METHODS TO INCORPORATE SUBJECTIVE USER GLUCOSE CONCENTRATION FEEDBACK IN AUTOMATED INSULIN DELIVERY SYSTEMS

1 . A drug delivery system, comprising:

a memory storing programming code operable to control delivery of a drug;

a user interface operable to accept an input indicating a perceived glucose state of a user; and

a processor operable to execute the programming code, wherein the programming code causes the processor to:

receive a perceived state signal from the user interface indicating the perceived glucose state of the user;

evaluate the perceived glucose state of the user indicated by the perceived state signal using a glucose measurement value corresponding in time to when the perceived state signal was received;

determine an adjustment to a drug delivery algorithm; and

utilize the adjustment in a determination of a drug delivery dosage to be administered to a user.

2 . The drug delivery system of claim 1 , wherein the programming code further causes the processor to:

based on a result of the perceived glucose state evaluation, assign a trust index to the user.

3 . The drug delivery system of claim 2 , wherein the programming code further causes the processor, when evaluating the perceived glucose state of the user indicated by the perceived state signal, to:

select a trust increment value based on how closely the perceived glucose state of the user matches the glucose measurement value obtained since the perceived state signal was received.

4 . The drug delivery system of claim 3 , wherein the programming code further causes the processor, when selecting the trust increment value, to:

compare the glucose measurement value to various glucose thresholds;

based on a result of the comparison, select the trust increment value from a plurality of trust increment values.

5 . The drug delivery system of claim 3 , wherein the selected trust increment value is an indicator of the user's reliability in perceiving their own glucose state.

6 . The drug delivery system of claim 3 , wherein the programming code further causes the processor, to:

calculate the trust index by increasing a trust level associated with the perceived glucose state based on the selected trust increment value.

7 . The drug delivery system of claim 6 , wherein the trust level represents a sum of trust increment values selected for a predetermined number of glucose measurement values obtained following receipt of the perceived state signal.

8 . The drug delivery system of claim 7 , wherein the programming code further causes the processor, when calculating the trust index, to:

calculate trust levels for a predetermined number of perceived state signals received from the user interface; and

determine an average trust level of the trust levels for the predetermined number of perceived state signals.

9 . The drug delivery system of claim 8 , wherein the predetermined number of perceived state signals received from the user interface correspond to previous perceived state signals that indicate the user's perceived glucose state is lower than a low glucose setpoint.

10 . The drug delivery system of claim 8 , wherein the predetermined number of perceived state signals received from the user interface correspond to previous perceived state signals that indicate the user's perceived glucose state is higher than a high glucose setpoint.

11 . The drug delivery system of claim 1 , wherein the user interface is operable to:

present a prompt requesting an input indicating the perceived glucose state of the user.

12 . A method for adjusting a drug delivery dosage based on a user's perceived glucose state, the method comprising:

receiving a signal from the user interface indicating a perceived glucose state of the user;

evaluating the perceived glucose state of the user indicated by the signal using a glucose measurement value corresponding in time to when the signal was received;

determining an adjustment to a drug delivery algorithm based on the perceived glucose state; and

utilizing the adjustment in a determination of a drug delivery dosage to be administered to a user.

13 . The method of claim 12 , further comprising:

based on a result of the perceived glucose state evaluation, assigning a trust index to the user.

14 . The method of claim 13 , further comprising:

selecting a trust increment value based on how closely the perceived glucose state of the user matches the glucose measurement value obtained since the signal was received.

15 . The method of claim 14 , further comprising:

comparing the glucose measurement value to various glucose thresholds;

based on a result of the comparison, selecting the trust increment value from a plurality of trust increment values.

16 . The method of claim 13 , wherein the selected trust increment value is an indicator of the user's reliability in perceiving their own glucose state.

17 . The method of claim 14 , further comprising:

calculating the trust index by increasing a trust level associated with the perceived glucose state based on the selected trust increment value.

18 . The method of claim 17 , wherein the trust level represents a sum of trust increment values selected for a predetermined number of glucose measurement values obtained following receipt of the signal from the user interface.

19 . The method of claim 18 , wherein calculating the trust index further comprises:

calculating trust levels for a predetermined number of signals received from the user interface; and

determining an average trust level of the trust levels for the predetermined number of signals.

20 . The method of claim 19 , wherein the predetermined number of signals received from the user interface correspond to signals that indicate the user's perceived glucose state is lower than a low glucose setpoint.