BIOPHARMACEUTICAL COMPOSITIONS AND RELATED METHODS

1 .- 30 . (canceled)

31 . A method of treating an IL-5 mediated disease in a patient comprising administering to the patient an antigen binding protein comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 5, the CDRH2 amino acid sequence shown in SEQ ID NO: 6, and the CDRH3 amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 8, the CDRL2 amino acid sequence shown in SEQ ID NO: 9, and the CDRL3 amino acid sequence shown in SEQ ID NO: 10, wherein the disease is selected from the group consisting of asthma, mild asthma, moderate asthma, severe asthma, mild eosinophilic asthma, moderate eosinophilic asthma, severe eosinophilic asthma, uncontrolled eosinophilic asthma, eosinophilic asthma, sub-eosinophilic asthma, chronic obstructive pulmonary disease, eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, nasal polyposis, bullous pemphigoid, eosinophilic esophagitis and atopic dermatitis.

32 . The method of claim 31 , wherein the disease is selected from the group consisting of asthma, mild asthma, moderate asthma, severe asthma, mild eosinophilic asthma, moderate eosinophilic asthma, severe eosinophilic asthma, uncontrolled eosinophilic asthma, eosinophilic asthma, sub-eosinophilic asthma.

33 . The method of claim 32 , wherein the disease is severe asthma.

34 . The method of claim 31 , wherein the disease is eosinophilic granulomatosis with polyangiitis (EGPA).

35 . The method of claim 31 , wherein the disease is hypereosinophilic syndrome (HES).

36 . The method of claim 31 , wherein the disease is nasal polyposis.

37 . The method of claim 31 , wherein the disease is chronic obstructive pulmonary disease (COPD).

38 . The method of claim 31 , wherein the heavy chain variable region further comprises a heavy chain FR4 amino acid sequence as shown in SEQ ID NO: 21.

39 . The method of claim 31 , wherein the antigen binding protein comprises a heavy chain Fc domain having a tyrosine residue at position 252 (265 according to Kabat numbering), a threonine residue at position 254 (267 according to Kabat numbering), and a glutamic acid residue at position 256 (269 according to Kabat numbering).

40 . The method of claim 31 , wherein the antigen binding protein comprises a heavy chain variable region sequence having the amino acid sequence shown in SEQ ID NO: 3; and a light chain variable region sequence having the amino acid sequence shown in SEQ ID NO: 4.

41 . The method of claim 31 , wherein the antigen binding protein comprises a heavy chain Fc domain having a tyrosine residue at position 252 (265 according to Kabat numbering), a threonine residue at position 254 (267 according to Kabat numbering), and a glutamic acid residue at position 256 (269 according to Kabat numbering).

42 . The method of claim 31 , wherein the antigen binding protein comprises a heavy chain having the amino acid sequence shown in SEQ ID NO: 1 and a light chain having the amino acid sequence shown in SEQ ID NO: 2.

43 . A method of treating nasal polyposis in a patient comprising administering to the patient an IL-5 binding protein comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 5, the CDRH2 amino acid sequence shown in SEQ ID NO: 6, and the CDRH3 amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 8, the CDRL2 amino acid sequence shown in SEQ ID NO: 9, and the CDRL3 amino acid sequence shown in SEQ ID NO: 10.

44 . A method of treating hypereosinophilic syndrome (HES) in a patient comprising administering to the patient an IL-5 binding protein comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 5, the CDRH2 amino acid sequence shown in SEQ ID NO: 6, and the CDRH3 amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 8, the CDRL2 amino acid sequence shown in SEQ ID NO: 9, and the CDRL3 amino acid sequence shown in SEQ ID NO: 10.

45 . A method of treating eosinophilic granulomatosis with polyangiitis (EGPA) in a patient comprising administering to the patient an IL-5 binding protein comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 5, the CDRH2 amino acid sequence shown in SEQ ID NO: 6, and the CDRH3 amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 8, the CDRL2 amino acid sequence shown in SEQ ID NO: 9, and the CDRL3 amino acid sequence shown in SEQ ID NO: 10.

46 . A method of treating chronic obstructive pulmonary disease in a patient comprising administering to the patient an IL-5 binding protein comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 5, the CDRH2 amino acid sequence shown in SEQ ID NO: 6, and the CDRH3 amino acid sequence shown in SEQ ID NO: 7; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 8, the CDRL2 amino acid sequence shown in SEQ ID NO: 9, and the CDRL3 amino acid sequence shown in SEQ ID NO: 10.

47 . The method of claim 1 , wherein the antigen binding protein is in a pharmaceutical composition comprising the antigen binding protein and a pharmaceutically acceptable carrier.

48 . The method of claim 1 , wherein the antigen binding protein is administered subcutaneously or intravenously.

49 . The method of claim 1 , wherein the antigen binding protein is administered once every 3 months or once every 6 months.