IP Library › Granted Patent US 12,168,015
Granted Patent B2
US 12,168,015 · App. 18/606,925 · Granted Dec 17, 2024

Aryl-or heteroaryl-substituted benzene compounds

Inventors: Kevin W. Kuntz (Woburn, MA); Richard Chesworth (Concord, MA); Kenneth W. Duncan (Westwood, MA); Heike Keilhack (Belmont, MA); Natalie Warholic (Cambridge, MA); Christine Klaus (Waban, MA); Sarah K. Knutson (Lincoln, MA); Timothy J. N. Wigle (Waltham, MA); Masashi Seki (Tsukuba, JP); Syuji Shirotori (Tsukuba, JP); Satoshi Kawano (Tsukuba, JP)
Assignee: Epizyme, Inc.
A61K31/5377A61K31/4412A61K31/443A61K31/4433A61K31/4436A61K31/4439A61K31/444A61K31/4545A61K31/4709A61K31/496A61K31/506A61K31/551A61K31/553C07D213/64C07D401/12C07D405/12C07D405/14C07D409/12C07D413/12C07D417/12C07D491/08C07D491/107C07D498/08
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Quick Facts
Patent No.
US 12,168,015
App. No.
18/606,925
Granted
Dec 17, 2024
Kind
B2
Abstract

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Claims (4)

1. A pharmaceutically acceptable salt of the following compound:

wherein the pharmaceutically acceptable salt is a hydrobromic acid salt.

2. A pharmaceutical composition comprising a pharmaceutically acceptable salt of the following compound:

wherein the pharmaceutically acceptable salt is a hydrobromic acid salt.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2024
From: KUNTZ, KEVIN W.; CHESWORTH, RICHARD; DUNCAN, KENNETH W.; KEILHACK, HEIKE; WARHOLIC, NATALIE; KLAUS, CHRISTINE; KNUTSON, SARAH K.; WIGLE, TIMOTHY J.N.
To: EPIZYME, INC.
Reel/Frame 068013/0922 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2024
From: SEKI, MASASHI; SHIROTORI, SYUJI; KAWANO, SATOSHI
To: EISAI CO., LTD.
Reel/Frame 068013/0930 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2024
From: EISAI CO., LTD.
To: EISAI R&D MANAGEMENT CO., LTD.
Reel/Frame 068013/0937 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2024
From: EISAI R&D MANAGEMENT CO., LTD.
To: EPIZYME, INC.
Reel/Frame 068013/0940 →
Continuity (14)
Continuation 17308610 · May 5, 2021
Continuation 16660339 · Oct 22, 2019
Continuation 16291800 · Mar 4, 2019
Continuation 15816907 · Nov 17, 2017
Continuation 15598078 · May 17, 2017
Continuation 15346677 · Nov 8, 2016
Continuation 14876658 · Oct 6, 2015
Continuation 14742481 · Jun 17, 2015
Continuation 14275667 · May 12, 2014
Continuation 13722807 · Dec 20, 2012
Continuation 13447007 · Apr 13, 2012
Provisional Application 61499595 · Jun 21, 2011
Provisional Application 61474821 · Apr 13, 2011
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