited by examiner]
US 20060006065A1 · Pinkas et al. · 2006 [cited by applicant]
US 20090121476A1 · Malito et al. · 2009 [cited by applicant]
US 20120270305A1 · Reed et al. · 2012 [cited by applicant]
Brenner, S. et al. (Jun. 2000). “Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays,” [cited by applicant]
Dolomite Inline Interfaces Data Sheet, The Dolomite Centre Ltd located at <https://www.dolomite-microfluidics.com/product/circular-in-line-interface/> last accessed Aug. 16, 2023. [cited by applicant]
International Search Report and Written Opinion mailed on Jan. 31, 2022, for PCT application PCT/US2021/058660, filed Nov. 9, 2021, 8 pages. [cited by applicant]
Margulies, M. et al. (Sep. 15, 2005, e-published Jul. 31, 2005). “Genome sequencing in microfabricated high-density picolitre reactors,” [cited by applicant]
Ronaghi, M. et al. (Jul. 17, 1998). “A sequencing method based on real-time pyrophosphate,” [cited by applicant]