SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS
Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.
1 . A method of treating clot material in a vasculature of a patient, the method comprising:
advancing a catheter at least partially through the vasculature of the patient such that a distal end portion of the catheter is positioned proximate to the clot material;
actuating a hemostasis valve from a first position to a second position, wherein a valve lumen of the hemostasis valve is constricted in the first position to inhibit fluid flow from a catheter lumen of the catheter through the valve lumen, and wherein the valve lumen is at least partially open in the second position to permit fluid flow from the catheter lumen through the valve lumen;
detecting blood flow through the valve lumen while the hemostasis valve is in the second position;
determining that the distal end portion of the catheter is positioned proximal to the clot material based on the detected blood flow; and
after determining that the distal end portion of the catheter is positioned proximal to the clot material, aspirating the catheter lumen such that at least a portion of the clot material is aspirated into the catheter lumen.
2 . The method of claim 1 wherein the method further comprises:
after determining that the distal end portion of the catheter is positioned proximal of the clot material based on the detected blood flow, moving the hemostasis valve to the first position; and
while the hemostasis valve is in the first position, aspirating the catheter lumen such that the at least portion of the clot material is aspirated into the catheter lumen
3 . The method of claim 1 wherein detecting blood flow through the valve lumen comprises detecting a first level of blood flow, and wherein the method further comprises:
before detecting the first level of blood flow through the valve lumen, detecting a second level of blood flow through the valve lumen while the hemostasis valve is in the second position;
determining that the distal end portion of the catheter is positioned within the clot material based on the detected second level of blood flow; and
retracting the catheter proximally through the vasculature.
4 . The method of claim 3 wherein the second level of blood flow is less than the first level of blood flow.
5 . The method of claim 3 wherein the second level of blood flow comprises no blood flow.
6 . The method of claim 1 wherein the catheter lumen is fluidly coupled along a fluid path to an aspiration container, and wherein aspirating the catheter lumen comprises:
generating vacuum pressure in the aspiration container while an aspiration valve positioned along the fluid path between the catheter and the aspiration container is in a first position that inhibits fluid flow along the fluid path from the catheter lumen to the aspiration container; and
moving the aspiration valve from the first position with the vacuum pressure generated in the aspiration container to a second position, thereby applying the vacuum pressure to the catheter lumen such that the at least portion of the clot material is aspirated into the catheter lumen, wherein in the second position the valve permits fluid flow along the fluid path from the catheter lumen to the aspiration container.
7 . The method of claim 6 wherein the clot material comprises a pulmonary embolism.
8 . The method of claim 7 wherein advancing the catheter comprises advancing the catheter such that the distal end portion of the catheter is positioned proximate to the pulmonary embolism within a pulmonary artery of the vasculature of the patient.
9 . The method of claim 8 wherein the catheter has a size of 16 French or greater.
10 . The method of claim 6 wherein the clot material comprises a deep vein thrombosis.
11 . The method of claim 10 wherein advancing the catheter comprises advancing the catheter such that the distal end portion of the catheter is positioned proximate to the deep vein thrombosis within a peripheral portion of the vasculature of the patient.
12 . The method of claim 11 wherein the catheter has a size of 16 French or greater.
13 . The method of claim 1 wherein moving the hemostasis valve from the first position to the second position comprises depressing at least one button of the hemostasis valve, and wherein the hemostasis valve comprises a biasing member configured to bias the hemostasis valve to the first position.
14 . The method of claim 1 wherein the hemostasis valve comprises a tubular member at least partially defining the valve lumen and a pair of filaments extending at least partially around the tubular member, wherein in the first position the filaments circumferentially constrict the tubular member such that the valve lumen is constricted, and wherein in the second position the filaments are moved such that the valve lumen is at least partially open.
15 . The method of claim 14 wherein moving the hemostasis valve from the first position to the second position comprises depressing at least one button of the hemostasis valve to reduce a tension in the filaments.
16 . The method of claim 14 wherein the hemostasis valve further comprises a biasing member configured to bias the hemostasis valve to the first position.
17 . A method of treating clot material in a vasculature of a patient, the method comprising:
advancing a catheter at least partially through the vasculature of the patient such that a distal end portion of the catheter is positioned proximate to the clot material;
actuating a hemostasis valve from a first position to a second position, wherein a valve lumen of the hemostasis valve is constricted in the first position to inhibit fluid flow from a catheter lumen of the catheter through the valve lumen, and wherein the valve lumen is at least partially open in the second position to permit fluid flow from the catheter lumen through the valve lumen;
detecting a first level of blood flow through the valve lumen while the hemostasis valve is in the second position;
determining that the distal end portion of the catheter is positioned within the clot material based on the detected first level of blood flow;
retracting the catheter proximally through the vasculature until detecting a second level of blood flow through the valve lumen while the hemostasis valve is in the second position, wherein the second level of blood flow is greater than the first level of blood flow;
determining that the distal end portion of the catheter is positioned proximal to the clot material based on the detected second level of blood flow; and
after determining that the distal end portion of the catheter is positioned proximal to the clot material, aspirating the catheter lumen such that at least a portion of the clot material is aspirated into the catheter lumen.
18 . The method of claim 17 wherein retracting the catheter proximally through the vasculature until detecting the second level of blood flow through the valve lumen comprises retracting the catheter proximally while the hemostasis valve is in the second position.
19 . The method of claim 17 wherein retracting the catheter proximally through the vasculature until detecting the second level of blood flow through the valve lumen comprises:
retracting the catheter proximally through the vasculature to a fixed position while the hemostasis valve is in the first position;
actuating the hemostasis valve from the first position to the second position while the catheter is at the fixed position; and
detecting the second level of blood flow through the valve lumen while the hemostasis valve is in the second position and while the catheter is at the fixed position.
20 . The method of claim 17 wherein the method further comprises:
after determining that the distal end portion of the catheter is positioned proximal of the clot material based on the detected second level of blood flow, moving the hemostasis valve to the first position; and
while the hemostasis valve is in the first position, aspirating the catheter lumen such that the at least portion of the clot material is aspirated into the catheter lumen.
21 . The method of claim 17 wherein the first level of blood flow comprises no blood flow.
22 . The method of claim 17 wherein the catheter lumen is fluidly coupled along a fluid path to an aspiration container, and wherein aspirating the catheter lumen comprises:
generating vacuum pressure in the aspiration container while an aspiration valve positioned along the fluid path between the catheter and the aspiration container is in a first position that inhibits fluid flow along the fluid path from the catheter lumen to the aspiration container; and
moving the aspiration valve from the first position with the vacuum pressure generated in the aspiration container to a second position, thereby applying the vacuum pressure to the catheter lumen such that the at least portion of the clot material is aspirated into the catheter lumen, wherein in the second position the valve permits fluid flow along the fluid path from the catheter lumen to the aspiration container.
23 . The method of claim 22 wherein the clot material comprises a pulmonary embolism, wherein the catheter has a size of 16 French or greater, and wherein advancing the catheter comprises advancing the catheter such that the distal end portion of the catheter is positioned proximate to the pulmonary embolism within a pulmonary artery of the vasculature of the patient.
24 . The method of claim 22 wherein the clot material comprises a deep vein thrombosis, wherein the catheter has a size of 16 French or greater, and wherein advancing the catheter comprises advancing the catheter such that the distal end portion of the catheter is positioned proximate to the deep vein thrombosis within a peripheral portion of the vasculature of the patient.
25 . The method of claim 22 wherein the hemostasis valve comprises a tubular member at least partially defining the valve lumen and a pair of filaments extending at least partially around the tubular member, wherein in the first position the filaments circumferentially constrict the tubular member such that the valve lumen is constricted, wherein in the second position the filaments are moved such that the valve lumen is at least partially open, and wherein moving the hemostasis valve from the first position to the second position comprises depressing at least one button of the hemostasis valve to reduce a tension in the filaments.
26 . The method of claim 25 wherein the hemostasis valve further comprises a biasing member configured to bias the hemostasis valve to the first position.