IP Library Granted Patent US 12,211,124
Granted Patent B2
US 12,211,124 · App. 18/631,216 · Granted Jan 28, 2025

System and method for synthesizing low-dimensional image data from high-dimensional image data using an object grid enhancement

Inventors: Haili Chui (Fremont, CA); Xiaomin Liu (Sunnyvale, CA); Xiangwei Zhang (Fremont, CA)
Assignee: Hologic, Inc.
G06T11/005A61B6/502G06N20/00G06T7/0012G06T15/205G06T2207/10072G06T2207/10116G06T2207/30068
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Quick Facts
Patent No.
US 12,211,124
App. No.
18/631,216
Granted
Jan 28, 2025
Kind
B2
Abstract

A method for processing breast tissue image data includes processing image data of a patient's breast tissue to generate a high-dimensional grid depicting one or more high-dimensional objects in the patient's breast tissue; determining a probability or confidence of each of the one or more high-dimensional objects depicted in the high-dimensional grid; and modifying one or more aspects of at least one of the one or more high-dimensional objects based at least in part on its respective determined probability or confidence to thereby generate a lower-dimensional format version of the one or more high-dimensional objects. The method may further include displaying the lower-dimensional format version of the one or more high-dimensional objects in a synthesized image of the patient's breast tissue.

Claims (55)

1. A method for processing breast tissue image data, comprising:

obtaining a set of image slices that collectively depict a patient's breast tissue;

identifying a plurality of image patterns among slices of the set of image slices;

generating a high-dimensional object grid depicting the plurality of image patterns as two or more high-dimensional objects, each of the two or more high-dimensional objects having one or more features;

assigning a default weight to each of the two or more high-dimensional objects;

generating an interactive display of the high-dimensional object grid;

receiving, from the interactive display, a weight adjustment input associated with at least one of the two or more high-dimensional objects;

generating, based on the high-dimensional object grid and the weight adjustment input, a lower-dimensional format image of the two or more high-dimensional objects; and

modifying, based on the weight adjustment input, at least one feature of at least one of the two or more high-dimensional objects.

2. The method of claim 1 , wherein receiving the weight adjustment input associated with at least one of the two or more high-dimensional objects comprises:

receiving a selection of a first object of the two or more high-dimensional objects; and

associating, automatically, based on the selection of the first object, the weight adjustment input with the first object.

3. The method of claim 2 , wherein the weight adjustment input causes the first object to have a weight higher than the default weight.

4. The method of claim 2 , wherein modifying, based on the weight adjustment input, at least one feature of at least one or the two or more high-dimensional objects comprises:

emphasizing the first object over other objects of the two or more high-dimensional objects in the lower-dimensional format image.

5. The method of claim 2 , further comprising receiving an indication that the weight adjustment input causes the first object to have a weight lower than the default weight.

6. The method of claim 5 , wherein the indication is a characterization of the first object as a background object.

7. The method of claim 5 , wherein the indication is a characterization of the first object as an object that is not included in the lower-dimensional format image.

8. The method of claim 1 , further comprising displaying the lower-dimensional format image.

9. A system comprising:

a computer-readable memory storing executable instructions; and

one or more processors in communication with the computer-readable memory, wherein, when the one or more processors execute the executable instructions, the one or more processors perform:

obtaining a set of image slices that collectively depict a patient's breast tissue;

identifying a plurality of image patterns among slices of the set of image slices;

generating a high-dimensional object grid depicting the plurality of image patterns as two or more high-dimensional objects, each of the two or more high-dimensional objects having one or more features;

assigning a default weight to each of the two or more high-dimensional objects;

generating an interactive display of the high-dimensional object grid;

receiving, from the interactive display, a weight adjustment input associated with at least one of the two or more high-dimensional objects;

generating, based on the high-dimensional object grid and the weight adjustment input, a lower-dimensional format image of the two or more high-dimensional objects; and

modifying, based on the weight adjustment input, at least one feature of at least one of the two or more high-dimensional objects.

10. The system of claim 9 , wherein the one or more processors further perform receiving the weight adjustment input associated with at least one of the two or more high-dimensional objects comprising:

receiving a selection of a first object of the two or more high-dimensional objects; and

associating, automatically, based on the selection of the first object, the weight adjustment input with the first object.

11. The system of claim 10 , wherein the one or more processors further perform that the weight adjustment input causes the first object to have a weight higher than the default weight.

12. The system of claim 10 , wherein the one or more processors further perform modifying, based on the weight adjustment input, at least one feature of at least one or the two or more high-dimensional objects comprising:

emphasizing the first object over other objects of the two or more high-dimensional objects in the lower-dimensional format image.

13. The system of claim 10 , wherein the one or more processors further perform receiving an indication that the weight adjustment input causes the first object to have a weight lower than the default weight.

14. The system of claim 13 , wherein the one or more processors further perform that the indication is a characterization of the first object as a background object.

15. A non-transitory computer readable medium having stored thereon one or more sequences of instructions for causing one or more processor to perform:

obtaining a set of image slices that collectively depict a patient's breast tissue;

identifying a plurality of image patterns among slices of the set of image slices;

generating a high-dimensional object grid depicting the plurality of image patterns as two or more high-dimensional objects, each of the two or more high-dimensional objects having one or more features;

assigning a default weight to each of the two or more high-dimensional objects;

generating an interactive display of the high-dimensional object grid;

receiving, from the interactive display, a weight adjustment input associated with at least one of the two or more high-dimensional objects;

generating, based on the high-dimensional object grid and the weight adjustment input, a lower-dimensional format image of the two or more high-dimensional objects; and

modifying, based on the weight adjustment input, at least one feature of at least one of the two or more high-dimensional objects.

16. The non-transitory computer readable medium of claim 15 , wherein the one or more processors further perform receiving the weight adjustment input associated with at least one of the two or more high-dimensional objects comprising:

receiving a selection of a first object of the two or more high-dimensional objects; and

associating, automatically, based on the selection of the first object, the weight adjustment input with the first object.

17. The non-transitory computer readable medium of claim 16 , wherein the one or more processors further perform that the weight adjustment input causes the first object to have a weight higher than the default weight.

18. The non-transitory computer readable medium of claim 16 , wherein the one or more processors further perform modifying, based on the weight adjustment input, at least one feature of at least one or the two or more high-dimensional objects comprising:

emphasizing the first object over other objects of the two or more high-dimensional objects in the lower-dimensional format image.

19. The non-transitory computer readable medium of claim 16 , wherein the one or more processors further perform receiving an indication that the weight adjustment input causes the first object to have a weight lower than the default weight.

20. The non-transitory computer readable medium of claim 19 , wherein the one or more processors further perform that the indication is a characterization of the first object as a background object.

Assignments (4)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 069172/0436 Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC
Reel/Frame 075503/0086 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Oct 14, 2024
From: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 069172/0436 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2024
From: CHUI, HAILI; LIU, XIAOMIN; ZHANG, XIANGWEI
To: HOLOGIC, INC.
Reel/Frame 067093/0675 →
Continuity (4)
Continuation 17871129 · Jul 22, 2022
Continuation 16497766
Provisional Application 62479008 · Mar 30, 2017
Related Publication 20240338864A1 · Oct 10, 2024
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