IP Library › Granted Patent US 12,268,745
Granted Patent B2
US 12,268,745 · App. 18/625,862 · Granted Apr 8, 2025

Material and method for treating internal cavities

Inventors: Asher Holzer (Raanana, IL); Dorit Daniel (Raanana, IL); Michael Mullerad (Tel Aviv, IL); Jaime De La Zerda (Haifa, IL); Uri Shpolansky (Pardes Hana, IL); Nadav Malchi (Pardes Hanna-Karkur, IL); Yosh Dollberg (Raanana, IL); Dor Tal (Hadera, IL); Yossi Yavin (Mikhmoret, IL)
Assignee: UroGen Pharma Ltd.
A61K47/34A61K9/0034A61K9/06A61K31/07A61K31/122A61K31/167A61K31/192A61K31/337A61K31/397A61K31/407A61K31/59A61K31/704A61K31/7068A61K38/4893A61K47/10A61K47/38
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Quick Facts
Patent No.
US 12,268,745
App. No.
18/625,862
Granted
Apr 8, 2025
Kind
B2
Abstract

A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.

Claims (15)

1. A method of treating renal pelvis cancer comprising:

(a) preparing a composition by incorporating an effective amount of mitomycin C and an accompanying excipient into a thermoreversible hydrogel, the accompanying excipient being mannitol; and

(b) administering the composition to a renal pelvis of a human in need of such treatment,

wherein the thermoreversible hydrogel comprises:

(i) 23% to 27% (w/w) poloxamer 407;

(ii) 0.15% to 0.2% (w/w) hydroxypropylmethylcellulose;

(iii) 0.5% to 1.8% (w/w) PEG-400; and

(iv) water.

2. The method of claim 1 , wherein the composition is administered via a urinary catheter.

3. The method of claim 2 , wherein the thermoreversible hydrogel comprises 27% (w/w) poloxamer 407.

4. The method of claim 2 , wherein the thermoreversible hydrogel comprises 0.2% (w/w) hydroxypropylmethylcellulose.

5. The method of claim 2 , wherein the thermoreversible hydrogel comprises 0.5% to 1.0% (w/w) PEG-400.

6. The method of claim 3 , wherein the thermoreversible hydrogel comprises 0.2% (w/w) hydroxypropylmethylcellulose.

7. The method of claim 6 , wherein the thermoreversible hydrogel comprises 0.5% to 1.0% (w/w) PEG-400.

8. The method of claim 7 , wherein the thermoreversible hydrogel comprises 1.0% (w/w) PEG-400.

Assignments (3)
SECOND AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Mar 2, 2026
From: UROGEN PHARMA LTD.
To: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
Reel/Frame 074994/0338 →
AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Aug 18, 2025
From: UROGEN PHARMA LTD.
To: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
Reel/Frame 072472/0233 →
AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Mar 6, 2025
From: UROGEN PHARMA LTD.
To: BIOPHARMA CREDIT PLC [COLLATERAL AGENT]
Reel/Frame 070434/0319 →
Continuity (8)
Continuation 18129497 · Mar 31, 2023
Division 17566882 · Dec 31, 2021
Continuation 16518511 · Jul 22, 2019
Continuation 14054731 · Oct 15, 2013
Continuation In Part 13553198 · Jul 19, 2012
Continuation In Part PCTIL2011000069 · Jan 20, 2011
Provisional Application 61296589 · Jan 20, 2010
Related Publication 20240299550A1 · Sep 12, 2024
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