IP Library Granted Patent US 12,240,848
Granted Patent B2
US 12,240,848 · App. 18/610,051 · Granted Mar 4, 2025

Azaindole rock inhibitors

Inventor: Thomas Maxwell Kaiser (Charleston, SC)
Assignee: Avicenna Biosciences, Inc.
C07D471/04A61K31/4045A61K31/437A61P25/14A61P25/16A61P25/28A61K47/20A61K47/38
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Quick Facts
Patent No.
US 12,240,848
App. No.
18/610,051
Granted
Mar 4, 2025
Kind
B2
Abstract

This invention provides rho-associated protein kinase (ROCK) inhibiting compounds for therapeutic applications as described further herein.

Claims (14)

1. A compound of structure:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.

3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is in the form of a tablet.

4. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is in the form of a capsule.

5. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is in the form of an injection or infusion.

6. A method of treating a ROCK1, ROCK2 or PRKX mediated disorder selected from amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and dementia in a human in need thereof comprising administering an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof; optionally in a pharmaceutical composition, to the human in need thereof.

7. The method of claim 6 , wherein the disorder is mediated by ROCK1.

8. The method of claim 6 , wherein the disorder is mediated by ROCK2.

9. The method of claim 6 , wherein the disorder is mediated by PRKX.

10. The method of claim 6 , wherein the disorder is amyotrophic lateral sclerosis.

11. The method of claim 6 , wherein the disorder is Parkinson's disease.

12. The method of claim 6 , wherein the disorder is Huntington's disease.

13. The method of claim 6 , wherein the disorder is post-traumatic dementia.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2024
From: KAISER, THOMAS MAXWELL
To: AVICENNA BIOSCIENCES, INC.
Reel/Frame 067325/0924 →
Continuity (3)
Continuation PCTUS2023086402 · Dec 29, 2023
Provisional Application 63436408 · Dec 30, 2022
Related Publication 20240254124A1 · Aug 1, 2024
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Cited By (1)
US 12,415,805