Neuroactive steroids and their methods of use
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 19 , R 5 , R 3a , R 1a , R 1b , R 2a , R 2b , R 4a , R 4b , R 6a , R 6b , R 7a , R 7b , R 11a , R 11b , R 12a , R 12b , R 18 , R D , and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(O)N(R 55a )(R 55b ), —N(R 55a )(R 55b ), —N(R 55b )C(O)(R 55a ), and R 55C wherein R 55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
1. A compound selected from
Ex-
ample
Structure
299
300
301
302
303
304
307
308
311
312
65
66
341
342
343
344
349
and
350
2. A compound selected from
Ex-
ample
Structure
299
301
303
307
311
65
341
343
and
349
3. A compound selected from
Ex-
ample
Structure
300
302
304
308
312
66
342
and
344
350
4. The compound of claim 1 , wherein the compound has the structural formula
5. The compound of claim 1 , wherein the compound has the structural formula
6. The compound of claim 1 , wherein the compound has the structural formula
7. The compound of claim 1 , wherein the compound has the structural formula
8. The compound of claim 1 , wherein the compound has the structural formula
9. The compound of claim 1 , wherein the compound has the structural formula
10. The compound of claim 1 , wherein the compound has the structural formula
11. The compound of claim 1 , wherein the compound has the structural formula
12. The compound of claim 1 , wherein the compound has the structural formula
13. The compound of claim 1 , wherein the compound has the structural formula
14. The compound of claim 1 , wherein the compound has the structural formula
15. The compound of claim 1 , wherein the compound has the structural formula
16. The compound of claim 1 , wherein the compound has the structural formula
17. The compound of claim 1 , wherein the compound has the structural formula
18. The compound of claim 1 , wherein the compound has the structural formula
19. The compound of claim 1 , wherein the compound has the structural formula
20. The compound of claim 1 , wherein the compound has the structural formula
21. The compound of claim 1 , wherein the compound has the structural formula
22. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
23. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
24. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
25. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
26. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
27. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
28. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
29. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
30. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
31. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
32. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
33. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
34. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
35. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
36. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
37. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
38. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
39. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.