Roflumilast formulations with an improved pharmacokinetic profile
An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.
1. A topical roflumilast pharmaceutical composition comprising:
(i) roflumilast in an amount of 0.05-1.0% w/w;
(ii) water;
(iii) a hydrophobic component;
(iv) a solvent comprising diethylene glycol monoethyl ether; and
(v) a surfactant;
wherein said topical roflumilast composition is an emulsion, and
wherein said topical roflumilast composition has a roflumilast absorption profile that produces in a patient following administration, a flattened plasma concentration time curve at steady state relative to oral administration of 500 mcg roflumilast.
2. The composition of claim 1 , wherein the surfactant comprises a blend of ceteraryl alcohol, dicetyl phosphate, and ceteth-10 phosphate.
3. The composition of claim 2 , wherein the hydrophobic component comprises petrolatum.
4. The composition of claim 3 , wherein the topical roflumilast composition produces a Cmax between about 0.5 ng/ml and about 7.34 ng/ml at steady state.
5. The composition of claim 4 , wherein the topical roflumilast composition produces a Cmax less than 3.99 ng/ml at steady state.
6. The composition of claim 5 , wherein the topical roflumilast composition produces a Cmax between about 1 ng/ml and about 2 ng/mL at steady state.
7. The composition of claim 4 , wherein the composition comprises 25% w/w of diethylene glycol monoethyl ether and 10% w/w of the surfactant.
8. The composition of claim 1 , wherein the hydrophobic component comprises petrolatum.
9. The composition of claim 8 , wherein the topical roflumilast composition produces a Cmax between about 0.5 ng/mL and about 7.34 ng/ml at steady state.
10. The composition of claim 9 , wherein the topical roflumilast composition produces a Cmax less than 3.99 ng/ml at steady state.
11. The composition of claim 10 , wherein the topical roflumilast composition produces a Cmax between about 1 ng/mL and about 2 ng/mL at steady state.
12. The composition of claim 9 , wherein the composition comprises 25% w/w of diethylene glycol monoethyl ether and 10% w/w of the surfactant.
13. The composition of claim 1 , wherein the topical roflumilast composition produces a Cmax between about 0.5 ng/ml and about 7.34 ng/ml at steady state.
14. The composition of claim 13 , wherein the topical roflumilast composition produces a Cmax less than 3.99 ng/ml at steady state.
15. The composition of claim 14 , wherein the topical roflumilast composition produces a Cmax between about 1 ng/ml and about 2 ng/ml at steady state.
16. The composition of claim 13 , wherein the composition comprises 25% w/w of diethylene glycol monoethyl ether and 10% w/w of the surfactant.
17. The composition of claim 1 , wherein the composition comprises 25% w/w of diethylene glycol monoethyl ether.
18. The composition of claim 1 , wherein the peak to trough ratio of roflumilast blood plasma concentration is less than 2 at steady state.
19. The composition of claim 18 , wherein the peak to trough ratio is approximately 1 at steady state.