Ocular lubricant formulations
Provided herein are formulations and compositions for ocular diseases or disorders such as dry eye disease. Further provided herein are methods for manufacturing ocular formulations and compositions.
1 . A method of treating dry eye, the method comprising administering to a subject in need thereof a composition consisting of:
(a) povidone;
(b) fully hydrolyzed polyvinyl alcohol;
(c) partially hydrolyzed polyvinyl alcohol;
(d) sodium chloride;
(e) boric acid;
(f) disodium edetate dihydrate;
(g) potassium chloride;
(h) glycerin;
(i) ethyl alcohol;
(j) lecithin;
(k) polysorbate 80;
(l) a pH adjusting agent; and
(m) water;
wherein
the fully hydrolyzed polyvinyl alcohol has a molecular weight in a range of 20,000 to 200,000 daltons;
the composition is an ophthalmic composition; and
the composition is preservative free.
2 . The method of claim 1 , wherein the administration improves or replaces damaged tear film in the subject.
3 . The method of claim 1 , wherein the composition is administered to the subject in one or more daily doses.
4 . The method of claim 1 , wherein the composition is administered in a plurality of daily doses.
5 . The method of claim 1 , wherein the composition is administered from a dropper bottle.
6 . The method of claim 1 , wherein the composition is administered four times per day.
7 . The method of claim 1 , wherein an osmolality of the composition is about 200 mOsm/kg to about 400 mOsm/kg.