Neuroactive steroids and their methods of use
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 19 , R 5 , R 3a , R 1a , R 1b , R 2a , R 2b , R 4a , R 4b , R 6a , R 6b , R 7a , R 7b , R 11a , R 11b , R 12a , R 12b , R 18 , R D , and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(O)N(R 55a )(R 55b ), —N(R 55a )(R 55b ), —N(R 55b )C(O)(R 55a ), and R 55C wherein R 55c is carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
1. A compound selected from
Exa-
Structure
mple
305
306
317
318
325
326
51
52
355
and
356
2. A compound selected from
Example
Structure
305
317
325
51
and
355
3. A compound selected from
Example
Structure
306
318
326
52
356
4. The compound of claim 1 , wherein the compound has the structural formula
5. The compound of claim 1 , wherein the compound has the structural formula
6. The compound of claim 1 , wherein the compound has the structural formula
7. The compound of claim 1 , wherein the compound has the structural formula
8. The compound of claim 1 , wherein the compound has the structural formula
9. The compound of claim 1 , wherein the compound has the structural formula
10. The compound of claim 1 , wherein the compound has the structural formula
11. The compound of claim 1 , wherein the compound has the structural formula
12. The compound of claim 1 , wherein the compound has the structural formula
13. The compound of claim 1 , wherein the compound has the structural formula
14. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
15. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
16. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
17. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
18. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
19. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
20. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
21. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
22. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.
23. A pharmaceutical composition comprising a compound having the structural formula
and a pharmaceutically acceptable excipient.