IP Library Granted Patent US 12,472,295
Granted Patent B2
US 12,472,295 · App. 18/594,854 · Granted Nov 18, 2025

Dialysis system having adaptive prescription management

Inventors: Alex Anping Yu (Safety Harbor, FL); James Grayson (Toronto, CA); Robert W. Childers (New Port Richey, FL)
Assignees: Baxter International Inc.; Baxter Healthcare SA
A61M1/282A61M1/155A61M1/159A61M1/16A61M1/1603A61M1/28A61M1/281A61M1/287A61M1/341B01D61/30B01D61/32G16H20/40A61M1/1522A61M2205/18A61M2205/3303A61M2205/3327A61M2205/3331A61M2205/3553A61M2205/3576A61M2205/3592A61M2205/502A61M2230/005A61M2230/30
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Quick Facts
Patent No.
US 12,472,295
App. No.
18/594,854
Granted
Nov 18, 2025
Kind
B2
Abstract

An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes at least one pump and a memory device configured to store therapy prescriptions including a first ultrafiltration (“UF”) therapy prescription for removing ultrafiltrate from a patient, and a second UF therapy prescription for removing less ultrafiltrate from the patient compared to the first UF therapy prescription. The system further includes a logic implementer configured to receive UF removed data, use the UF removed data to form or update a moving average UF removed trend, and compare the moving average UF removed trend to an expected UF removal trend or an expected UF removal minimum value. When the moving average UF removed trend is below the expected UF removal trend or the expected UF removal minimum value, the logic implementer provides a recommendation that the first UF therapy prescription should be selected for a next peritoneal dialysis treatment.

Claims (81)

1 . A peritoneal dialysis system comprising:

at least one pump;

a memory device configured to store:

therapy prescriptions including:

a high ultrafiltration (“UF”) therapy prescription for removing a first amount of ultrafiltrate from a patient, and

a standard UF therapy prescription for removing a second amount of ultrafiltrate from the patient, the second amount of ultrafiltrate being less than the first amount of ultrafiltrate, or a low UF therapy prescription for removing a third amount of ultrafiltrate from the patient, the third amount of ultrafiltrate being less than the second amount of ultrafiltrate, and

an expected UF removal trend or an expected UF removal minimum value; and

a logic implementer communicatively coupled to the memory device and configured to:

receive UF removed data related to performing the high UF therapy prescription or the low UF therapy prescription or the standard UF therapy prescription for a peritoneal dialysis treatment,

use the UF removed data to form or update a moving average UF removed trend,

compare the moving average UF removed trend to the expected UF removal trend or the expected UF removal minimum value,

when the moving average UF removed trend is below the expected UF removal trend or the expected UF removal minimum value, provide a recommendation, via a user interface, that the high UF therapy prescription should be selected for a next peritoneal dialysis treatment,

receive a selection of the high UF therapy prescription for the next peritoneal dialysis treatment, and

control the at least one pump based on the high UF therapy prescription to perform the next peritoneal dialysis treatment.

2 . The peritoneal dialysis system of claim 1 , wherein the logic implementer is communicatively coupled to a network and further configured to:

receive the therapy prescriptions from a clinician computer or a server via the network; and

store the therapy prescriptions to the memory device.

3 . The peritoneal dialysis system of claim 1 , wherein the logic implementer, the at least one pump, the user interface, and the memory device are housed within an automated peritoneal dialysis (“APD”) machine.

4 . The peritoneal dialysis system of claim 1 , wherein the at least one pump and the memory device are housed within an automated peritoneal dialysis (“APD”) machine, and

wherein the logic implementer and the user interface are housed within a server computer in communication with the APD machine via a network.

5 . The peritoneal dialysis system of claim 1 , wherein the memory device additionally stores an expected UF removal maximum value, and

wherein the logic implementer is further configured to:

compare the moving average UF removed trend additionally to the expected UF removal maximum value,

when the moving average UF removed trend is above the expected UF removal trend or the expected UF removal maximum value, provide a second recommendation, via the user interface, that the low UF therapy prescription or the standard UF therapy prescription should be selected for the next peritoneal dialysis treatment,

receive a selection of the low UF therapy prescription or the standard UF therapy prescription for the next peritoneal dialysis treatment, and

control the at least one pump based on the low UF therapy prescription or the standard UF therapy prescription to perform the next peritoneal dialysis treatment.

6 . The peritoneal dialysis system of claim 1 , wherein the peritoneal dialysis treatment and the next peritoneal dialysis treatment each includes at least one of a tidal dialysis therapy a continuous cycling peritoneal dialysis therapy (“CCPD”).

7 . A peritoneal dialysis system comprising:

at least one pump;

a memory device configured to store:

therapy prescriptions including:

a high ultrafiltration (“UF”) therapy prescription for removing a first amount of ultrafiltrate from a patient, and

a standard UF therapy prescription for removing a second amount of ultrafiltrate from the patient, the second amount of ultrafiltrate being less than the first amount of ultrafiltrate, or a low UF therapy prescription for removing a third amount of ultrafiltrate from the patient, the third amount of ultrafiltrate being less than the second amount of ultrafiltrate; and

a logic implementer communicatively coupled to the memory device and configured to:

receive UF removed data related to performing the high UF therapy prescription or the low UF therapy prescription or the standard UF therapy prescription for a peritoneal dialysis treatment,

use the UF removed data to form or update a moving average UF removed trend,

determine a trending range around the moving average UF removed trend,

determine a lower UF removed limit from the trending range,

compare the moving average UF removed trend to the lower UF removed limit from the trending range,

when the moving average UF removed trend is below the lower UF removed limit, provide a recommendation, via a user interface, that the high UF therapy prescription should be selected for a next peritoneal dialysis treatment,

receive a selection of the high UF therapy prescription for the next peritoneal dialysis treatment, and

control the at least one pump based on the high UF therapy prescription to perform the next peritoneal dialysis treatment.

8 . The peritoneal dialysis system of claim 7 , wherein the logic implementer is further configured to:

determine an upper UF removed limit from the trending range;

when the moving average UF removed trend is above the upper UF removed limit, provide a second recommendation, via the user interface, that the low UF therapy prescription or the standard UF therapy prescription should be selected for the next peritoneal dialysis treatment;

receive a selection of the low UF therapy prescription or the standard UF therapy prescription for the next peritoneal dialysis treatment; and

control the at least one pump based on the low UF therapy prescription or the standard UF therapy prescription to perform the next peritoneal dialysis treatment.

9 . The peritoneal dialysis system of claim 8 , wherein the logic implementer determines the upper UF removed limit by adding a factor multiplied by the trending range to the moving average UF removed trend, and the logic implementer determines the lower UF removed limit by subtracting the factor multiplied by the trending range to the moving average UF removed trend.

10 . The peritoneal dialysis system of claim 7 , wherein the logic implementer is configured to provide the recommendation when the moving average UF removed trend is below the lower UF removed limit for a certain number of consecutive days.

11 . The peritoneal dialysis system of claim 10 , wherein the certain number of consecutive days is between three and seven days.

12 . The peritoneal dialysis system of claim 7 , wherein the logic implementer is configured to:

receive a value indicative of a blood pressure of the patient; and

provide the recommendation when the moving average UF removed trend is below the lower UF removed limit and the value indicative of the patient's blood pressure rises above a limit.

13 . The peritoneal dialysis system of claim 7 , wherein the peritoneal dialysis treatment each and the next peritoneal dialysis treatment include at least one of a tidal dialysis therapy or a continuous cycling peritoneal dialysis therapy (“CCPD”).

14 . The peritoneal dialysis system of claim 7 , wherein the logic implementer is communicatively coupled to a network and further configured to:

receive the therapy prescriptions from a clinician computer or a server via the network; and

store the therapy prescriptions to the memory device.

15 . The peritoneal dialysis system of claim 7 , wherein the logic implementer, the at least one pump, the user interface, and the memory device are housed within an automated peritoneal dialysis (“APD”) machine.

16 . The peritoneal dialysis system of claim 7 , wherein the at least one pump and the memory device are housed within an automated peritoneal dialysis (“APD”) machine, and

wherein the logic implementer and the user interface are housed within a server computer in communication with the APD machine via a network.

17 . A peritoneal dialysis system comprising:

at least one pump;

a memory device configured to store:

therapy prescriptions including:

a first ultrafiltration (“UF”) therapy prescription for removing ultrafiltrate from a patient, and

a second UF therapy prescription for removing less ultrafiltrate from the patient compared to the first UF therapy prescription; and

a logic implementer communicatively coupled to the memory device and configured to:

receive UF removed data related to performing peritoneal dialysis treatments,

use the UF removed data to form or update a moving average UF removed trend,

compare the moving average UF removed trend to an expected UF removal trend or an expected UF removal minimum value,

when the moving average UF removed trend is below the expected UF removal trend or the expected UF removal minimum value, provide a recommendation, via a user interface, that the first UF therapy prescription should be selected for a next peritoneal dialysis treatment,

receive a selection of the first UF therapy prescription for the next peritoneal dialysis treatment, and

control the at least one pump based on the first UF therapy prescription to perform the next peritoneal dialysis treatment.

18 . The peritoneal dialysis system of claim 17 , wherein the logic implementer is further configured to:

compare the moving average UF removed trend additionally to an expected UF removal maximum value;

when the moving average UF removed trend is above the expected UF removal trend or the expected UF removal maximum value, provide a second recommendation, via the user interface, that the second UF therapy prescription should be selected for the next peritoneal dialysis treatment,

receive a selection of the second UF therapy prescription for the next peritoneal dialysis treatment; and

control the at least one pump based on the second UF therapy prescription to perform the next peritoneal dialysis treatment.

19 . The peritoneal dialysis system of claim 17 , wherein the logic implementer, the at least one pump, the user interface, and the memory device are housed within an automated peritoneal dialysis (“APD”) machine.

20 . The peritoneal dialysis system of claim 17 , wherein the at least one pump and the memory device are housed within an automated peritoneal dialysis (“APD”) machine, and

wherein the logic implementer and the user interface are housed within a server computer in communication with the APD machine via a network.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2025
From: BAXTER HEALTHCARE SA
To: VANTIVE HEALTH GMBH
Reel/Frame 073433/0500 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2025
From: BAXTER INTERNATIONAL INC.
To: VANTIVE US HEALTHCARE LLC
Reel/Frame 074041/0750 →
SECURITY INTEREST Recorded Jan 31, 2025
From: VANTIVE US HEALTHCARE LLC; GAMBRO RENAL PRODUCTS, INC.
To: ARES CAPITAL CORPORATION
Reel/Frame 070076/0701 →
CHANGE OF CORPORATE ADDRESS Recorded Sep 23, 2024
From: BAXTER HEALTHCARE CORPORATION
To: BAXTER HEALTHCARE SA
Reel/Frame 069022/0403 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2024
From: YU, ALEX ANPING; GRAYSON, JAMES; CHILDERS, ROBERT W.
To: BAXTER INTERNATIONAL INC.; BAXTER HEALTHCARE SA
Reel/Frame 068662/0445 →
Continuity (8)
Continuation 17727334 · Apr 22, 2022
Continuation 16871558 · May 11, 2020
Continuation 16141353 · Sep 25, 2018
Division 14518274 · Oct 20, 2014
Continuation 13679525 · Nov 16, 2012
Continuation 13274012 · Oct 14, 2011
Continuation 12170220 · Jul 9, 2008
Related Publication 20240207498A1 · Jun 27, 2024
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